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Literature summary for 3.4.24.16 extracted from
- Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin (2005), J. Antibiot., 58, 775-786.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | agaricoglycerides are devoid of activity in a large number of biochemical and cellular assays, emphasizing their selectivity towards neurolysin | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| agaricoglyceride A | main active principle of the crude extract of Agaricus macrosporus shows strong activity against neurolysin | Rattus norvegicus |  |
| agaricoglyceride B | agaricoglyceride C, agaricoglyceride D, known cometabolites agaricic ester show no activity against neurolysin up to 0.01 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats, strain HSdCpB: WU | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS + H2O | - |
Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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