Literature summary for 3.4.24.16 extracted from

Cotter, E.J.; von Offenberg Sweeney, N.; Coen, P.M.; Birney, Y.A.; Glucksman, M.J.; Cahill, P.A.; Cummins, P.M.
Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling (2004), Arterioscler. Thromb. Vasc. Biol., 24, 457-463.

Search for more literature for 3.4.24.16

Application

Application	Comment	Organism
medicine	plays an important role in endothelium-mediated vasoregulation	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
additional information	dominant-negative G protein mutants used to selectively disrupt Gialpha- and Gbetagamma-mediated signaling pathways attenuated strain-dependent increases for the enzyme	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
molecular inhibitors of Gbetagama-dimer function	strain-dependent increases in EP24.16 activity are substantially attenuated by betaARK.ct by 86.4%	Bos taurus
molecular inhibitors of Gialpha-subunit function	force-dependent increase in cellular EP24.16 activity is strongly attenuated by Gialpha1-G202T by 69.6% and Gialpha2-G203T by 101.7%, whereas Gialpha2-G202T has no significant effect	Bos taurus
NF023	attenuates the strain-dependent elevation of endopeptidase activity by 82.2%	Bos taurus
PTX	completely attenuates the cyclic strain-dependent increase in endopeptidase activity	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular endothelial cell	-	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
ep24.16	-	Bos taurus

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Release 2023.1 (January 2023)