3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

3.4.24.16

bradykinin

metallopeptidase

metalloendopeptidase

dynorphins

pro-ile

neuropeptidase

pro10-tyr11

neuromedin

hemopressins

arg8-arg9

non-at2

neurotensin-degrading

molecular biology

pharmacology

medicine

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

endopeptidase 24.16, endopeptidase 24.16B, endopeptidase 3.4.24.16, EP 24.16, ep24.16, EP24.16c, EP24.16m, MEP, Microsomal endopeptidase, mitochondrial peptidase, MOP, More, NEL, neurolisin, neurolysin, neurotensin endopeptidase, neurotensin-cleaving enzyme, Nln, oligopeptidase M, peptidase, neurotensin endo, peptidase, neurotensin endo-, SABP, soluble angiotensin II-binding protein, Soluble angiotensin-binding protein, thimet oligopeptidase II, thimet peptidase II

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.16 neurolysin

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Results	in table
3	Activating Compound
26	AA Sequence
5	Application
2	CAS Registry Number
21	Cloned(Commentary)
6	Crystallization (Commentary)
77	Disease/ Diagnostics
4	Expression
17	General Information
3	General Stability
2	IC50 Value
196	Inhibitors
11	Ki Value [mM]
167	KM Value [mM]
46	Localization
24	Metals/Ions
12	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
202	Organism
8	PDB ID
8	pH Optimum
1	pH Range
3	Posttranslational Modification
17	Protein Variants
15	Purification (Commentary)
1	Reaction
2	Reaction Type
63	Reference
130	Source Tissue
13	Specific Activity [micromol/min/mg]
1	Storage Stability
343	Substrates and Products (Substrate)
13	Subunits
56	Synonyms
7	Temperature Optimum [°C]
207	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.24.16 - neurolysin

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6 - 14

(7-methoxy-coumarin-4-yl)acetyl-RPKPVE-Nva-WRK(2,4-dinitrophenyl)-NH2

show

7.7 - 19

(7-methoxy-coumarin-4-yl)acetyl-RPKPYA-Nva-WMK(2,4-dinitrophenyl)-NH2

show

0.002 - 0.0022

(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Ile-Arg-Arg-Ala-Lys-dinitrophenyl

show

0.0043

(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Leu-Arg-Arg-Ala-Lys-dinitrophenyl

Rattus norvegicus

-

-

0.0014

(o-aminobenzoyl)-AFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00115

(o-aminobenzoyl)-AKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.0023

(o-aminobenzoyl)-DFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00064

(o-aminobenzoyl)-EFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0058

(o-aminobenzoyl)-ENKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00083

(o-aminobenzoyl)-FFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0023

(o-aminobenzoyl)-GASPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0684

(o-aminobenzoyl)-GDSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0318

(o-aminobenzoyl)-GESPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00087

(o-aminobenzoyl)-GFAPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0003

(o-aminobenzoyl)-GFDPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0031

(o-aminobenzoyl)-GFEPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFFPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00033

(o-aminobenzoyl)-GFHPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00018

(o-aminobenzoyl)-GFIPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00019

(o-aminobenzoyl)-GFLPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00045

(o-aminobenzoyl)-GFNPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0037

(o-aminobenzoyl)-GFPPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.002

(o-aminobenzoyl)-GFQPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00039

(o-aminobenzoyl)-GFRPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFSAFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0018

(o-aminobenzoyl)-GFSDFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.003

(o-aminobenzoyl)-GFSEFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0015

(o-aminobenzoyl)-GFSFFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0013

(o-aminobenzoyl)-GFSHFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00085

(o-aminobenzoyl)-GFSIFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0018

(o-aminobenzoyl)-GFSLFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0013

(o-aminobenzoyl)-GFSNFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00012

(o-aminobenzoyl)-GFSPARQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0032

(o-aminobenzoyl)-GFSPDRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00022

(o-aminobenzoyl)-GFSPERQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00095

(o-aminobenzoyl)-GFSPFAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00023

(o-aminobenzoyl)-GFSPFDQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFSPFEQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.002

(o-aminobenzoyl)-GFSPFFQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0024

(o-aminobenzoyl)-GFSPFHQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00042

(o-aminobenzoyl)-GFSPFIQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0056

(o-aminobenzoyl)-GFSPFLQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0033

(o-aminobenzoyl)-GFSPFNQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00055

(o-aminobenzoyl)-GFSPFPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0061

(o-aminobenzoyl)-GFSPFQQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFSPFRA-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00018

(o-aminobenzoyl)-GFSPFRE-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00022

(o-aminobenzoyl)-GFSPFRF-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00044

(o-aminobenzoyl)-GFSPFRI-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0014

(o-aminobenzoyl)-GFSPFRL-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00015

(o-aminobenzoyl)-GFSPFRN-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0017

(o-aminobenzoyl)-GFSPFRP-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00058

(o-aminobenzoyl)-GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00021

(o-aminobenzoyl)-GFSPFRR-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00065

(o-aminobenzoyl)-GFSPFRS-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFSPFSQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00021

(o-aminobenzoyl)-GFSPHRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00091

(o-aminobenzoyl)-GFSPIRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0024

(o-aminobenzoyl)-GFSPLRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0002

(o-aminobenzoyl)-GFSPNRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0011

(o-aminobenzoyl)-GFSPPRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0013

(o-aminobenzoyl)-GFSPQRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00003

(o-aminobenzoyl)-GFSPRRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00078

(o-aminobenzoyl)-GFSPSRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0024

(o-aminobenzoyl)-GFSQFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00058

(o-aminobenzoyl)-GFSRFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0111

(o-aminobenzoyl)-GFSSFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0016

(o-aminobenzoyl)-GFSXFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00047

(o-aminobenzoyl)-GGFLPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.0005

(o-aminobenzoyl)-GGFLRRAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0033

(o-aminobenzoyl)-GGFLRRDQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0019

(o-aminobenzoyl)-GGFLRREQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0007

(o-aminobenzoyl)-GGFLRRFQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0017

(o-aminobenzoyl)-GGFLRRHQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0018

(o-aminobenzoyl)-GGFLRRIQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0007

(o-aminobenzoyl)-GGFLRRLQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0015

(o-aminobenzoyl)-GGFLRRNQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0012

(o-aminobenzoyl)-GGFLRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0023

(o-aminobenzoyl)-GGFLRRRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0022

(o-aminobenzoyl)-GGFLRRV-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0021

(o-aminobenzoyl)-GGFLRRVQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0006

(o-aminobenzoyl)-GGFLRRYQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C

0.0025

(o-aminobenzoyl)-GHSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0047

(o-aminobenzoyl)-GISPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0059

(o-aminobenzoyl)-GLSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0075

(o-aminobenzoyl)-GNSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0063

(o-aminobenzoyl)-GPSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0068

(o-aminobenzoyl)-GQSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0013

(o-aminobenzoyl)-GRSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0058

(o-aminobenzoyl)-GSSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00033

(o-aminobenzoyl)-HFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0012

(o-aminobenzoyl)-IFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0033

(o-aminobenzoyl)-KPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.0017

(o-aminobenzoyl)-LFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00044

(o-aminobenzoyl)-LYENKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00103

(o-aminobenzoyl)-NAPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.0013

(o-aminobenzoyl)-NFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00138

(o-aminobenzoyl)-NKARRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00056

(o-aminobenzoyl)-NKPARPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00082

(o-aminobenzoyl)-NKPRAPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00025

(o-aminobenzoyl)-NKPRRAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00119

(o-aminobenzoyl)-NKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00033

(o-aminobenzoyl)-QFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00032

(o-aminobenzoyl)-RFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.00048

(o-aminobenzoyl)-SFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.0006 - 0.0031

2-aminobenzoyl-GFSPFRQ-(N-2,4-dinitrophenyl)ethylenediamine

show

0.0498

7-methoxycoumarin-3-carboxylyl-Pro-Leu-Gly-Pro-Lys-dinitrophenyl

show

0.0009 - 0.0078

Abz-GFSAFRQEDDnp

show

0.0024 - 0.0053

Abz-GFSEFRQEDDnp

show

0.0015 - 0.0101

Abz-GFSFFRQEDDnp

show

0.0018 - 0.0106

Abz-GFSHFRQEDDnp

show

0.0008 - 0.0048

Abz-GFSIFRQEDDnp

show

0.0018 - 0.0061

Abz-GFSLFRQEDDnp

show

0.0016 - 0.021

Abz-GFSQFRQEDDnp

show

0.0008 - 0.0083

Abz-GFSRFRQEDDnp

show

0.0056 - 0.0111

Abz-GFSSFRQEDDnp

show

0.0008 - 0.006

Abz-GFSWFRQEDDnp

show

0.0012 - 0.0096

Abz-GFSyFRQEDDnp

show

0.05

dinitrophenyl-Pro-Leu-Gly-Pro-Trp-D-Lys

Rattus norvegicus

-

-

0.002 - 0.00295

neurotensin

show

0.007

pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

-

-

0.085

Tyr-Gly-Gly-Phe-Leu-Arg

Rattus norvegicus

-

-

0.041

Tyr-Gly-Gly-Phe-Leu-Arg-Arg

Rattus norvegicus

-

-

0.007

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile

Rattus norvegicus

-

-

0.013

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg

Rattus norvegicus

-

-

additional information

additional information

Rattus norvegicus

-

Km-values for the reaction with angiotensin I analogs

-

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Release 2023.1 (January 2023)