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Literature summary for 3.4.24.16 extracted from

  • Barrett, A.J.; Brown, M.A.; Dando, P.M.; Knight, C.G.; McKie, N.; Rawlings, N.D.; Serizawa, A.
    Thimet oligopeptidase and oligopeptidase M or neurolysin (1995), Methods Enzymol., 248, 529-556.
    View publication on PubMed
Search for more literature for 3.4.24.16

Activating Compound

Activating Compound Comment Organism Structure
thiols activate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus
dynorphin A(1-13)
-
 Rattus norvegicus
EDTA
-
 Rattus norvegicus
N-(phenylethylphosphonyl)-Gly-Pro-L-norleucine
-
 Rattus norvegicus
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-4-aminobenzoate
-
 Rattus norvegicus
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-4-aminobenzoate
-
 Rattus norvegicus
N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Pro-Phe-4-aminobenzoate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0022
-
 (7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Ile-Arg-Arg-Ala-Lys-dinitrophenyl
-
 Rattus norvegicus
0.0043
-
 (7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Leu-Arg-Arg-Ala-Lys-dinitrophenyl
-
 Rattus norvegicus
0.0498
-
 7-methoxycoumarin-3-carboxylyl-Pro-Leu-Gly-Pro-Lys-dinitrophenyl abvove Rattus norvegicus
0.05
-
 dinitrophenyl-Pro-Leu-Gly-Pro-Trp-D-Lys
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Ile-Arg-Arg-Ala-Lys-dinitrophenyl + H2O i.e. QF37, cleavage site: Arg6-Ala7 Rattus norvegicus (7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Ile-Arg-Arg + Ala-Lys-dinitrophenyl
-
 ?
(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Leu-Arg-Arg-Ala-Lys-dinitrophenyl + H2O i.e. QF34, cleavage sites: Leu4-Arg5, Arg5-Arg6 Rattus norvegicus peptide fragments
-
 ?
7-methoxycoumarin-3-carboxylyl-Pro-Leu-Gly-Pro-Lys-dinitrophenyl + H2O
-
 Rattus norvegicus ?
-
 ?
dinitrophenyl-Pro-Leu-Gly-Pro-Trp-D-Lys + H2O
-
 Rattus norvegicus peptide fragments
-
 ?
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu + H2O
-
 Rattus norvegicus pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro + Tyr-Ile-Leu
-
 ?
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln + H2O i.e. dynorphin A(1-17), cleavage sites: Lys11-Leu12, Leu12-Lys13 Rattus norvegicus peptide fragments
-
 ?

Synonyms

Synonyms Comment Organism
thimet peptidase II
-
 Rattus norvegicus