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3.1.3.9: glucose-6-phosphatase

This is an abbreviated version!
For detailed information about glucose-6-phosphatase, go to the full flat file.

Word Map on EC 3.1.3.9

Reaction

D-glucose 6-phosphate
+
H2O
=
D-glucose
 +
phosphate

Synonyms

D-glucose-6-phosphate phosphorylase, G-6-Pase, G6Pase, G6Pase-alpha, G6Pase-beta, G6PC, G6PC-2, G6PC-3, G6Pc1, G6PC2, Glc-6-P phosphohydrolase, Glc-6-Pase-alpha, Glc-6-Pase-beta, glucose 6-phosphatase, glucose 6-phosphate phosphatase, glucose 6-phosphate phosphohydrolase, glucose-6-phosphatase, glucose-6-phosphatase catalytic subunit 2, glucose-6-phosphatase catalytic subunit-related protein, glucose-6-phosphatase catalytic unit 2, glucose-6-phosphatase-alpha, glucose-6-phosphatase-beta, IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein, islet-specific glucose-6-phosphatase-related protein, phosphatase, glucose 6-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.9 glucose-6-phosphatase

Cloned

Cloned on EC 3.1.3.9 - glucose-6-phosphatase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning into an andoviral vector of nontagged or FLAG-tagged beta-subunit, expression in COS-1 cells
-
cloning of two principal constituents: the catalytic subunit and D-glucose 6-phosphate translocase, expression studies in COS cells
-
DNA and amino acid sequence determination and analysis of the gene encoding the catalytic subunit, amino acid sequence alignment, expression of the catalytic subunit
enzyme catalytic subunit and D-glucose 6-phosphate transporter component
-
enzyme isoform of brain: G6PC3
expressed in COS-1 cells
expressed in Escherichia coli BL21(DE3)-Rosetta2 cells
-
expressed in HEK-293 cells and Hep-G2 cells
-
expressed in Hep-G2, HeLa, and CV1 cells
-
expressed in rat H4IIE hepatoma cells
expressed in rat hepatocytes, HepG-2 cells, and H4IIE cells
-
expression of FLAG-tagged wild-type and mutant enzymes in COS-1 cells, the FLAG-tag reduces the activity of the recombinant wild-type enzyme compared to the non-tagged wild-type enzyme
expression of FLAG-tagged wild-type enzyme and mutants Y209C and T16R in COS-1 cells, very low expression level of mutant enzymes
expression of the enzyme in H4IIE cells, determination of promoter activity and regulation, influences on enzyme expression by e.g. tunicamycin and thapsigargin, overview
-
the expression of enzyme is transactivated by the transcription factor FKHR, DYRK1 is a specific co activator of FKHR
-
the expression of hepatic enzyme catalytic subunit in pancreatic islets is studied
-
transient expression of the catalytic subunit in Hep-G2 cells
-