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3.1.3.9: glucose-6-phosphatase

This is an abbreviated version!
For detailed information about glucose-6-phosphatase, go to the full flat file.

Word Map on EC 3.1.3.9

Reaction

D-glucose 6-phosphate
+
H2O
=
D-glucose
 +
phosphate

Synonyms

D-glucose-6-phosphate phosphorylase, G-6-Pase, G6Pase, G6Pase-alpha, G6Pase-beta, G6PC, G6PC-2, G6PC-3, G6Pc1, G6PC2, Glc-6-P phosphohydrolase, Glc-6-Pase-alpha, Glc-6-Pase-beta, glucose 6-phosphatase, glucose 6-phosphate phosphatase, glucose 6-phosphate phosphohydrolase, glucose-6-phosphatase, glucose-6-phosphatase catalytic subunit 2, glucose-6-phosphatase catalytic subunit-related protein, glucose-6-phosphatase catalytic unit 2, glucose-6-phosphatase-alpha, glucose-6-phosphatase-beta, IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein, islet-specific glucose-6-phosphatase-related protein, phosphatase, glucose 6-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.9 glucose-6-phosphatase

Engineering

Engineering on EC 3.1.3.9 - glucose-6-phosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D38V
the mutation leads to reduced levels of G6PC protein
E110Q
the mutation retains 16% of wild type activity
F322L
mutant has similar stability to wild type enzyme
F327del/V338F/I341N/L345R
the mutation leads to reduced levels of G6PC protein
G122D
mutant has similar stability to wild type enzyme
G188D/G188S/G188R
the mutation leads to reduced levels of G6PC protein
G222R
the mutation retains 2.6% of wild type activity
G350X
the mutation retains 41.5% of wild type activity
H119A
-
mutation inactivates the phosphatase
H119L
the mutation completely abolishes enzymatic activity
H176A
H179A
-
mutation completely abolishes the enzyme activity
H197T
-
no significant change of enzyme activity
H252A
-
no significant change of enzyme activity
H307A
-
no significant change of enzyme activity
H353A
-
no significant change of enzyme activity
H353X
the mutation retains 60% of wild type activity
H52A
-
no significant change of enzyme activity
H9A
-
no significant change of enzyme activity
K355X
the mutation retains 65% of wild type activity
L349X
the mutation retains 5.3% of wild type activity
N264K/L265P/G266V/G270V/G270R
the mutation leads to reduced levels of G6PC protein
P257L
the mutation retains 6.1% of wild type activity
Q347X
the mutation completely inactivates the G6PC enzyme
Q351X
the mutation retains 43% of wild type activity
R170Q
R170X
the mutation completely inactivates the G6PC enzyme
R295C/S298P
the mutation leads to reduced levels of G6PC protein
R83H
the mutation completely abolishes enzymatic activity
T145A
the mutation does not affect the enzyme activity compared to the wild type
T145D
the mutation does not affect the enzyme activity compared to the wild type
T16A
site-directed mutagenesis, 74-78% reduced activity compared to the wild-type enzyme
V166A
the mutation leads to reduced levels of G6PC protein
W63R/G68R
the mutation leads to reduced levels of G6PC protein
Y209C
Y209C/L211P/G222R
the mutation leads to reduced levels of G6PC protein
additional information