Application | Comment | Organism |
---|---|---|
medicine | the enzyme catalytic unit is a therapeutic target for the treatment of type 2 diabetes, and the putative D-glucose 6-phosphate transporter component of the system has become a therapeutic target as well | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
enzyme catalytic subunit and D-glucose 6-phosphate transporter component | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | Homo sapiens | enzyme system is required in hepatic D-glucose phosphorylation | D-glucose + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
D-glucose 6-phosphate + H2O = D-glucose + phosphate | two proposed concepts of structure-function relationships for enzyme, According to the substrate transport-catalytic unit concept, enzyme is a multicomponent system consisting of a fairly non-specific catalytic unit with its active site located on the lumental side of endoplasmic reticulum, and at least three transmembrane-spanning translocases that confer specificity to this system by allowing selective substrates/products access to, or egress from, the sequestered catalytic unit. According to the combined conformational flexibility-substrate transport concept, enzyme is a multifunctional enzyme embedded within the endoplasic reticulum membrane that possess both catalytic and substrate/product transport activities. | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Homo sapiens | D-glucose + phosphate | - |
? | |
D-glucose 6-phosphate + H2O | enzyme system is required in hepatic D-glucose phosphorylation | Homo sapiens | D-glucose + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme is multicomponent system, a 36000 Da enzyme catalytic subunit and a 46000 Da D-glucose 6-phosphate transporter component | Homo sapiens |