3.1.3.9: glucose-6-phosphatase
This is an abbreviated version!
For detailed information about glucose-6-phosphatase, go to the full flat file.
Word Map on EC 3.1.3.9
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3.1.3.9
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glycogen
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gluconeogenesis
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phosphoenolpyruvate
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carboxykinase
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hepatocytes
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pepck
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gluconeogenic
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hyperglycemia
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glucokinase
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hexokinase
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triglyceride
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cholesterol
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succinate
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fructose
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wistar
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glucagon
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mellitus
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pancreatic
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streptozotocin
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high-fat
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antidiabetic
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cytochemical
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5'-nucleotidase
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hypoglycemic
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streptozotocin-induced
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fructose-1,6-bisphosphatase
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glycogenolysis
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metformin
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amp-activated
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transpeptidase
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periportal
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preneoplastic
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phosphofructokinase
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translocase
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lipogenesis
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hepatocarcinogenesis
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ccl4
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hepatomegaly
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antihyperglycemic
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triphosphatase
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gamma-glutamyl
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forkhead
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perivenous
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chrebp
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medicine
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fbpase
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glycogenesis
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diethylnitrosamine
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hyperuricemia
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1,6-bisphosphatase
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cytochemistry
- 3.1.3.9
- glycogen
-
gluconeogenesis
- phosphoenolpyruvate
-
carboxykinase
- hepatocytes
- pepck
-
gluconeogenic
- hyperglycemia
- glucokinase
- hexokinase
- triglyceride
- cholesterol
- succinate
- fructose
- wistar
- glucagon
- mellitus
- pancreatic
- streptozotocin
-
high-fat
-
antidiabetic
-
cytochemical
- 5'-nucleotidase
-
hypoglycemic
-
streptozotocin-induced
- fructose-1,6-bisphosphatase
-
glycogenolysis
- metformin
-
amp-activated
- transpeptidase
-
periportal
-
preneoplastic
-
phosphofructokinase
- translocase
-
lipogenesis
-
hepatocarcinogenesis
- ccl4
- hepatomegaly
-
antihyperglycemic
- triphosphatase
-
gamma-glutamyl
-
forkhead
-
perivenous
-
chrebp
- medicine
- fbpase
-
glycogenesis
- diethylnitrosamine
-
hyperuricemia
-
1,6-bisphosphatase
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cytochemistry
Reaction
Synonyms
D-glucose-6-phosphate phosphorylase, G-6-Pase, G6Pase, G6Pase-alpha, G6Pase-beta, G6PC, G6PC-2, G6PC-3, G6Pc1, G6PC2, Glc-6-P phosphohydrolase, Glc-6-Pase-alpha, Glc-6-Pase-beta, glucose 6-phosphatase, glucose 6-phosphate phosphatase, glucose 6-phosphate phosphohydrolase, glucose-6-phosphatase, glucose-6-phosphatase catalytic subunit 2, glucose-6-phosphatase catalytic subunit-related protein, glucose-6-phosphatase catalytic unit 2, glucose-6-phosphatase-alpha, glucose-6-phosphatase-beta, IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein, islet-specific glucose-6-phosphatase-related protein, phosphatase, glucose 6-
ECTree
3.1.3.9 glucose-6-phosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.3.9 - glucose-6-phosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-2-fluoro-D-glucose 6-phosphate + H2O
2-deoxy-2-fluoro-D-glucose + phosphate
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18F-labeled model substrate
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ir
2-deoxy-2-fluoro-D-glucose-6-phosphate + H2O
2-deoxy-2-fluoro-D-glucose + phosphate
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-
-
-
?
beta-glycerophosphate + H2O
glycerol + phosphate
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1.2% of the activity with D-glucose 6-phosphate
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-
?
p-nitrophenylphosphate + H2O
p-nitrophenol + phosphate
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1.4% of the activity with D-glucose 6-phosphate
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-
?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
a better substrate in disrupted vesicles at pH 5.5 and pH 6.5
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?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
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only in disrupted vesicles
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme catalytic subunit expression is regulated independently from the glucose-6-phosphate transporter expression by metabolites, overview
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme is the key enzyme of the gluconeogenesis pathway, and is positively regulated by a extracellular multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively, while the glucokinase activity is inhibited by CF, regulation overview
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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-
-
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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enzyme system is required in hepatic D-glucose phosphorylation
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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key enzyme in D-glucose homeostasis
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme plays a important role of providing D-glucose during starvation
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
G6Pase facilitates microsomal D-glucose 6-phosphate uptake by D-glucose 6-phosphate transporter
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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key enzyme in glucose metabolism
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-
ir
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme is required for the final steps of glycogenolysis and gluconeogenesis
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the brain functional glucose-6-phosphatase complex is capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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-
-
-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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best substrate in disrupted and not disrupted vesicles at pH 5.5 and pH 6.5
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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enzyme is one of the rate-limiting enzymes of hepatic glucogenesis
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme catalyses the terminal reaction of gluconegenesis and glycogenolysis and plays a major role in the contol of blood glucose levels
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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the enzyme is required for the final steps of glycogenolysis and gluconeogenesis
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
dietary regulation of the enzyme in the liver glucose metabolism, overview
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-
?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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enzyme catalyses the final step in both glycogenolysis and glyconeogenesis
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?
diphosphate + H2O
2 phosphate
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23% of the activity with D-glucose 6-phosphate
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-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
best substrate in disrupted and not disrupted vesicles at pH 5.5 and pH 6.5
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?
additional information
?
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the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
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-
?
additional information
?
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activities for EC 3.1.3.9, EC 3.6.1.1, and pyrophosphate-glucose phosphotransferase are due to a single enzyme
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-
?
additional information
?
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cells of Dictyostelium discoideum form groups of about 20000 cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor. It appears that part of the counting factor signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size
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-
?
additional information
?
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the enzyme is involved in the mobilization of glucose from liver cells
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-
?
additional information
?
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enzyme deficiency causes glycogen storage disease type Ia, GSD-Ia, overview
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-
?
additional information
?
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enzyme deficiency causes glycogen storage disease type Ia, GSD-Ia, overview
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-
?
additional information
?
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glucose-6-phosphatase mutations affect protein stability and cause glycogen storgae disease type Ia, GSD-Ia, determined in Argentina, overview
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-
?
additional information
?
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glucose-6-phosphatase mutations affect protein stability and cause glycogen storgae disease type Ia, GSD-Ia, determined in Argentina, overview
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-
?
additional information
?
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reduced enzyme activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma, overview
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-
?
additional information
?
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-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
-
-
?
additional information
?
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-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
-
-
?
additional information
?
-
-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
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-
?
additional information
?
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the biosynthetic activity of the enzyme may act in concert with glycogen synthase during amino-acid-induced glycogenesis from glucose. Amino acids may play a role in increasing biosynthetic activity of the enzyme
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-
?
additional information
?
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the enzyme probably plays a key role in the down-regulation of the calcium signal required for glycogen mobilization
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-
?
additional information
?
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-
the role of the enzyme in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymatic basis for a substrate cycle betwen glucose and glucose 6-phosphate in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation
-
-
?
additional information
?
-
-
the main regulatory function of the enzyme is to buffer the glucose 6-phosphate concentration. Hyperglycemia stimulates glucose-6-phosphatase gene transcription
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-
?
additional information
?
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the activity of glucose-6-phosphate synthesis can serve as an adjunct to glucokinase in hepatic glucose phosphorylation and may function in liver-mediated, adjustable maintanance of blood glucose homeostasis
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-
?
additional information
?
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terminal reaction of the pathway of glycogenolysis and gluconeogenesis. Activity of the enzyme is influenced by changes of the phospholipids on the microsomal membrane
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-
?
additional information
?
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the multicomponent hepatic glucose 6-phosphatase system catalyzes the terminal step of the hepatic glucose production and plays a role in the regulation of blood glucose
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?
additional information
?
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endoplasmic stress may play a role in diabetes, and it results in increased enzyme activity in the liver, overview
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-
?
