3.1.3.9: glucose-6-phosphatase
This is an abbreviated version!
For detailed information about glucose-6-phosphatase, go to the full flat file.
Word Map on EC 3.1.3.9
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3.1.3.9
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glycogen
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gluconeogenesis
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phosphoenolpyruvate
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carboxykinase
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hepatocytes
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pepck
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gluconeogenic
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hyperglycemia
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glucokinase
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hexokinase
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triglyceride
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cholesterol
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succinate
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fructose
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wistar
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glucagon
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mellitus
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pancreatic
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streptozotocin
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high-fat
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antidiabetic
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cytochemical
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5'-nucleotidase
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hypoglycemic
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streptozotocin-induced
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fructose-1,6-bisphosphatase
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glycogenolysis
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metformin
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amp-activated
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transpeptidase
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periportal
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preneoplastic
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phosphofructokinase
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translocase
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lipogenesis
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hepatocarcinogenesis
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ccl4
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hepatomegaly
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antihyperglycemic
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triphosphatase
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gamma-glutamyl
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forkhead
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perivenous
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chrebp
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medicine
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fbpase
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glycogenesis
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diethylnitrosamine
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hyperuricemia
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1,6-bisphosphatase
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cytochemistry
- 3.1.3.9
- glycogen
-
gluconeogenesis
- phosphoenolpyruvate
-
carboxykinase
- hepatocytes
- pepck
-
gluconeogenic
- hyperglycemia
- glucokinase
- hexokinase
- triglyceride
- cholesterol
- succinate
- fructose
- wistar
- glucagon
- mellitus
- pancreatic
- streptozotocin
-
high-fat
-
antidiabetic
-
cytochemical
- 5'-nucleotidase
-
hypoglycemic
-
streptozotocin-induced
- fructose-1,6-bisphosphatase
-
glycogenolysis
- metformin
-
amp-activated
- transpeptidase
-
periportal
-
preneoplastic
-
phosphofructokinase
- translocase
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lipogenesis
-
hepatocarcinogenesis
- ccl4
- hepatomegaly
-
antihyperglycemic
- triphosphatase
-
gamma-glutamyl
-
forkhead
-
perivenous
-
chrebp
- medicine
- fbpase
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glycogenesis
- diethylnitrosamine
-
hyperuricemia
-
1,6-bisphosphatase
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cytochemistry
Reaction
Synonyms
D-glucose-6-phosphate phosphorylase, G-6-Pase, G6Pase, G6Pase-alpha, G6Pase-beta, G6PC, G6PC-2, G6PC-3, G6Pc1, G6PC2, Glc-6-P phosphohydrolase, Glc-6-Pase-alpha, Glc-6-Pase-beta, glucose 6-phosphatase, glucose 6-phosphate phosphatase, glucose 6-phosphate phosphohydrolase, glucose-6-phosphatase, glucose-6-phosphatase catalytic subunit 2, glucose-6-phosphatase catalytic subunit-related protein, glucose-6-phosphatase catalytic unit 2, glucose-6-phosphatase-alpha, glucose-6-phosphatase-beta, IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein, islet-specific glucose-6-phosphatase-related protein, phosphatase, glucose 6-
ECTree
3.1.3.9 glucose-6-phosphataseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.1.3.9 - glucose-6-phosphatase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
beta-naphthoflavone
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the activation in dependence on the age of rats is studied
calyculin A
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activation of enzyme in supernatant and in intact or disrupted microsomes
forskolin
forskolin treatment promotes a 70% stimulation of G6Pase activity. The increase in glucose-6-phosphate transporter activity is required for the stimulation of glucose-6-phosphatase activity by forskolin
glycocorticoids
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injection of glycocorticoids in vivo increases to a modestextent the activity of enzyme in the livers of control and adrenalectomized rats
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Histone 2A
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stimulates enzyme activity by permeabilizing the microsomal membrane
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microcystin-LR
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activation of enzyme in supernatant and in intact or disrupted microsomes
microcystin-RR
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activation of enzyme in supernatant and in intact or disrupted microsomes
okadaic acid
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activation of enzyme in supernatant and in intact or disrupted microsomes
D-glucose
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elevated concentration, D-glucose may play a direct role as a stimulator of enzyme expression
D-glucose
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induces the expression of G-6-Pase at transcriptional and posttranscriptional levels, strongly increases endogenous G-6-Pase mRNA levels in 832/13 cells and in rat pancreatic islets. Induced levels from islets are still markedly lower than in untreated primary hepatocytes
additional information
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selective stimulation of expression by glucagon in vivo and cAMP in situ, of recombinant enzyme catalytic subunit expressed in human Hep-G2 cells or native enzyme catalytic subunit in pancreatic-clamped or liver-clamped, euglycemic conscious dogs, overview
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additional information
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higher G6Pase activities are recorded in fish fed glucose diet than in fish fed glucose-free diet
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additional information
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the enzyme is positively regulated by a secreted multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively
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additional information
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in crude cytosols glucose-6-phosphatase activity has a positive correlation with counting factor accumulation. Molecules greater than 10 kDa from cells with low counting factor activity significantly increase activity of glucose-6-phosphatase in wild-type microsomes. In smlA- and wild-type cells, detergent treatment with Triton X-100 to allow direct access of D-glucose 6-phosphate to the catalytic subunit does not increase enzymatic activity. In low counting factor crude microsomes, detergent treatment increases glucose-6-phosphatase activity
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additional information
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secreted multipolypeptide complex called counting factor regulates one or more proteins greater than 10000 Da in crude cytosol that affect microsome-associated glucose-6-phosphatase activity
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additional information
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Foxo1 synergizes with HNF-4 in activating the G6Pase gene transcription
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additional information
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O-glycosylation of Forkhead Box Other-1 trancription factor increases its transcriptional activity towards the glucose 6-phosphatase gene
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additional information
Foxa2 and MafA but not Pdx-1 directly regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. Pdx-1, Foxa2, and MafA binding is required for maximal IGRP promoter activity.
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additional information
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Foxa2 and MafA but not Pdx-1 directly regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression. Pdx-1, Foxa2, and MafA binding is required for maximal IGRP promoter activity.
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additional information
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Foxo1 synergizes with HNF-4 in activating the G6Pase gene transcription
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additional information
peroxisome proliferator activated receptor gamma coactivator-1alpha stimulates mouse G6pc-luciferase fusion gene expression through hepatocyte nuclear factor-4alpha
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additional information
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peroxisome proliferator activated receptor gamma coactivator-1alpha stimulates mouse G6pc-luciferase fusion gene expression through hepatocyte nuclear factor-4alpha
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additional information
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endoplasmic stress, induced by treatment of hepatocytes with tunicamycin and thapsigargin, leads to induction of enzyme activity in hepatocytes, overview
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additional information
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distinct cis-regulatory promoter elements are involved in the glucose response of the rat G-6-Pase gene. Full-length (-4078/+64) promoter confers a moderate glucose response to a reporter construct in HL1C rat hepatoma cells, which is dependent on coexpression of glucokinase. The same construct provides a robust glucose response in 832/13 INS-1 rat insulinoma cells, which are not glucogenic
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additional information
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G6Pase activitiy and gene expression is not influenced by dietary carbohydrates
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additional information
G6Pase activitiy and gene expression is not influenced by dietary carbohydrates
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additional information
higher G6Pase activities are recorded in fish fed glucose diet than in fish fed glucose-free diet
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