3.1.3.9: glucose-6-phosphatase This is an abbreviated version! For detailed information about glucose-6-phosphatase, go to the full flat file .
Reaction
D-glucose 6-phosphate +
H2O =
D-glucose +
phosphate
Synonyms D-glucose-6-phosphate phosphorylase, G-6-Pase, G6Pase, G6Pase-alpha, G6Pase-beta, G6PC, G6PC-2, G6PC-3, G6Pc1, G6PC2, Glc-6-P phosphohydrolase, Glc-6-Pase-alpha, Glc-6-Pase-beta, glucose 6-phosphatase, glucose 6-phosphate phosphatase, glucose 6-phosphate phosphohydrolase, glucose-6-phosphatase, glucose-6-phosphatase catalytic subunit 2, glucose-6-phosphatase catalytic subunit-related protein, glucose-6-phosphatase catalytic unit 2, glucose-6-phosphatase-alpha, glucose-6-phosphatase-beta, IGRP, islet-specific glucose-6-phosphatase catalytic subunit-related protein, islet-specific glucose-6-phosphatase-related protein, phosphatase, glucose 6-
ECTree
Source Tissue
Source Tissue on EC 3.1.3.9 - glucose-6-phosphatase
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liver cell
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red portion and white portion
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adrenal corrtex
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Marmota sp.
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adrenal corrtex
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adrenal corrtex
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adrenal corrtex
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low enzyme activities
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primary
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Frog
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expression of G6PC3 isoform
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contains a functional glucose-6-phosphatase complex capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose
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equally distributed in all areas of the brain
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the enzyme is found in all parts of the brain in the membraneous subcellular fractions of neurons
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Pachnoda ephippiata
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Pachnoda ephippiata
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Phryganea sp.
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Sarcophaga barbata
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Vespa vulgaris
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expression of G6PC3 isoform
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primary
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perifused hepatocyte
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juvenile fish
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hepatitis virus-induced hepatocellular carcinoma
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cortex
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expression of G6PC1 and G6PC3 isoforms
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cortex
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cortex, both mRNA and activity of enzyme appear during the first days of extratrauterine life, reaching a maximum after 2-3 weeks
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microsome
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Frog
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expression of G6PC1 isoform
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enzyme activity in healthy and aged liver, activities in different liver regions
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the woodchuck model of hepatocellular carcinoma has significantly decreased levels of G6Pase compared to healthy woodchuck. Significant differences in G6Pase activity between hepatocellular carcinoma liver region and surrounding normal liver region in the same woodchuck model of hepatocellular carcinoma
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134923 , 134935 , 134941 , 134945 , 649623 , 649729 , 665603 , 696104 , 698836 , 710573 , 751577 brenda
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134923 , 134924 , 134926 , 134928 , 134931 , 134935 , 134938 , 134940 , 134941 , 134944 , 134945 , 134947 , 134948 , 134949 , 134951 , 134952 , 134954 , 134955 , 134956 , 649477 , 649740 , 650948 , 651331 , 653110 , 664764 , 679853 , 701323 , 708318 , 708538 , 710626 , 713961 brenda
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hepatocytes
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hepatoma cells, cell line MH1C1
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enzyme activities greatly increases in rat liver around birth, the activities appears to be less specific in extracts of fetal liver enzyme than of adult liver
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of arthritic and control rats in the fed and fast states
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microsome
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perifused hepatocyte
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heaptic enzyme activity and gene expression are neither influenced by dietary carbohydrates nor water temperature
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respiratory epithelium
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Frog
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pancreatic islets
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salamander
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pancreatic islets
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expression of G6PC3 isoform
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syncytiotrophoblasts
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expression of G6PC3 isoform
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low enzyme activities
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additional information
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Ax4 cell, HDB7YA cell (smlA- cell), HDB2B/4 cell (cells with low counting factor)
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additional information
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the enzyme is expressed in beta-cells of pancreatic islets and in intestinal musoca, most particulary in the starved and diabetic states
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additional information
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IGRP13-25 and IGRP226-238 are DR0301-restricted epitopes, whereas IGRP23-35 and IGRP247-259 are DR0401-restricted epitopes
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additional information
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the enzyme is expressed in beta-cells of pancreatic islets and in intestinal musoca, most particulary in the starved and diabetic states
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additional information
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expression of the enzyme and of glucose 6-phosphate transporter, overview, two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astrocytes, overview
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additional information
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the enzyme is expressed in beta-cells of pancreatic islets and in intestinal musoca, most particulary in the starved and diabetic states
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