3.1.1.32: phospholipase A1
This is an abbreviated version!
For detailed information about phospholipase A1, go to the full flat file.
Word Map on EC 3.1.1.32
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3.1.1.32
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phospholipid
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platelet
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phospholipases
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lysosomal
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lysophospholipase
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phosphatidylethanolamine
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venom
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lysophospholipids
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thrombocytopenia
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lysophosphatidylcholine
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lipases
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arachidonic
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alloimmune
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wasp
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alloantigens
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purpura
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platelet-specific
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hymenoptera
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deacylation
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lysophosphatidic
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gpiiia
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hornet
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hypotrichosis
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2-acyl
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vespula
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vespid
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posttransfusion
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component-resolved
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plasmalogens
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degumming
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alloantibody
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monoacylglycerol
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3.1.1.4
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phospholipidosis
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lysophosphatidylinositol
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woolly
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glanzmann
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thrombasthenia
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degradation
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synthesis
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medicine
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lysophosphatidylethanolamine
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pharmacology
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food industry
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nutrition
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analysis
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industry
- 3.1.1.32
- phospholipid
- platelet
- phospholipases
- lysosomal
- lysophospholipase
- phosphatidylethanolamine
- venom
- lysophospholipids
- thrombocytopenia
- lysophosphatidylcholine
- lipases
-
arachidonic
-
alloimmune
- wasp
-
alloantigens
- purpura
-
platelet-specific
- hymenoptera
-
deacylation
-
lysophosphatidic
-
gpiiia
- hornet
- hypotrichosis
-
2-acyl
- vespula
-
vespid
-
posttransfusion
-
component-resolved
- plasmalogens
-
degumming
-
alloantibody
- monoacylglycerol
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3.1.1.4
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phospholipidosis
- lysophosphatidylinositol
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woolly
-
glanzmann
- thrombasthenia
- degradation
- synthesis
- medicine
- lysophosphatidylethanolamine
- pharmacology
- food industry
- nutrition
- analysis
- industry
Reaction
Synonyms
Allergen Dol m 1.01, Allergen Dol m 1.02, AtLCAT3, BveA, DAD1, DDHD1, DDL1, endothelial lipase, H-Rev107, hepatic lipase, intracellular phospholipase A1, IPLA-1, lacrimal lipase, lipase H, LipH, LIPI, LPC, membrane-associated phosphatidic acid-selective phospholipase A1, More, mPA-PLA1, mPA-PLA1alpha, mPA-PLA1beta, OM PLA, OMPLA, outer membrane phospholipase A, PA-PLA1, PA-PLA1/DDHD1, pancreatic lipase-associated protein 2, pancreatic lipase-related protein 2, PAPLA1, phosphatidate 1-acylhydorolase, phosphatidic acid phospholipase A1, phosphatidic acid-preferring phospholipase A1, phosphatidic acid-preferring phospholipase A1/DDHD1, phosphatidic acid-selective phospholipase A, phosphatidic acid-specific phospholipase A1, Phosphatidylcholine 1-acylhydrolase, phospholipase A1, phospholipase A1 alpha, phospholipase A1/2, phospholipase A1beta, phospholipase A1gamma, phospholipase beta, Pla, PLA 1, PLA A1, PLA1, PLA1/2, PLA1A, PLA1gamma, PLA1S, Plase A1, PLRP2, PPL, Rab5-activated phospholipase A1, RP534 PLA, RP534 protein, Ves a 1, Ves v 1, vespapase, VesTS1, VipD, Yor022c
ECTree
3.1.1.32 phospholipase A1Advanced search results
results (
results (Activating Compound
Activating Compound on EC 3.1.1.32 - phospholipase A1
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1-propanol
Corticium centrifugum
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stimulates phospholipase A1 activity and inhibits lysophospholipase 1 activity
Rab22
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a guanine nucleotide binding protein, activates the VipD phospholipase A1, C-terminal binding
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Rab5
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a guanine nucleotide binding protein, activates the VipD phospholipase A1, C-terminal binding, enzyme activity with constitutively active conformation of Rab5, Rab5a Q79L or Rab5c Q80L, is compared with the constitutively inactive forms Rab5a S34N or Rab5c S35N. Active Rab5 stimulates phospholipase activity only in full-length VipD, not in the truncated enzyme comprising residues 2-621
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tumor necrosis factor-alpha
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stimulates secretion of endothelial lipase, the stimulation can be inhibited by adiponectin
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dithiothreitol
required for full activity. Addition of 2 mM increases PLA1/2 activity 167fold
sodium deoxycholate
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phospholipase A1 activity is greatly stimulated, lysophospholipase activity is inhibited
Triton X-100
Corticium centrifugum
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stimulates phospholipase A1 activity and inhibits lysophospholipase 1 activity
additional information
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the enzyme is activated by the binding of isoprenaline to beta2-adrenergic receptors
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additional information
purified H-Rev107 exhibits an 88fold higher PLA1/2 activity than the cytosolic fraction
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additional information
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addition of bovine liver superoxide dismutase 1, SOD1, resultes in an increased rate of RP534-catalyzed phospholipid hydrolysis, mechanism, overview
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additional information
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NO2 specifically reacts with the plasma membrane component of pulmonary artery endothelial cells, causing specific activation of the enzyme
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additional information
TbPLA1 does not require metal cofactors for activity, but it does require interfacial activation prior to catalysis, activation by Triton X-100/glycerophosphatidylcholine mixed micelle surfaces is not specific and does not require the preformation of a specific enzyme-substrate complex to achieve surface binding, activation kinetics and mechanism, overview
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additional information
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TbPLA1 does not require metal cofactors for activity, but it does require interfacial activation prior to catalysis, activation by Triton X-100/glycerophosphatidylcholine mixed micelle surfaces is not specific and does not require the preformation of a specific enzyme-substrate complex to achieve surface binding, activation kinetics and mechanism, overview
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