3.1.1.32: phospholipase A1

This is an abbreviated version!
For detailed information about phospholipase A1, go to the full flat file.

Reaction

Synonyms

Allergen Dol m 1.01, Allergen Dol m 1.02, AtLCAT3, BveA, DAD1, DDHD1, DDL1, endothelial lipase, H-Rev107, hepatic lipase, intracellular phospholipase A1, IPLA-1, lacrimal lipase, lipase H, LipH, LIPI, LPC, membrane-associated phosphatidic acid-selective phospholipase A1, More, mPA-PLA1, mPA-PLA1alpha, mPA-PLA1beta, OM PLA, OMPLA, outer membrane phospholipase A, PA-PLA1, PA-PLA1/DDHD1, pancreatic lipase-associated protein 2, pancreatic lipase-related protein 2, PAPLA1, phosphatidate 1-acylhydorolase, phosphatidic acid phospholipase A1, phosphatidic acid-preferring phospholipase A1, phosphatidic acid-preferring phospholipase A1/DDHD1, phosphatidic acid-selective phospholipase A, phosphatidic acid-specific phospholipase A1, Phosphatidylcholine 1-acylhydrolase, phospholipase A1, phospholipase A1 alpha, phospholipase A1/2, phospholipase A1beta, phospholipase A1gamma, phospholipase beta, Pla, PLA 1, PLA A1, PLA1, PLA1/2, PLA1A, PLA1gamma, PLA1S, Plase A1, PLRP2, PPL, Rab5-activated phospholipase A1, RP534 PLA, RP534 protein, Ves a 1, Ves v 1, vespapase, VesTS1, VipD, Yor022c

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.1 Carboxylic-ester hydrolases

                3.1.1.32 phospholipase A1

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Results	in table
24	Activating Compound
10146	AA Sequence
20	Application
1	CAS Registry Number
40	Cloned(Commentary)
6	Crystallization (Commentary)
441	Disease/ Diagnostics
3	Expression
32	General Information
4	General Stability
1	IC50 Value
101	Inhibitors
3	kcat/KM [mM/s]
14	KM Value [mM]
81	Localization
35	Metals/Ions
40	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
7	Organic Solvent Stability
314	Organism
7	Pathway
17	PDB ID
41	pH Optimum
12	pH Range
5	pH Stability
6	pI Value
5	Posttranslational Modification
60	Protein Variants
51	Purification (Commentary)
8	Reaction
1	Reaction Type
141	Reference
161	Source Tissue
34	Specific Activity [micromol/min/mg]
6	Storage Stability
264	Substrates and Products (Substrate)
34	Subunits
155	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
8	Temperature Range [°C]
16	Temperature Stability [°C]
5	Turnover Number [1/s]

pH Range

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pH Range on EC 3.1.1.32 - phospholipase A1

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2.6 - 5.2

Rattus norvegicus

-

pH 2.6: 83% of maximal activity, pH 4.5: 50% of maximal activity, pH 5.2: 10% of maximal activity

94307

2.7 - 4.8

Rattus norvegicus

-

pH 2.7: 40-60% of maximal activity, pH 4.8: 20-40% of maximal activity

94312

3 - 5

Rattus norvegicus

-

50% of maximal activity at pH 3.0 and at pH 5.0, lysosomal enzyme

94315

3 - 7

Trypanosoma cruzi

-

approx. 50% of maximal activity at pH 3.0, approx. 20% of maximal activity at pH 6.0

649705

3.5 - 4.5

Mus musculus

-

pH 3.5: about 30% of maximal activity, pH 4.5: about 25% of maximal activity

94310

4 - 11

Streptomyces albidoflavus

K0J3J2

activity range, profile overview

729743

5 - 10

Giardia intestinalis

-

activity range

681568

5.2 - 8.4

Escherichia coli

-

pH 5.2: 10% of maximal activity, pH 6.5: about 50% of maximal activity, pH 8.4: optimum

94324

6 - 8

Katsuwonus pelamis

-

about 25% of maximal activity at pH 6.0 and at pH 8.0

94341

6.2 - 9.5

Sus scrofa

-

approx. 6% of maximal activity at pH 6.2, approx. 23% of maximal activity at pH 9.5

650395

7.8 - 9.3

Bos taurus

-

pH 7.8: about 55% of maximal activity, pH 9.3: 90% of maximal activity

94338

8 - 10

Cavia porcellus

-

pH 8.0: about 50% of maximal activity, pH 10.0: about 45% of maximal activity

94325