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Disease on EC 3.1.1.32 - phospholipase A1

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
The stress response and the lung.
Adenocarcinoma of Lung
Lipase member H frequently overexpressed in human esophageal adenocarcinomas.
Alopecia
Novel small-insertion mutation in the LIPH gene in a patient with autosomal recessive woolly hair/hypotrichosis.
Amyotrophic Lateral Sclerosis
A Novel Missense Mutation of the DDHD1 Gene Associated with Juvenile Amyotrophic Lateral Sclerosis.
Anaphylaxis
Component-resolved diagnosis in anaphylaxis.
Arteriosclerosis
Hydrolysis of plasmalogen by phospholipase A1 from Streptomyces albidoflavus for early detection of dementia and arteriosclerosis
Hydrolysis of plasmalogen by phospholipase A1 from Streptomyces albidoflavus for early detection of dementia and arteriosclerosis.
Arthritis, Rheumatoid
Combination therapy with methotrexate and chloroquine in rheumatoid arthritis. A multicenter randomized placebo-controlled trial.
Atherosclerosis
No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction.
Autoimmune Diseases
Current Knowledge on the Biology of Lysophosphatidylserine as an Emerging Bioactive Lipid.
Bacterial Infections
The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri.
Bernard-Soulier Syndrome
Molecular defect in platelets from patients with bernard-soulier syndrome.
Carcinogenesis
Identification of LIPH as an unfavorable biomarkers correlated with immune suppression or evasion in pancreatic cancer based on RNA-seq.
Carcinoma
Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box.
Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
Murine H-rev107 gene encoding a class II tumor suppressor: gene organization and identification of an Sp1/Sp3-binding GC-box required for its transcription.
Carcinoma, Hepatocellular
Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors.
Phospholipase A in the plasma membranes in ascites hepatomas and of normal livers in rat.
Properties of microsomal phospholipases in rat liver and hepatoma.
The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids.
Carcinoma, Squamous Cell
Lipase member H frequently overexpressed in human esophageal adenocarcinomas.
Chagas Disease
Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease.
Colonic Neoplasms
A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants.
The phospholipase DDHD1 as a new target in colorectal cancer therapy.
Colorectal Neoplasms
The phospholipase DDHD1 as a new target in colorectal cancer therapy.
Cone-Rod Dystrophies
Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids.
Coronary Artery Disease
No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction.
Coronary Disease
[Thrombocyte lysosomal hydrolase activity in patients with ischemic heart disease, hyperlipidemia and obesity against a background of different diets]
Dementia
Hydrolysis of plasmalogen by phospholipase A1 from Streptomyces albidoflavus for early detection of dementia and arteriosclerosis
Hydrolysis of plasmalogen by phospholipase A1 from Streptomyces albidoflavus for early detection of dementia and arteriosclerosis.
Demyelinating Diseases
On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis.
Distemper
Plasmalogenase and phospholipase A1, A2, and L1 activities in white matter in canine distemper virus-associated demyelinating encephalomyelitis.
Encephalomyelitis
Plasmalogenase and phospholipase A1, A2, and L1 activities in white matter in canine distemper virus-associated demyelinating encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Phospholipid metabolism in experimental allergic encephalomyelitis: activity of brain phospholipase A1 towards specifically labelled glycerophospholipids.
Fatty Liver
Metabolic basis of diethylaminoethoxyhexestrol-induced phospholipid fatty liver.
Food Hypersensitivity
Component-resolved diagnosis in anaphylaxis.
Gallstones
Pathogenesis of hepatolithiasis based on the analysis of components of intrahepatic stones.
Phospholipase activity in human bile.
Granuloma
Identification and characterization of a phospholipase A1 activity type three secreted protein, PP_ExoU from Pseudomonas plecoglossicida NB2011, the causative agent of visceral granulomas disease in large yellow croaker (Larimichthys crocea).
Graves Disease
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Hepatitis C
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Hyperlipidemias
[Thrombocyte lysosomal hydrolase activity in patients with ischemic heart disease, hyperlipidemia and obesity against a background of different diets]
Hypersensitivity
A Role of Newly Found Auxiliary Site in Phospholipase A1 from Thai Banded Tiger Wasp (Vespa affinis) in Its Enzymatic Enhancement: In Silico Homology Modeling and Molecular Dynamics Insights.
Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Component-resolved diagnosis in anaphylaxis.
Diagnostic precision of component-resolved vs. extract-based in vitro diagnosis of hymenoptera venom allergy: effects on clinical management.
IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy.
Individual hymenoptera venom compounds induce upregulation of the basophil activation marker ectonucleotide pyrophosphatase/phosphodiesterase 3 (CD203c) in sensitized patients.
Prevalence of Pol d 1 Sensitization in Polistes dominula Allergy and Its Diagnostic Role in Vespid Double-Positivity.
Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity.
Hypertriglyceridemia
Effect of oxandrolone treatment on the activity of lipoprotein lipase, hepatic lipase and phospholipase A1 of human postheparin plasma.
Hypotrichosis
A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis.
A novel mutation in the Lipase H gene underlies autosomal recessive hypotrichosis and woolly hair.
Frameshift Sequence Variants in the Human Lipase-H Gene Causing Hypotrichosis.
In Vitro Analysis of LIPH Mutations Causing Hypotrichosis Simplex: Evidence Confirming the Role of Lipase H and Lysophosphatidic Acid in Hair Growth.
Loss-of-function variants in C3ORF52 result in localized autosomal recessive hypotrichosis.
Mutations in lipase H cause autosomal recessive hypotrichosis simplex with woolly hair.
Mutations in lipase H gene underlie autosomal recessive hypotrichosis in five Pakistani families.
Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis.
Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2).
The curly coat phenotype of the Ural Rex feline breed is associated with a mutation in the lipase H gene.
Infections
Accumulation of phospholipase A1 in tissue fluid of rabbits infected with Trypanosoma brucei.
Enhancement of phospholipase activity during poliovirus infection.
Phosphatidylserine-Specific Phospholipase A1 Involved in Hepatitis C Virus Assembly through NS2 Complex Formation.
Latex Hypersensitivity
Component-resolved diagnosis in anaphylaxis.
Lipidoses
Acid phospholipase A1 in liver--a brief survey.
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Liver Neoplasms, Experimental
Properties of microsomal phospholipases in rat liver and hepatoma.
Lupus Erythematosus, Systemic
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Lymphoma
Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box.
Silencing of the mouse H-rev107 gene encoding a class II tumor suppressor by CpG methylation.
Mastocytosis
Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Measles
Acid phospholipase A1 and A2 in the cells, and subcellular redistribution of their activities in the cells infected with measles virus.
Release of lysosomal phospholipase A1 and A2 into cytosol and rapid turnover of newly-formed lysophosphatidylcholine in FL cells during fusion-from-within induced by measles virus.
Medulloblastoma
A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.
Melanoma
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
Mucolipidoses
Phospholipids accumulation in mucolipidosis IV cultured fibroblasts.
Muscle Spasticity
Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.
Neoplasm Metastasis
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
Neoplasms
(1)H, (13)C, and (15)N resonance assignments of the N-terminal domain of human TIG3.
1H, 13C and 15N resonance assignments of human H-REV107 N-terminal domain.
A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants.
A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.
Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.
Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes.
Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer.
Growth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumors.
H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells.
Identification of LIPH as an unfavorable biomarkers correlated with immune suppression or evasion in pancreatic cancer based on RNA-seq.
Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box.
Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen.
Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
Murine H-rev107 gene encoding a class II tumor suppressor: gene organization and identification of an Sp1/Sp3-binding GC-box required for its transcription.
Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.
Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway.
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107.
Silencing of the mouse H-rev107 gene encoding a class II tumor suppressor by CpG methylation.
Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain.
Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
The phospholipase DDHD1 as a new target in colorectal cancer therapy.
The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type.
Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12.
Nervous System Diseases
The phospholipase DDHD1 as a new target in colorectal cancer therapy.
Neuroblastoma
A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.
Obesity
[Thrombocyte lysosomal hydrolase activity in patients with ischemic heart disease, hyperlipidemia and obesity against a background of different diets]
Ovarian Neoplasms
Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.
Pancreatic Neoplasms
A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants.
Paraparesis, Spastic
Impairment of brain and muscle energy metabolism detected by magnetic resonance spectroscopy in hereditary spastic paraparesis type 28 patients with DDHD1 mutations.
Paraplegia
A novel frameshift mutation of DDHD1 in a Japanese patient with autosomal recessive spastic paraplegia.
Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia.
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
phospholipase a1 deficiency
Phospholipases and the molecular basis for the formation of ceroid in Batten disease.
Purpura
Autoreactive platelet antibody in post transfusion purpura.
Nomifensine-induced immune hemolytic anemia and posttransfusion purpura in the same patient.
Purpura, Thrombocytopenic
Neonatal alloimmune thrombocytopenic purpura and congenital porencephaly in two siblings associated with a "new" maternal antiplatelet antibody.
The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
Retinal Degeneration
Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis.
Retinal Dystrophies
Mutations in DDHD1, encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation.
Sarcoma, Ewing
Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells.
Short Rib-Polydactyly Syndrome
Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids.
Spastic Paraplegia, Hereditary
Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids.
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis.
Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast.
Mitochondrial dysfunction in hereditary spastic paraparesis with mutations in DDHD1/SPG28.
Mutations in DDHD1, encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation.
Phosphorylation of human phospholipase A1 DDHD1 at newly identified phosphosites affects its subcellular localization.
Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.
Starvation
Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts.
Subacute Sclerosing Panencephalitis
On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis.
Testicular Neoplasms
H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells.
Thrombasthenia
Autoreactive platelet antibody in post transfusion purpura.
Deletion of the platelet-specific alloantigen PlA1 from platelets in Glanzmann's thrombasthenia.
Inheritance of the human platelet alloantigen, PlA1, in type I Glanzmann's thrombasthenia.
[Glanzmann thrombasthenia, PLA1 antigen and anti-Glanzmann antibody]
Thrombocytopenia
Alloimmune conditions and pregnancy.
Anti-Bak(a) neonatal alloimmune thrombocytopenia: possible prevention by intravenous immunoglobulin.
Elevated platelet-associated IgG in PlA1-negative mothers following sensitization to the PlA1 antigen during pregnancy.
Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2.
High-dose intravenous gammaglobulin (IVG) in neonatal immune thrombocytopenia.
Importance of platelet serologic testing for defining the cause of neonatal thrombocytopenia.
Improved assay for detection of platelet-specific PlA1 antibodies in neonatal alloimmune thrombocytopenia.
Intravenous gammaglobulin therapy for neonatal alloimmune thrombocytopenia.
Rapid screening of platelet donors for PlA1 (HPA-1a) alloantigen using a solid-phase microplate immunoassay.
Refractory thrombocytopenia due to anti-PLA1 antibodies following autologous peripheral blood stem cell transplantation: case report and review of literature.
[Alloimmune thrombocytopenia in the newborn infant caused by maternal PlA1 antibodies]
[Immune cytopenias in newborns]
[Post-transfusion thrombopenia treated with gammaglobulins]
[Pregnancy monitoring and labor planning in PLA1-induced neonatal alloimmunothrombocytopenia]
[Preparation of maternal platelets collected by separator for use in fetal transfusion in a case of alloimmunization by anti-PLA1]
Thrombocytopenia, Neonatal Alloimmune
Anti-Bak(a) neonatal alloimmune thrombocytopenia: possible prevention by intravenous immunoglobulin.
Elevated platelet-associated IgG in PlA1-negative mothers following sensitization to the PlA1 antigen during pregnancy.
Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2.
Improved assay for detection of platelet-specific PlA1 antibodies in neonatal alloimmune thrombocytopenia.
Intravenous gammaglobulin therapy for neonatal alloimmune thrombocytopenia.
Post-transfusion purpura and isoimmune neonatal thrombocytopenia in the same family.
Rapid screening of platelet donors for PlA1 (HPA-1a) alloantigen using a solid-phase microplate immunoassay.
[Neonatal alloimmune thrombocytopenia. Serological studies]
[Typing and detection of antibodies in the PLA system (platelet). Application to the study of neonatal thrombopenia by feto-maternal PLA allo-immunisation]
Thrombosis
Deep Vein Thrombosis After a Wild Bee Sting.
Transfusion Reaction
A dinucleotide deletion in exon 4 of the PlA2 allelic form of glycoprotein IIIa: implications for the correlation of serologic versus genotypic analysis of human platelet alloantigens.
Autoreactive platelet antibody in post transfusion purpura.
Captopril-enhanced binding of PlA1 (HPA-1a) antibodies in posttransfusion purpura.
Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2.
Nomifensine-induced immune hemolytic anemia and posttransfusion purpura in the same patient.
Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias.
Post-transfusion purpura and isoimmune neonatal thrombocytopenia in the same family.
Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen, Baka.
Posttransfusion purpura associated with an autoantibody directed against a previously undefined platelet antigen.
Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen.
Rapid screening of platelet donors for PlA1 (HPA-1a) alloantigen using a solid-phase microplate immunoassay.
Studies on the pathophysiology of posttransfusion purpura.
The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
[Post-transfusion thrombopenia treated with gammaglobulins]
[Posttransfusion purpura: identification of a new platelet antigen Leka. A case]
Vascular Diseases
Revealing Interfacial Lipid Hydrolysis Catalyzed by Phospholipase A1 at Molecular Level via Sum Frequency Generation Vibrational Spectroscopy and Fluorescence Microscopy.
Whooping Cough
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin.