3.1.1.32: phospholipase A1
This is an abbreviated version!
For detailed information about phospholipase A1, go to the full flat file.
Word Map on EC 3.1.1.32
-
3.1.1.32
-
phospholipid
-
platelet
-
phospholipases
-
lysosomal
-
lysophospholipase
-
phosphatidylethanolamine
-
venom
-
lysophospholipids
-
thrombocytopenia
-
lysophosphatidylcholine
-
lipases
-
arachidonic
-
alloimmune
-
wasp
-
alloantigens
-
purpura
-
platelet-specific
-
hymenoptera
-
deacylation
-
lysophosphatidic
-
gpiiia
-
hornet
-
hypotrichosis
-
2-acyl
-
vespula
-
vespid
-
posttransfusion
-
component-resolved
-
plasmalogens
-
degumming
-
alloantibody
-
monoacylglycerol
-
3.1.1.4
-
phospholipidosis
-
lysophosphatidylinositol
-
woolly
-
glanzmann
-
thrombasthenia
-
degradation
-
synthesis
-
medicine
-
lysophosphatidylethanolamine
-
pharmacology
-
food industry
-
nutrition
-
analysis
-
industry
- 3.1.1.32
- phospholipid
- platelet
- phospholipases
- lysosomal
- lysophospholipase
- phosphatidylethanolamine
- venom
- lysophospholipids
- thrombocytopenia
- lysophosphatidylcholine
- lipases
-
arachidonic
-
alloimmune
- wasp
-
alloantigens
- purpura
-
platelet-specific
- hymenoptera
-
deacylation
-
lysophosphatidic
-
gpiiia
- hornet
- hypotrichosis
-
2-acyl
- vespula
-
vespid
-
posttransfusion
-
component-resolved
- plasmalogens
-
degumming
-
alloantibody
- monoacylglycerol
-
3.1.1.4
-
phospholipidosis
- lysophosphatidylinositol
-
woolly
-
glanzmann
- thrombasthenia
- degradation
- synthesis
- medicine
- lysophosphatidylethanolamine
- pharmacology
- food industry
- nutrition
- analysis
- industry
Reaction
Synonyms
Allergen Dol m 1.01, Allergen Dol m 1.02, AtLCAT3, BveA, DAD1, DDHD1, DDL1, endothelial lipase, H-Rev107, hepatic lipase, intracellular phospholipase A1, IPLA-1, lacrimal lipase, lipase H, LipH, LIPI, LPC, membrane-associated phosphatidic acid-selective phospholipase A1, More, mPA-PLA1, mPA-PLA1alpha, mPA-PLA1beta, OM PLA, OMPLA, outer membrane phospholipase A, PA-PLA1, PA-PLA1/DDHD1, pancreatic lipase-associated protein 2, pancreatic lipase-related protein 2, PAPLA1, phosphatidate 1-acylhydorolase, phosphatidic acid phospholipase A1, phosphatidic acid-preferring phospholipase A1, phosphatidic acid-preferring phospholipase A1/DDHD1, phosphatidic acid-selective phospholipase A, phosphatidic acid-specific phospholipase A1, Phosphatidylcholine 1-acylhydrolase, phospholipase A1, phospholipase A1 alpha, phospholipase A1/2, phospholipase A1beta, phospholipase A1gamma, phospholipase beta, Pla, PLA 1, PLA A1, PLA1, PLA1/2, PLA1A, PLA1gamma, PLA1S, Plase A1, PLRP2, PPL, Rab5-activated phospholipase A1, RP534 PLA, RP534 protein, Ves a 1, Ves v 1, vespapase, VesTS1, VipD, Yor022c
ECTree
3.1.1.32 phospholipase A1Advanced search results
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results (Substrates Products
Substrates Products on EC 3.1.1.32 - phospholipase A1
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-didocosahexaenoyl-phosphatidylcholine + H2O
2-docosahexaenoyl-lysophosphatidylcholine + docosahexaenoic acid
-
19% of activity with 1-oleoyl-2-palmitoyl-phosphatidylcholine
-
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
2-myristoyl-sn-glycero-3-phosphocholine + myristic acid
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphocholine + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphocholine + octadecenoate
-
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphoethanolamine + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphoethanolamine + octadecenoate
-
-
-
?
1,2-dioctadecenoylthio-sn-glycero-3-phosphoglycerol + H2O
1-thio-2-octadecenoylthio-sn-glycero-3-phosphoglycerol + octadecenoate
-
-
-
?
1,2-dioleoylphosphatidylcholine + H2O
oleic acid + 2-oleoylglycerophosphocholine
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
2-palmitoyl-sn-glycerophosphocholine + palmitate
substrate from Glycine max
-
-
?
1- palmitoyl-2-oleoyl-phosphatidylcholine + H2O
2-oleoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-acyl-2-oleoyl-sn-glycerophosphocholine + H2O
acyl-glycerophosphocholine + oleic acid
-
labeled at the sn-2 position with [14C]oleic acid
-
-
?
1-acyl-lysophosphtidic acid + H2O
glycerol-3-phosphate + a carboxylate
-
7% of activity with phosphatidic acid
-
?
1-acyl-sn-glycero-3-phosphocholine + H2O
fatty acid + glycero-3-phosphocholine
-
-
-
-
?
1-myristoyl 2-oleyl phosphatidylcholine + H2O
2-oleylglycerophosphocholine + myristoate
-
-
-
?
1-oleoyl-2-palmitoyl-phosphatidylcholine + H2O
2-palmitoyl-lysophosphatidylcholine + oleic acid
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
1-palmitoyl-2-docosahexaenoyl-phosphatidylcholine + H2O
2-docosahexaenoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-palmitoyl-2-linoleoyl phosphatidylcholine + H2O
?
-
the enzyme is responsible for about two-thirds of plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine disappearance
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidyl choline + H2O
2-linoleoyl-lysophosphatidyl choline + palmitic acid
-
-
?
1-palmitoyl-2-linoleoyl-phosphorylcholine + H2O
palmitic acid + 2-linoleoyl-1-lysophosphoryl choline
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-3-glycerophosphorylethanolamine + H2O
palmitic acid + 2-linoleoyl-sn-3-glycerophosphorylethanolamine
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
2-oleoyl-lysophosphatidylcholine + palmitic acid
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
1-palmitoyl-2-oleyl-phosphatidylcholine + H2O
2-oleyl-lysophosphatidylcholine + palmitate
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidylethanolamine + H2O
2-oleyl-lysophosphatidylethanolamine + palmitate
-
-
-
-
?
1-palmitoyl-2-palmitoylglycerophosphocholine + H2O
palmitic acid + 2-palmitoylglycerophosphocholine
-
-
-
-
?
1-palmitoyllysophosphatidylcholine + H2O
palmitic acid + lysophosphatidylcholine
-
weak activity
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol
1-stearoyl-2-arachidonyl-sn-glycero-3-phosphoinositol + H2O
2-arachidonylglycero-3-phosphoinositol + ?
-
-
no release of free arachidonate
?
2-acyl-sn-glycero-3-phosphocholine + H2O
fatty acid + glycerophosphocholine
-
-
-
-
?
2-hexadecanoylthio-ethane-1-phosphocholine + H2O
thio-ethane-1-phosphocholine + hexadecanoate
-
-
-
?
2-oleoylphosphatidylcholine + H2O
oleic acid + glycerophosphocholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylcholine + H2O
fatty acid + lysophosphatidylcholine
-
-
-
-
?
diacyl-sn-glycero-3-phosphorylethanolamine + H2O
fatty acid + lysophosphatidylethanolamine
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
hexadecanoylthioethane-1-phosphocholine + H2O
hexadecanoate + thioethane-1-phosphocholine
-
-
-
?
L-alpha-phosphatidyl-L-serine + H2O
2-acyl-1-glycerophosphoserine + a carboxylate
substrate from Glycine max
-
-
?
L-alpha-phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
PLA1 activity for egg yolk lecithin hydrolysis, substrate from egg yolk or Glycine max
-
-
?
L-alpha-phosphatidylinositol + H2O
2-acyl-sn-glycero-3-phosphoinositol + a carboxylate
-
-
-
?
monogalactosyldiacylglycerol + H2O
1-lyso-2-acyl-3-galactosyl-sn-glycerol + a fatty acid anion
-
-
-
?
phosphatidic acid + H2O
2-acylglycerol-3-phosphate + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acyllysophosphatidic acid + a carboxylate
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidylcholine + 2-acylglycerophosphocholine
2-acylglycerophosphocholine + phosphatidylcholine
-
regiospecific transacylation activity, PLA1 transfers a fatty acid at the sn-1 position of a donor phosphatidylcholine to the sn-1 position of an acceptor 2-acyl-lysophosphatidylcholine
-
?
phosphatidylcholine + H2O
1-acyl-2-oleoyl-sn-glycerophosphocholine + arachidonic acid
-
labeled at the sn-2 position with [14C]arachadonic acid
-
-
?
phosphatidylinositol + H2O
lysophosphatidylinositol + a carboxylate
-
1% of activity with phosphatidic acid, at 0.1% Triton X-100
-
?
phosphatidylserine + H2O
2-acylglycerophosphoserine + a carboxylate
-
low activity
-
?
1,2-dimyristoyl-sn-glycero-3-phosphate + H2O
?
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
?
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
?
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
?
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
-
-
-
?
1-palmitoyl-2-arachidonoyl-glycero-3-phosphoethanolamine + H2O
2-arachidonoyl-lysophosphatidylethanolamine + H2O
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
palmitic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
palmitic acid + 2-oleoylglycerophosphocholine
-
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
2-oleoylphosphatidylcholine + palmitate
-
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
2-oleoylphosphatidylcholine + palmitate
Trichoderma atroviride ZB-ZH292
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidic acid + H2O
2-oleyl-lysophosphatidic acid + palmitate
-
-
-
-
?
1-palmitoyl-2-oleyl-phosphatidic acid + H2O
2-oleyl-lysophosphatidic acid + palmitate
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphocholine + H2O
stearic acid + 2-arachidonoylglycerophosphocholine
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol
-
-
-
-
?
1-stearoyl-2-arachidonoylglycerophosphoinositol + H2O
stearic acid + 2-arachidonoylglycerophosphoinositol
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
-
-
-
-
?
dipalmitoylphosphatidylcholine + H2O
palmitic acid + 1-lyso-2-palmitoylphosphatidylcholine
-
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
best substrate
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
preferred substrate in vitro
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
preferred substrate in vitro
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acyl-lysophosphatidic acid + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acylglycerophosphatidic acid + a carboxylate
-
-
-
?
phosphatidic acid + H2O
2-acylglycerophosphatidic acid + a carboxylate
-
the catalytic preference for phosphatidic acid increases in the presence of membranes containing cholesterol, diacylglycerol, sn-1-stearoyl-2-arachidonoylphosphatidylethanolamine instead of sn-1-palmitoyl-2-oleeoylphosphatidylethanolamine and 10 mol% phosphatidic acid per 100 mol% total phosphoglycerides
-
?
phosphatidic acid + H2O
2-acylglycerophosphatidic acid + a carboxylate
-
-
-
-
?
phosphatidic acid + H2O
2-acylglycerophosphatidic acid + a carboxylate
-
-
-
-
?
phosphatidic acid + H2O
?
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidic acid + H2O
?
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidic acid + H2O
?
-
phosphatidic acid-specific isozymes mPA-PLA1alpha and mPA-PLA1beta
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
trivial name lecithin
trivial name lysolecithin
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
18fold lower initial rate than with phosphatidic acid
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
substrate from egg yolk
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
acidolysis, substrate from fish oil, fatty acid residue composition, overview, Thermomyces lanuginosus/Fusarium oxysporum enzyme mixture
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
very low activity
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
phosphatidylcholine from shark liver
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
7% of activity with phosphatidic acid, at 0.1% Triton X-100
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
substrate from egg yolk, the regiospecificity and hydrolysis profile of the enzyme is typical of a PLA1 enzyme generating lysophosphatidic acid, but not hydrolyzing the ester bond at the sn-2 position
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
substrate from egg yolk
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
acidolysis, substrate from fish oil, fatty acid residue composition, overview, Thermomyces lanuginosus/Fusarium oxysporum enzyme mixture
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a fatty acid anion
PLA1 displays a strong preference for phosphatidylcholine as a substrate
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a fatty acid anion
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a fatty acid anion
-
phosphatidylcholine is more easily hydrolyzed than phosphatidylethanolamine
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a fatty acid anion
-
-
-
-
?
phosphatidylcholine + H2O
2-acylglycerophosphocholine + a fatty acid anion
-
-
-
?
phosphatidylcholine + H2O
?
-
hydrolysis only if phosphatidylserine, phosphatidylethanolamine or phosphatidic acid is present
-
-
?
phosphatidylcholine + H2O
?
-
hydrolysis of L-phosphatidylcholine and not D-phosphatidylcholine
-
-
?
phosphatidylcholine + H2O
lysophosphatidylcholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
lysophosphatidylcholine + a carboxylate
-
-
-
-
?
phosphatidylcholine + H2O
lysophosphatidylcholine + fatty acid
-
intracellular phospholipase A1
-
-
?
phosphatidylcholine + H2O
lysophosphocholine + a carboxylate
-
milk, whey, and soy bean substrates
-
-
?
phosphatidylcholine + H2O
lysophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
lysophosphocholine + a carboxylate
TbPLA1 possesses an active-site serine residue, but is relatively insensitive to serine-modifying reagents such as di-isopropyl fluorophosphate and PMSF
-
-
?
phosphatidylcholine + H2O
lysophosphocholine + a carboxylate
-
-
-
?
phosphatidylcholine + H2O
lysophosphocholine + a carboxylate
TbPLA1 possesses an active-site serine residue, but is relatively insensitive to serine-modifying reagents such as di-isopropyl fluorophosphate and PMSF
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
Brucella melitensis bv. 1 ATCC 23456
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
similar activity as with phosphatidic acid
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
2-acylglycerophosphoethanolamine + a carboxylate
-
-
-
?
phosphatidylethanolamine + H2O
?
-
docosahexaenoic acid-enriched phosphatidylethanolamine vesicles
-
-
?
phosphatidylethanolamine + H2O
lysophosphatidylethanolamine + a carboxylate
-
milk, whey, and soy bean substrates
-
-
?
phosphatidylethanolamine + H2O
lysophosphatidylethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
lysophosphatidylethanolamine + a carboxylate
-
-
-
-
?
phosphatidylethanolamine + H2O
lysophosphatidylethanolamine + a fatty acid anion
-
-
-
-
?
phosphatidylethanolamine + H2O
lysophosphatidylethanolamine + a fatty acid anion
-
-
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-
?
phosphatidylinositol + H2O
?
-
hydrolysis only if phosphatidylserine, phosphatidylethanolamine or phosphatidic acid is present
-
-
?
phosphatidylinositol + H2O
?
-
intracellular phospholipase A1 recognizes the sn-1 position of phosphatidylinositol as its substrate, recombinant IPLA-1 hydrolyzes a fatty acid attached to phosphatidylinositol
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-
?
phosphatidylserine + H2O
?
-
in short incubation, 1-3 h, 2-acyllysophosphatidylserine is produced, in longer incubations the cis-unsaturated fatty acid is also released
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-
?
phosphatidylserine + H2O
?
-
phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A
-
-
?
phosphatidylserine + H2O
?
-
in short incubation, 1-3 h, 2-acyllysophosphatidylserine is produced, in longer incubations the cis-unsaturated fatty acid is also released
-
-
?
phosphatidylserine + H2O
?
-
docosahexaenoic acid-enriched phosphatidylserine vesicles
-
-
?
phosphatidylserine + H2O
?
-
phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A
-
-
?
phosphatidylserine + H2O
?
-
phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A
-
-
?
phosphatidylserine + H2O
?
-
phosphatidylserine-specific PLA1 isozyme PS-PLA1 or PLA1A
-
-
?
phosphatidylserine + H2O
lysophosphatidylserine + fatty acid
-
intracellular phospholipase A1
-
-
?
additional information
?
-
no substrate: tripalmitoylglycerol, cholesteryl oleate. Enzyme is sn-1 specific
-
-
?
additional information
?
-
-
no substrate: tripalmitoylglycerol, cholesteryl oleate. Enzyme is sn-1 specific
-
-
?
additional information
?
-
-
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
-
-
?
additional information
?
-
-
no activity with phosphatidylethanolamine and phosphatidic acid by intracellular phospholipase A1
-
-
?
additional information
?
-
catalyzes the hydrolysis of phospholipids at the sn-1 position
-
-
?
additional information
?
-
-
natural glycerophospholipids carrying a 1-acyl-bond are degraded in the following decreasing order of decreasing activity: phosphatidylcholine, phosphatidylinositol, 1-acyl-sn-glycero-3-phosphocholine, phosphatidylethanolamine, phosphatidylglycerol
-
-
?
additional information
?
-
-
no activity with 1-alkyl-2-acyl-sn-glycero-3-phosphocholine
-
-
?
additional information
?
-
-
the enzyme is activated by the binding of isoprenaline to beta2-adrenergic receptors
-
-
?
additional information
?
-
-
several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity
-
-
?
additional information
?
-
Corticium centrifugum
-
the enzyme also has lysophospholipase activity
-
-
?
additional information
?
-
-
release of lysophospholipids from the fat globule membrane decreasing the surface tension of skim milk and whey, overview, the enzyme improves foaming stability and properties of skim milk and whey, overview
-
-
?
additional information
?
-
-
distribution of phospholipids and lysophospholipids between fat globules and skim milk, foaming and surface properties, overview
-
-
?
additional information
?
-
-
isozyme mPA-PLA1beta is identical to the lipid defect locus lipase LPDL, encoded by gene lpd, homozygous insertion mutation leads to high levels of triacylglycerols in the plasma and hepatic steatosis
-
-
?
additional information
?
-
-
the enzyme plays an important role in the metabolism of high density lipoproteins, it may be responsible for the generation of docosahexaenoic acid DHA lysophospholipids in plasma, DHA is important in brain development and neurological function, the endothelial lipase is important in the delivery of DHA lysophospholipid carriers to the brain, overview
-
-
?
additional information
?
-
-
several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity
-
-
?
additional information
?
-
-
monoglyceride lipase does exhibit PLA1 activity
-
-
?
additional information
?
-
-
the enzyme is supposed to be responsible for the accumulation of lysophosphatidylcholine
-
-
?
additional information
?
-
-
the enzyme VipD possesses phospholipase A1 but not phospholipase A2 activity, EC 3.1.1.4
-
-
?
additional information
?
-
-
no activity with phosphatidylcholine or triolein
-
-
?
additional information
?
-
-
the enzyme exhibits both phospholipase A1 and phospholipase A2 activity
-
-
?
additional information
?
-
-
the enzyme is important in phospholipid catabolism and the remodeling of the acyl groups of phospholipids
-
-
?
additional information
?
-
-
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
-
-
?
additional information
?
-
-
the enzyme exhibits both phospholipase A1 and phospholipase A2 activity
-
-
?
additional information
?
-
-
isozyme mPA-PLA1beta might plays a role in tumor progression
-
-
?
additional information
?
-
-
several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity
-
-
?
additional information
?
-
-
the enzyme hydrolyzes sn-1 ester bonds about 2000 times more efficiently than sn-2 ones, the enzyme exhibits weak, but significant sn-1 lysophospholipase activity
-
-
?
additional information
?
-
-
several isozymes with different substrate specificities, overview, endothelial lipase hepatic lipase, and PLRP2 also exhibit triacylglycerol-hydrolyzing activity
-
-
?
additional information
?
-
His21 and Cys111 of H-Rev107 form a catalytic dyad. The N-terminal proline-rich and C-terminal hydrophobic domains are involved in the catalytic activity and/or proper folding
-
-
?
additional information
?
-
-
the Rickettsia prowazekii RP534 protein possesses phospholipase A1, i.e. PLA1, PLA2, and Lyso-PLA2 activities and can function in the absence of any eukaryotic cofactors in vitro, overview. RP534 protein is a homologue of the Pseudomonas aeruginosa ExoU phospholipase A secreted cytotoxin
-
-
?
additional information
?
-
-
enzyme displays sn-1-specific activity toward phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid, generating 2-acyl lysophospholipids
-
-
?
additional information
?
-
-
enzyme displays sn-1-specific activity toward phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid, generating 2-acyl lysophospholipids
-
-
?
additional information
?
-
the enzyme preferentially hydrolyzes the sn-1 acyl ester in glycerophospholipids, yielding a fatty acid and 2-acyl-lysophospholipid, molecular mechanism underlying the substrate binding by the enzyme, overview
-
-
?
additional information
?
-
the substrate specificity is pH-dependent, the enzyme preferably hydrolyzes phosphatidic acid and phosphatidylserine at pH 7.2, it is active with lysophosphatidylcholine, but not with triglyceride and the 4-nitrophenyl ester of fatty acids, substrate specificity, overview. At the reaction equilibrium, the molar ratio of released free fatty acids (sn-1:sn-2) is 63:37
-
-
?
additional information
?
-
-
the substrate specificity is pH-dependent, the enzyme preferably hydrolyzes phosphatidic acid and phosphatidylserine at pH 7.2, it is active with lysophosphatidylcholine, but not with triglyceride and the 4-nitrophenyl ester of fatty acids, substrate specificity, overview. At the reaction equilibrium, the molar ratio of released free fatty acids (sn-1:sn-2) is 63:37
-
-
?
additional information
?
-
the enzyme preferentially hydrolyzes the sn-1 acyl ester in glycerophospholipids, yielding a fatty acid and 2-acyl-lysophospholipid, molecular mechanism underlying the substrate binding by the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme preferentially hydrolyzes the sn-1 acyl ester in glycerophospholipids, yielding a fatty acid and 2-acyl-lysophospholipid, molecular mechanism underlying the substrate binding by the enzyme, overview
-
-
?
additional information
?
-
the substrate specificity is pH-dependent, the enzyme preferably hydrolyzes phosphatidic acid and phosphatidylserine at pH 7.2, it is active with lysophosphatidylcholine, but not with triglyceride and the 4-nitrophenyl ester of fatty acids, substrate specificity, overview. At the reaction equilibrium, the molar ratio of released free fatty acids (sn-1:sn-2) is 63:37
-
-
?
additional information
?
-
-
the substrate specificity is pH-dependent, the enzyme preferably hydrolyzes phosphatidic acid and phosphatidylserine at pH 7.2, it is active with lysophosphatidylcholine, but not with triglyceride and the 4-nitrophenyl ester of fatty acids, substrate specificity, overview. At the reaction equilibrium, the molar ratio of released free fatty acids (sn-1:sn-2) is 63:37
-
-
?
additional information
?
-
-
the enzyme is a triacylglycerol lipase, EC 3.1.1.3, that is a carboxylester hydrolases catalyzing the hydrolysis of long-chain acylglycerols, but it is also active on phosphatidylcholine to a lesser extent
-
-
?
additional information
?
-
-
Val260 residue in enzyme's lid is critical for the interaction with lipid substrate, molecular dynamics calculations of lipase-phospholipid transition-state complexes in substrate binding determining the substrate specificity with phospholipids, molecular dynamics simulations, overview. Hydrolysis of egg yolk phosphatidylcholine by the enzyme shows a triphasic kinetic pattern
-
-
?
additional information
?
-
-
the parasite enzyme of the infective stages generates lipid messengers that activate host cell protein kinase C, infection of Vero cells with the pathogen leads to an altered lipid composition with the appearance of free fatty acids, diacylglycerol, and lysophosphatidylcholine, overview, the enzyme might play an important role in host cell-parasite interaction preceding invasion
-
-
?
