3.1.1.22: hydroxybutyrate-dimer hydrolase
This is an abbreviated version!
For detailed information about hydroxybutyrate-dimer hydrolase, go to the full flat file.
Word Map on EC 3.1.1.22
Reaction
Synonyms
3-HB-oligomer hydrolase, 3-hydroxybutyrate oligomer hydrolase, 3-hydroxybutyrate-oligomer hydrolase, 3HB oligomer hydrolase, 3HB-oligomer hydrolase, 3HBOH, D(-)-3-hydroxybutyrate oligomer hydrolase, D-(-)-3-hydroxybutyrate oligomer hydrolase, D-(-)-3-hydroxybutyrate-dimer hydrolase, H16 A2862, hydrolase, hydroxybutyrate dimer, intracellular PHB depolymerase, More, PhaZ, PhaZ1, PhaZ2, PhaZc, phaZre, poly[D-(-)-3-hydroxybutyrate] depolymerase
ECTree
3.1.1.22 hydroxybutyrate-dimer hydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.1.22 - hydroxybutyrate-dimer hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-3-((S)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate + (S)-3-hydroxybutanoate
(S)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate + (S)-3-hydroxybutanoate
-
i.e. L-(+)-3-[D-(-)-hydroxybutuyryloxy]butyric acid
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
75% of the activity with 4-nitrophenyl butyrate
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best 4-nitrophenyl ester substrate
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
43% of the activity with 4-nitrophenyl butyrate
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
81% of the activity with 4-nitrophenyl butyrate
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
involved in the degradation of poly-3-hydroxybutyrate (PHB)
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
involved in the degradation of poly-3-hydroxybutyrate (PHB)
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
involved in the degradation of poly-3-hydroxybutyrate (PHB)
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
involved in the degradation of poly-3-hydroxybutyrate (PHB)
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
involved in the degradation of poly-3-hydroxybutyrate (PHB)
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)11butanoate + H2O
(R)-3-hydroxybutanoate
-
exo-type hydrolysis from the carboxyl terminus
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)11butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)11butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)11butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
exo-type hydrolysis from the carboxyl terminus
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)2butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate
?
-
degradation of poly-(3-hydroxybutyrate)
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate
?
-
degradation of poly-(3-hydroxybutyrate)
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate
?
-
degradation of poly-(3-hydroxybutyrate)
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate
?
-
degradation of poly-(3-hydroxybutyrate)
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate + H2O
(R)-3-hydroxybutanoate
-
exo-type hydrolysis from the carboxyl terminus
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)3butanoate + H2O
(R)-3-hydroxybutanoate
-
attack from th free hydroxyl terminus, releasing monomer units one at a time
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)4butanoate + H2O
(R)-3-hydroxybutanoate
-
exo-type hydrolysis from the carboxyl terminus
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)4butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)4butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)4butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)7butanoate + H2O
(R)-3-hydroxybutanoate
-
exo-type hydrolysis from the carboxyl terminus
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)7butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)7butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)7butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
i.e. D-(-)-3-[hydroxybutuyryloxy]butyric acid
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
preferred substrate
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
-
-
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
i.e. D-(-)-3-[hydroxybutuyryloxy]butyric acid
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
i.e. D-(-)-3-[hydroxybutuyryloxy]butyric acid
-
?
(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate
-
i.e. D-(-)-3-[hydroxybutuyryloxy]butyric acid
-
?
(R)-3-((S)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate + (S)-3-hydroxybutanoate
-
i.e. D-(-)-3-[L-(+)-hydroxybutuyryloxy]butyric acid
-
?
(R)-3-((S)-3-hydroxybutanoyloxy)butanoate + H2O
(R)-3-hydroxybutanoate + (S)-3-hydroxybutanoate
-
i.e. D-(-)-3-[L-(+)-hydroxybutuyryloxy]butyric acid
-
?
3-(3-hydroxybutanoyloxy)butanoate + H2O
3-hydroxybutanoate
-
-
-
?
3-(3-hydroxybutanoyloxy)butanoate + H2O
3-hydroxybutanoate
-
-
-
?
3-(3-hydroxypentanoyloxy)pentanoate + H2O
3-hydroxypentanoate
-
-
-
?
3-(3-hydroxypentanoyloxy)pentanoate + H2O
3-hydroxypentanoate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
60% of the activity with 4-nitrophenyl butyrate
-
?
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
-
?
additional information
?
-
-
hydrolyzes exclusively 3-hydroxybutyrate-dimers and trimers, no hydrolysis of longer linear or cyclic oligomers
-
-
?
additional information
?
-
-
hydrolyzes 3-hydroxybutyrate-dimers, trimers, tetramers, pentamers and cyclic trimers, pentamers and hexamers at a similar efficiency
-
-
?
additional information
?
-
enzyme PhaZ1 converts the polymer into oligomers and monomers of hydroxybutyrate by the end of the degradation process
-
-
?
additional information
?
-
enzyme PhaZ1 converts the polymer into oligomers and monomers of hydroxybutyrate by the end of the degradation process
-
-
?
additional information
?
-
-
enzyme PhaZ1 converts the polymer into oligomers and monomers of hydroxybutyrate by the end of the degradation process
-
-
?
additional information
?
-
the enzyme shows no activity with 3HB oligomers or poly(hydroxybutyrate), PHB, granules
-
-
?
additional information
?
-
-
the enzyme shows no activity with 3HB oligomers or poly(hydroxybutyrate), PHB, granules
-
-
?
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
hydrolyzes 3-hydroxybutyrate-dimers, trimers, tetramers, pentamers and cyclic trimers, pentamers and hexamers at a similar efficiency
-
-
?
additional information
?
-
pHB and PHV granules are not depolymerized by the enzyme
-
-
?
additional information
?
-
-
pHB and PHV granules are not depolymerized by the enzyme
-
-
?
additional information
?
-
pHB and PHV granules are not depolymerized by the enzyme
-
-
?
additional information
?
-
-
hydrolyzes 3-hydroxybutyrate-dimers, trimers, tetramers, pentamers and cyclic trimers, pentamers and hexamers at a similar efficiency
-
-
?
additional information
?
-
-
hydrolyzes 3-hydroxybutyrate-dimers, trimers, tetramers, pentamers and cyclic trimers, pentamers and hexamers at a similar efficiency
-
-
?
