3.1.1.22: hydroxybutyrate-dimer hydrolase

This is an abbreviated version!
For detailed information about hydroxybutyrate-dimer hydrolase, go to the full flat file.

Word Map on EC 3.1.1.22

Reaction

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate
+
H2O
= 2 (R)-3-hydroxybutanoate

Synonyms

More, D-(-)-3-hydroxybutyrate-dimer hydrolase, 3HB-oligomer hydrolase, hydrolase, hydroxybutyrate dimer, D-(-)-3-hydroxybutyrate oligomer hydrolase, 3HB oligomer hydrolase, D(-)-3-hydroxybutyrate oligomer hydrolase, PhaZ1, PhaZ, 3-hydroxybutyrate-oligomer hydrolase, 3-HB-oligomer hydrolase, 3HBOH, 3-hydroxybutyrate oligomer hydrolase, PhaZc, PhaZ2, H16 A2862, poly[D-(-)-3-hydroxybutyrate] depolymerase, intracellular PHB depolymerase, phaZre

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.22 hydroxybutyrate-dimer hydrolase

Inhibitors

Inhibitors on EC 3.1.1.22 - hydroxybutyrate-dimer hydrolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
diisopropylfluorophosphate
EDTA
-
inhibition after prolonged incubation
iodoacetamide
N-ethylmaleimide
74.8% residual activity at 1 mM
NEM
-
13% inhibition at 1 mM
phenylmethylsulfonyl fluoride
27.4% residual activity at 1 mM
Phenylmethylsulfonylfluoride
-
10 mM, 50% enzyme activity inhibited
PMSF
-
92% inhibition at 1 mM
SDS
61.1% residual activity at 0.05% (w/v)
Triton X-100
67.3% residual activity at 0.05% (v/v)
additional information
-
not inhibited by 1,4-dimercapto-2,3-butanediol; not inhibited by (p-tert-octylphenoxy)polyethoxyethanol
-