1.13.11.66: hydroquinone 1,2-dioxygenase

This is an abbreviated version!
For detailed information about hydroquinone 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.66

Reaction

benzene-1,4-diol
+
O2
=
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate

Synonyms

HQDO, hydroquinone 1,2-dioxygenase, hydroquinone dioxygenase, LinE, mnpC, PcpA, PdcDE, PnpC1, PnpC2, PnpCD, two-subunit hydroquinone 1,2-dioxygenase, type II HQDO, YaiA

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.66 hydroquinone 1,2-dioxygenase

Substrates Products

Substrates Products on EC 1.13.11.66 - hydroquinone 1,2-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,3-difluorohydroquinone + O2
?
show the reaction diagram
2,5-difluorohydroquinone + O2
?
show the reaction diagram
2,5-dimethylhydroquinone + O2
2-methylmaleylacetone
show the reaction diagram
2,6-dibromohydroquinone + O2
2-bromomaleylacetate + Br-
show the reaction diagram
-
-
-
?
2,6-dichloro-p-hydroquinone + O2
2-chloromaleylacetate + Cl-
show the reaction diagram
-
-
-
?
2,6-dichlorohydroquinone + O2
2-chloromaleylacetate + Cl-
show the reaction diagram
complete conversion of substrate
-
-
?
2,6-dichlorohydroquinone + O2
?
show the reaction diagram
-
-
0.5-0.6 equiv. of chloride is released during turnover of substrate
-
?
2,6-dimethylhydroquinone + O2
2-methylmaleylacetone + ?
show the reaction diagram
-
-
-
?
2-(1-methyl1-octyl)-hydroquinone + O2
?
show the reaction diagram
2-chloro-6-methylhydroquinone
?
show the reaction diagram
-
complete conversion of substrate, yields a mixture of 1,2- and 1,6-cleavage products. The two modes of cleavage have different Km values for oxygen, consistent with a mechanism in which the substrate binds in two catalytically productive orientations
-
?
2-chlorohydroquinone + O2
?
show the reaction diagram
2-ethylhydroquinone + O2
?
show the reaction diagram
2-hexylhydroquinone + O2
?
show the reaction diagram
2-methoxyhydroquinone + O2
?
show the reaction diagram
59% of the activity with hydroquinone
-
-
?
2-methylhydroquinone + O2
?
show the reaction diagram
2-methylhydroquinone + O2
maleylacetone
show the reaction diagram
-
-
-
-
?
2-pentylhydroquinone + O2
?
show the reaction diagram
19% of the activity with hydroquinone
-
-
?
2-propylhydroquinone + O2
?
show the reaction diagram
23% of the activity with hydroquinone
-
-
?
2-tert-butylhydroquinone + O2
?
show the reaction diagram
5% of the activity with hydroquinone
-
-
?
3,5-difluorohydroquinone + O2
?
show the reaction diagram
4-nitrophenol + O2
?
show the reaction diagram
C1I210; C1I209
-
-
-
?
benzene-1,4-diol + O2
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate
show the reaction diagram
bromohydroquinone + O2
?
show the reaction diagram
bromohydroquinone + O2
maleylacetate + Br-
show the reaction diagram
-
-
-
?
chlorohydroquinone + O2
?
show the reaction diagram
-
70% of the activity with hydroquinone
-
-
?
chlorohydroquinone + O2
maleylacetate + Cl-
show the reaction diagram
-
-
-
?
hydroquinone + O2
4-hydroxymuconic acid semialdehyde
show the reaction diagram
hydroquinone + O2
4-hydroxymuconic semialdehyde
show the reaction diagram
hydroquinone + O2
gamma-hydroxymuconic acid semialdehyde
show the reaction diagram
methoxyhydroquinone + O2
?
show the reaction diagram
-
50% of the activity with hydroquinone
-
-
?
methylhydroquinone + O2
?
show the reaction diagram
methylhydroquinone + O2
maleylacetone + ?
show the reaction diagram
-
-
-
?
additional information
?
-