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ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)n+m
-
NAD+-dependent DNA ligase LigN is non-essential for cell viability. Haloferax volcanii also encodes the ATP-dependent DNA ligase LigA. As with LigN, LigA is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function
-
-
?
ATP + 5'-phosphate terminus of deoxyribonucleotides
?
ATP + 5'-phosphoryl termini of poly(dA-dT)
?
-
-
-
-
?
ATP + acridinium-ester labelled DNA
?
-
-
-
-
?
ATP + nicked DNA
AMP + diphosphate + ?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
NAD+ + 5'-d(ACCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
NAD+ + 5'-d(GCCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
NAD+ + deoxyribonucleotide
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
NADH + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
NADH has a significantly higher Km as NAD+
-
-
?
Thionicotinamide derivative of NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
significantly higher Km as NAD+
-
-
?
additional information
?
-
ATP + 5'-phosphate terminus of deoxyribonucleotides
?
-
-
-
-
?
ATP + 5'-phosphate terminus of deoxyribonucleotides
?
-
-
-
-
?
ATP + 5'-phosphate terminus of deoxyribonucleotides
?
-
-
-
-
?
ATP + 5'-phosphate terminus of deoxyribonucleotides
?
-
-
-
-
?
ATP + nicked DNA
?
-
-
-
?
ATP + nicked DNA
?
-
-
-
-
?
ATP + nicked DNA
?
-
-
-
-
?
ATP + nicked DNA
?
-
-
-
?
ATP + nicked DNA
?
-
-
-
-
?
ATP + nicked DNA
AMP + diphosphate + ?
-
-
-
?
ATP + nicked DNA
AMP + diphosphate + ?
-
-
-
-
?
ATP + nicked DNA
AMP + diphosphate + ?
-
-
-
?
ATP + nicked DNA
AMP + diphosphate + ?
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
DNA ligase plays the key role in DNA replication of joining the nascent small pieces of DNA at the replication fork. The enzyme participates in the synthesis and repair of DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
the enzyme is indispensable for normal cell growth and inviability of mutants seems to be primarily the result of an inability to seal Okazaki fragments
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
the enzyme plays a pivotal role in DNA replication, repair and recombination
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
Tequatrovirus T4
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
activity depends on the base pairs on both sides of the nick, T/A
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
joining of a single-strand-scission in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
bacteriophage T5 DNA, which contains single strand interruptions at defined positions in one of the complementary strands
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA ligase requires two DNA termini, the 5'-terminus, carrying a phosphate group, and the 3'-terminus, a hydroxyl group. These termini must reside on a double-stranded molecule, DNA:DNA or DNA:RNA. Both strands of the duplex may terminate, in the form of a staggered end or a blunt end, and the ligase then requires a second similar double-stranded terminus to join the two in an intermolecular reaction. Alternatively, the two termini may be provided by a nick in just one strand of a duplex, which the enzyme will then seal
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
joining of the 5'-phosphoryl of a DNA chain to the 3'-hydroxyl of an RNA molecule in two ways: 1. Oligo(A) is joined to the 5'-phosphoryl of oligo(dA) on a poly(dT) template strand. 2. the enzyme can circularize poly[d(A-T)]pU in which UMP occupies the 3'-hydroxyl terminal position
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
blunt-end ligation in presence of macromolecular solutes, inactive in absence
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
oligonucleotides as short as six or seven in length can be joined if annealed to long complementary deoxyribonucleotides
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
joining of 5'-phosphoryl terminus of DNA chain to the 3'-hydroxyl terminus of RNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA ligase requires two DNA termini, the 5'-terminus, carrying a phosphate group, and the 3'-terminus, a hydroxyl group. These termini must reside on a double-stranded molecule, DNA:DNA or DNA:RNA. Both strands of the duplex may terminate, in the form of a staggered end or a blunt end, and the ligase then requires a second similar double-stranded terminus to join the two in an intermolecular reaction. Alternatively, the two termini may be provided by a nick in just one strand of a duplex, which the enzyme will then seal
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
formation of linear oligomers by intermolecular cohesive-end ligation
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
the self-complementary polymer, poly(dA-dT), forms a looped-back structure that DNA ligase can join to yield a circular molecule
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
joins oligo(dT) that is base-paired to poly(dA) or oligo(dA) base-paired to poly(dT)
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
PvuII endonuclease-digested pBR322 DNA, formation of linear oligomers ranging from dimer through pentamer
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
formation of linear oligomers by intermolecular blunt-end ligation in presence of high concentrations of polymer polyethylene glycol
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
catalyzes the joining of polynucleotide strands provided they have juxtaposed 3'-hydroxyl and 5'-phosphoryl end groups aligned in a duplex structure: e.g. annealed ends of lamdda DNA, endogenous nicks in T5 DNA, interruptions created by the action of pancreatic DNAse, annealed fragments generated by the staggered cutting action of some restriction endonucleases
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
no ligation of blunt-ended or flush-ended DNAs
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
the enzyme seals sticky ends efficiently, but has little activity on 1-nucleotide gap or blunt-ended DNA substrates even in presence of polyethylene glycol. MsEPV DNA ligase readily joins DNA nicks with mismatches at either side of the nick junction, except for mismatches at the nick junction containing an A base in the template strand (A/A, G/A, and C/A). The enzyme can join DNA probes on RNA templates. MsEPV DNA ligase joins mismatches at the 3' side of the nick more frequently than at the 5' side of the nick on an RNA template. No activity with ATP
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
LigA is essential for growth of Mycobacterium tuberculosis
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
nick-closing activity
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA ligase requires two DNA termini, the 5'-terminus, carrying a phosphate group, and the 3'-terminus, a hydroxyl group. These termini must reside on a double-stranded molecule, DNA:DNA or DNA:RNA. Both strands of the duplex may terminate, in the form of a staggered end or a blunt end, and the ligase then requires a second similar double-stranded terminus to join the two in an intermolecular reaction. Alternatively, the two termini may be provided by a nick in just one strand of a duplex, which the enzyme will then seal
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
acridinium-ester labelled DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
Hind III digested plasmid
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
Hind III digested plasmid
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
nick-closing activity
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
(dT)8, (dT)10, (dT)12-18
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
blunt-end ligation, intermolecular joining to yield linear oligomers, but no circular DNA forms in presence of high concentrations of polyethylene glycols
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA ligase requires two DNA termini, the 5'-terminus, carrying a phosphate group, and the 3'-terminus, a hydroxyl group. These termini must reside on a double-stranded molecule, DNA:DNA or DNA:RNA. Both strands of the duplex may terminate, in the form of a staggered end or a blunt end, and the ligase then requires a second similar double-stranded terminus to join the two in an intermolecular reaction. Alternatively, the two termini may be provided by a nick in just one strand of a duplex, which the enzyme will then seal
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
cohesive-end DNA restriction fragments
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
nick-closing activity
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
nick-closing activity
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
cohesive ends of restriction endonuclease digested lambda-DNA
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Oleidesulfovibrio alaskensis
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Wolbachia sp. subsp. Brugia malayi
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Wolbachia sp. subsp. Brugia malayi TRS
-
-
-
?
NAD+ + 5'-d(ACCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
Tequatrovirus T4
-
100% ligation efficiency
-
-
?
NAD+ + 5'-d(ACCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
-
100% ligation efficiency
-
-
?
NAD+ + 5'-d(GCCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
Tequatrovirus T4
-
100% ligation efficiency
-
-
?
NAD+ + 5'-d(GCCATTCCTGATTCTAAGTG)-3' + 5'-d(CTCAGGTCGACAGTCTGCGG)-3'
?
-
100% ligation efficiency
-
-
?
NAD+ + deoxyribonucleotide
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + deoxyribonucleotide
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
additional information
?
-
-
NAD+/nicotinamide nucleotide exchange reaction
-
-
?
additional information
?
-
-
no activity with NADH, NADP, NADPH, ATP and AMP
-
-
?
additional information
?
-
-
the enzyme is relatively tolerant of 5'-phosphate base mispairs and 5' N:abasic lesions
-
-
?
additional information
?
-
-
purified DNA ligase exhibits activity on DNA fragments with cohesive termini, and no activity is detected on blunt-end DNA. DNA ligase promotes the amplification of long DNA fragments from the genomic DNA of Thermotoga maritima
-
-
?
additional information
?
-
-
purified DNA ligase exhibits activity on DNA fragments with cohesive termini, and no activity is detected on blunt-end DNA. DNA ligase promotes the amplification of long DNA fragments from the genomic DNA of Thermotoga maritima
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)n+m
-
NAD+-dependent DNA ligase LigN is non-essential for cell viability. Haloferax volcanii also encodes the ATP-dependent DNA ligase LigA. As with LigN, LigA is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
NAD+ + deoxyribonucleotide
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
DNA ligase plays the key role in DNA replication of joining the nascent small pieces of DNA at the replication fork. The enzyme participates in the synthesis and repair of DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
the enzyme is indispensable for normal cell growth and inviability of mutants seems to be primarily the result of an inability to seal Okazaki fragments
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
joining of short DNA fragments formed during DNA replication and so enabling DNA synthesis to progress in an overall 3'-5' direction on the antiparallel strand of the double helix, while continual 5'-3' synthesis proceeds on the other strand. Plays a role during genetic recombination and in the repair of UV-damaged DNA
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
-
the enzyme plays a pivotal role in DNA replication, repair and recombination
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
LigA is essential for growth of Mycobacterium tuberculosis
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
although NAD+-dependent DNA ligase is essential for mycobacterial viability, only low levels of protein are required for growth
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
DNA-repair, phosphodiester bond formation between adjacent 5'-phosphate and 3'-hydroxyl groups in double-stranded DNA
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Oleidesulfovibrio alaskensis
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Wolbachia sp. subsp. Brugia malayi
-
-
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
Wolbachia sp. subsp. Brugia malayi TRS
-
-
-
?
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(29S,34S,36R,37R)-1,1'-(1,3-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-hydroxypropyl)urea)
-
(29S,34S,36R,37R)-1,1'-(1,4-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-ethoxy-3-oxopropyl)urea)
-
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
(3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxamide
-
-
(3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxylic acid
-
-
(3S,3'R)-3,3'-(propane-1,3-diyldiimino)bis[3-[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]propan-1-ol]
-
(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)acetonitrile
-
-
(4R)-N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine
-
-
(8R,10R)-10-((4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-hydroxymethoxymethyl-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione
IC50: 0.005 mM
(NH4)2SO4
-
(NH4)2SO4 concentrations higher than 30 mM are inhibitory. At 100 mM KCl, concentrations of (NH4)2SO4 above 12 mM are inhibitory
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one
Wolbachia sp. subsp. Brugia malayi
-
1-(4-aminopiperidin-1-yl)-6-(6,7-dihydro-12H-benzo[2,3]oxepino[4,5-b]indol-12-yl)-hexane-2-ol
-
-
1-(4-aminopiperidin-1-yl)-6-(dibenzo[b,e][1,4]oxazepin-5(11H)-yl)hexan-2-ol
-
-
12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole
-
2,2'-([4-[(6-chloro-2-methoxyacridin-9-yl)amino]pentyl]imino)diethanol
-
-
2,4-diamino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
2,4-diamino-7-dimethylamino-pyrimido[4,5-d]pyrimidine
-
IC50 of 0.0001 mg/ml, specific inhibitor of NAD+-dependent DNA ligase, inhibits competitively with respect to NAD+ and specifically inhibits enzyme adenylation, but not DNA adenylation or ligation
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one
Wolbachia sp. subsp. Brugia malayi
-
2-(butylsulfanyl)-5'-deoxyadenosine
2-(butylsulfanyl)-5-hydroadenosine
-
2-(butylsulfanyl)adenosine
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
2-(cyclopentyloxy)-5'-deoxyadenosine
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
2-(cyclopentyloxy)adenosine
2-(cyclopentylsulfanyl)adenosine
2-(pentylsulfanyl)adenosine
2-amino-5-(2-hydroxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5-(2-methoxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5-(aminomethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
2-amino-5-phenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5-[(3R)-3-aminopyrrolidin-1-yl]-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-5H-chromeno[2,3-b]pyridine-3-carboxamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
2-amino-6,7-dimethoxyquinoline-3-carboxamide
2-amino-6-(2-phenylethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-(hydroxymethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-(propan-2-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-benzyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-benzyl-7-chloro-5-methyl-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-5-(3-hydroxyazetidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-5-(4-hydroxypiperidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-5-[(2-hydroxyethyl)(methyl)amino]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-5-[(3R)-3-hydroxypyrrolidin-1-yl]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-7-cyclopentyl-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-bromo-7-tert-butyl-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-chloro-5-ethyl-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-cyclopentyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-cyclopropyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-ethenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-ethyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-6-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-7,8-difluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations, worse inhibitor than 2-amino-7-fluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide
2-amino-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-7-chloro-5-methyl-6-(prop-2-en-1-yl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-7-chloro-5-methyl-6-(pyridin-4-ylmethyl)-1,8-naphthyridine-3-carboxamide
-
-
2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations, better inhibitor than 2-amino-7,8-difluoro-5-oxo-4a,10a-dihydro-5H-chromeno[2,3-b]pyridine-3-carboxamide
2-amino-7-[2-(benzyloxy)propan-2-yl]-6-bromo-1,8-naphthyridine-3-carboxamide
-
-
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
2-[(decahydronaphthalen-2-yl)oxy]adenosine
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
3,3'-(decane-1,10-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propan-1-ol)
-
3,3'-(propane-1,3-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[2,3-d][1,3]dioxol-5-yl)propan-1-ol)
-
3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(3-phenoxymethyl-thioureido)-propionic acid ethyl ester
IC50: 0.004 mM
3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-[3-(3-{3-[1-((S)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-ethoxycarbonyl-ethyl]-ureido}-phenyl)-ureido]-propionic acid ethyl ester
IC50: 0.0277 mM
3-(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)propanenitrile
-
-
3-amino-6-[(6-chloro-2-methoxyacridin-9-yl)amino]heptan-1-ol
-
-
3-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-7-methoxyacridin-2-aminium
-
-
3-chloro-N9-[5-(diethylamino)pentan-2-yl]-7-methoxyacridine-2,9-diamine
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
4-([4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)benzoic acid
-
-
4-amino-2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
4-amino-2-(2-fluoroethoxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-(cyclopentylamino)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-(cyclopentyloxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-(cyclopentylsulfanyl)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-(cyclopentylsulfanyl)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
4-amino-2-[(1,3-difluoropropan-2-yl)oxy]-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-[(2,4-dimethylcyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-[(2-methylcyclohexyl)oxy]-8-(1H-pyrazol-4-ylmethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-[(2-methylcyclohexyl)oxy]-8-[(1R,5R)-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-2-[(4-chlorocyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
4-amino-6-(1H-benzimidazol-2-yl)pyridazin-3(2H)-one
-
-
4-amino-8-(2,3-dihydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-(2-hydroxyethyl)-2-(2-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-(2-hydroxyethyl)-2-(4-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-(2-hydroxyethyl)-2-(propan-2-yloxy)pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-(3-fluoro-2-hydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-(cyclopent-3-en-1-ylmethyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(1R)-2-hydroxycyclopentyl]-2-[[4-(trifluoromethyl)cyclohexyl]oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(1S)-2,3-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(1S,2S)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(2R)-2-hydroxycyclohexyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(2R)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(2S,5S)-2,5-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[(3,4-dihydroxycyclopentyl)methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[[(2R)-2-hydroxycyclopentyl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-8-[[(4S)-4-hydroxytetrahydrofuran-3-yl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
-
-
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
4-aminothieno[3,2-c]pyridine-7-carboxamide
5'-deoxy-2-(pentyloxy)adenosine
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
5'-deoxy-2-phenoxyadenosine
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
5-([4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)thiophene-2-carboxylic acid
-
-
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
5-[[[(4-chlorophenyl)amino]carbonyl](phenylmethyl)amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-3-O-(phenylmethyl)-alpha-L-gluco-heptofuranuronic acid ethyl ester
IC50: 0.00965 mM
6-(dibenzo[b,f][1,4]oxazepin-10(11H)-yl)-1-(piperidin-1-yl)hexan-2-ol
-
-
6-chloro-2-methoxy-N-[4-(piperidin-1-yl)pentyl]acridin-9-amine
-
-
6-chloro-9-[[5-(diethylammonio)pentan-2-yl]amino]-2-methoxyacridinium
-
-
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
7-methoxy-6-methylpteridine-2,4-diamine
-
-
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
8-hydroxyquinoline-2-carboxylic acid
8-methoxy-2,3-dimethylquinoxalin-5-ol
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
ADP
-
inhibits adenylation reaction
cAMP
-
inhibits adenylation reaction
Chloroquine diphosphate
-
IC50: 0.0014 mM
deoxyribonucleotide
-
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
ethyl 3-(1-benzyl-3-(4-chlorophenyl)ureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate
-
ethyl 3-(3-benzoylthioureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate
-
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
ethyl-3-O-benzyl-5,6-dideoxy-1,2-O-(1-methylethylidene)-5-[[(phenylcarbonyl)carbamoyl]amino]-alpha-L-xylo-heptofuranuronate
-
ethyl-3-O-benzyl-5-[benzyl[(4-chlorophenyl)carbamoyl]amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-alpha-L-xylo-heptofuranuronate
-
KCl
-
inhibition by KCl occurs at greater than 30 mM (NH4)2SO
methotrexate
-
IC50 of 0.008 mg/ml
mitonafide
-
i.e. 3-nitro-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide
Mn2+
-
activation at 0.2-1.0 mM, inhibition at higher concentration
N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylbutane-1,4-diamine
-
-
N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-dimethylbutane-1,4-diamine
-
-
N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-6-yl]sebacamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-8-yl]adipamide
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
N,N'-bis[[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl]dodecane-1,12-diamine
-
N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine
-
-
N,N-bis(4-aminobutyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine
-
-
N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine
-
-
N-(4-aminobutyl)-N-(3-aminopropyl)-N'-(6-chloro-2-methoxyacridin-9-yl)pentane-1,5-diamine
-
-
N-(4-aminobutyl)-N-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]butane-1,4-diamine
-
-
N-(6-chloro-2-methoxyacridin-9-yl)butane-1,4-diamine
-
-
N-[6-piperidin-1-ylhexyl]-6,7-dihydrobenzo[b]indolo[2,3-d]thiepine
LX competes with NAD+ andf inhibits the enzyme with IC50 in the low micromolar range, LX exhibits around 15fold better inhibition of the Mycobacterium tuberculosis enzyme compared to the human DNA ligase
N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine
-
-
N1-(7-chloro-[4]quinolyl)-N4,N4-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine
IC50: 0.046 mM
N4-(7-chloro-7,8-dihydroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
-
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine
-
NAD+
-
inhibitory above 0.1 mM, activity is abolished at 0.5 mM
nicotinamide mononucleotide
-
-
pinafide
-
i.e. 3-nitro-N-(2-(1-pyrrolidinyl)ethyl)-1,8-naphthalimide
pyridochromanone
-
IC50: 0.0006 mM
pyridochromanones
-
differently substituted compounds tested and all found to be inhibitory, competitive with NAD+, inhibitory in nano-molar rage without affecting human DNA-ligase (ATP-depentend) activity
-
tert-butyl 3-(7-amino-3-bromo-6-carbamoyl-1,8-naphthyridin-2-yl)azetidine-1-carboxylate
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
-
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
-
-
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
-
-
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
-
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
-
-
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
-
-
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
-
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
-
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
-
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
-
2-(butylsulfanyl)-5'-deoxyadenosine
-
-
2-(butylsulfanyl)-5'-deoxyadenosine
-
-
2-(butylsulfanyl)-5'-deoxyadenosine
-
-
2-(butylsulfanyl)-5'-deoxyadenosine
-
-
2-(butylsulfanyl)-5'-deoxyadenosine
-
-
2-(butylsulfanyl)adenosine
-
-
2-(butylsulfanyl)adenosine
-
-
2-(butylsulfanyl)adenosine
-
-
2-(butylsulfanyl)adenosine
-
-
2-(butylsulfanyl)adenosine
-
-
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
-
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-5'-deoxyadenosine
-
-
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
-
-
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
-
-
2-(cyclopentyloxy)adenosine
-
-
2-(cyclopentyloxy)adenosine
-
-
2-(cyclopentyloxy)adenosine
-
-
2-(cyclopentyloxy)adenosine
-
-
2-(cyclopentyloxy)adenosine
-
-
2-(cyclopentylsulfanyl)adenosine
-
-
2-(cyclopentylsulfanyl)adenosine
-
-
2-(cyclopentylsulfanyl)adenosine
-
-
2-(cyclopentylsulfanyl)adenosine
-
-
2-(cyclopentylsulfanyl)adenosine
-
-
2-(pentyloxy)adenosine
-
-
2-(pentyloxy)adenosine
-
-
2-(pentylsulfanyl)adenosine
-
-
2-(pentylsulfanyl)adenosine
-
-
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
-
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
-
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
-
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
-
2-amino-6,7-dimethoxyquinoline-3-carboxamide
-
2-amino-6,7-dimethoxyquinoline-3-carboxamide
-
-
2-amino-6,7-dimethoxyquinoline-3-carboxamide
-
-
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
-
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
-
-
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
-
-
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
-
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
-
2-iodo-AMP
-
-
2-iodo-NAD+
-
-
2-methylthio-ATP
potent inhibitor
2-phenyl-NAD+
-
-
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
-
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
-
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
-
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
-
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
-
2-[(decahydronaphthalen-2-yl)oxy]adenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
-
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
-
-
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
-
-
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
-
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
-
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
-
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
-
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
-
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
-
5'-deoxy-2-(pentyloxy)adenosine
-
-
5'-deoxy-2-(pentyloxy)adenosine
-
-
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
-
-
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
-
-
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
-
-
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
-
-
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
-
-
5'-deoxy-2-phenoxyadenosine
-
-
5'-deoxy-2-phenoxyadenosine
-
-
5'-deoxy-2-phenoxyadenosine
-
-
5'-deoxy-2-phenoxyadenosine
-
-
5'-deoxy-2-phenoxyadenosine
-
-
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
-
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
-
-
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
-
-
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
-
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
-
-
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
-
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
-
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
-
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
-
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
-
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
-
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
-
-
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
-
-
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
-
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
-
-
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
-
-
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
-
-
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
-
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
-
-
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
-
-
8-hydroxyquinoline-2-carboxylic acid
-
8-hydroxyquinoline-2-carboxylic acid
-
-
8-hydroxyquinoline-2-carboxylic acid
-
-
8-methoxy-2,3-dimethylquinoxalin-5-ol
-
8-methoxy-2,3-dimethylquinoxalin-5-ol
-
-
8-methoxy-2,3-dimethylquinoxalin-5-ol
-
-
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
-
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
-
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
-
-
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
-
-
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
-
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
-
-
AMP
-
inhibits adenylation reaction
ATP
-
1 mM
ATP
-
inhibits adenylation reaction
Chloroquine
-
effective inhibitor
doxorubicin
-
doxorubicin inhibits the ATP-dependent DNA ligase of bacteriophage T4 and the Escherichia coli NAD+-dependent ligase with a similar potency
doxorubicin
-
IC50: 0.0033 mM
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
-
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
-
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
-
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
-
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
-
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
-
hydroxychloroquine
-
specific inhibitor of the Escherichia coli enzyme
Quinacrine
-
powerful inhibitor, exhibits good inhibition at nanomolar concentrations
additional information
-
not inhibited by cinchonidine, quinine, and N,N'-bis[4chloroquinolin-8-yl]succinamide
-
additional information
-
not inhibited by trimethoprim
-
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0.085
(29S,34S,36R,37R)-1,1'-(1,3-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-hydroxypropyl)urea)
Mycobacterium tuberculosis
-
0.225
(29S,34S,36R,37R)-1,1'-(1,4-phenylene)bis(3-((S)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)-3-ethoxy-3-oxopropyl)urea)
Mycobacterium tuberculosis
-
0.000507 - 0.13
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
0.0001 - 0.01
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
0.00021 - 0.03
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
0.016 - 0.12
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
0.0015
(3aR,5R,6R,6aS)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-6-hydroxy-2-sulfanyltetrahydro-2H-2lambda-5-furo[2,3-d][1,3,2]dioxaphosphol-2-one
Escherichia coli
-
pH and temperature not specified in the publication
0.0000488
(3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.000051
(3S)-3-[4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]-4-hydroxycyclopentanecarboxylic acid
Escherichia coli
-
pH and temperature not specified in the publication
0.0462
(3S,3'R)-3,3'-(propane-1,3-diyldiimino)bis[3-[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]propan-1-ol]
Mycobacterium tuberculosis
-
0.00002
(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)acetonitrile
Escherichia coli
-
pH and temperature not specified in the publication
0.005
(8R,10R)-10-((4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-hydroxymethoxymethyl-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione
Mycobacterium tuberculosis
IC50: 0.005 mM
0.12
(Rp)-3',5'-cyclic adenosine monophosphothiolate
Escherichia coli
-
37°C, pH 7.4, DNA ligation
0.0058
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.354
1,6-bis(3,4-dimethoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.0029
1,6-bis(4-bromophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.0023
1,6-bis(4-fluorophenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.0177
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).2(3)]nonan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.015
1,6-bis(4-methoxyphenyl)dispiro[2.1.2(5).3(3)]decan-4-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.054
1,N6-etheno-NAD+
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.0135
12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole
Mycobacterium tuberculosis
-
0.0009
2,4-diamino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carbonitrile
Escherichia coli
-
-
0.000021 - 0.002
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
0.00002 - 0.00224
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
0.00102
2,7-bis[(3,4,5-trimethoxyphenyl)methyl]cycloheptan-1-one
Wolbachia sp. subsp. Brugia malayi
at pH 8.0 and 20°C
0.00013 - 0.00017
2-(butylsulfanyl)-5'-deoxyadenosine
0.081
2-(butylsulfanyl)-5-hydroadenosine
Haemophilus influenzae
pH and temperature not specified in the publication
0.00007 - 0.00127
2-(butylsulfanyl)adenosine
0.00002 - 0.00016
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
0.00001 - 0.00013
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
0.00007 - 0.00009
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
0.00001 - 0.00013
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
0.00012
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
0.000019 - 0.00037
2-(cyclopentyloxy)-5'-deoxyadenosine
0.00007 - 0.00009
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
0.00015 - 0.00051
2-(cyclopentyloxy)adenosine
0.00038 - 0.00044
2-(cyclopentylsulfanyl)adenosine
0.00015 - 0.00043
2-(pentyloxy)adenosine
0.00038 - 0.00044
2-(pentylsulfanyl)adenosine
0.01
2-amino-5-(2-hydroxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.01
2-amino-5-(2-methoxyethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0025
2-amino-5-(aminomethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0005
2-amino-5-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0001
2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
Escherichia coli
-
-
0.0025
2-amino-5-phenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.001
2-amino-5-[(3R)-3-aminopyrrolidin-1-yl]-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.005 - 0.2
2-amino-6,7-dimethoxyquinoline-3-carboxamide
0.001
2-amino-6-(2-phenylethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
value above, pH and temperature not specified in the publication
0.0005
2-amino-6-(hydroxymethyl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0008
2-amino-6-(propan-2-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0008
2-amino-6-benzyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0005
2-amino-6-benzyl-7-chloro-5-methyl-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0005
2-amino-6-bromo-5-(3-hydroxyazetidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0007
2-amino-6-bromo-5-(4-hydroxypiperidin-1-yl)-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0007
2-amino-6-bromo-5-[(2-hydroxyethyl)(methyl)amino]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0007
2-amino-6-bromo-5-[(3R)-3-hydroxypyrrolidin-1-yl]-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0003
2-amino-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0005
2-amino-6-bromo-7-cyclopentyl-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0003
2-amino-6-bromo-7-tert-butyl-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.008
2-amino-6-chloro-5-ethyl-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0025
2-amino-6-cyclopentyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0004
2-amino-6-cyclopropyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0004
2-amino-6-ethenyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0006
2-amino-6-ethyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0005
2-amino-6-methyl-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.00008
2-amino-7,8-difluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
Escherichia coli
-
-
0.0005
2-amino-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.0008
2-amino-7-chloro-5-methyl-6-(prop-2-en-1-yl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.001
2-amino-7-chloro-5-methyl-6-(pyridin-4-ylmethyl)-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
pH and temperature not specified in the publication
0.00004
2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
Escherichia coli
-
-
0.005
2-amino-7-[2-(benzyloxy)propan-2-yl]-6-bromo-1,8-naphthyridine-3-carboxamide
Escherichia coli
-
value above, pH and temperature not specified in the publication
0.00001 - 0.000107
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
0.15 - 0.2
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
0.13 - 0.2
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
0.2
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
0.0041
2-methylthio ADP
Escherichia coli
-
37°C, pH 7.4, DNA ligation
0.0011
2-methylthio ATP
Escherichia coli
-
37°C, pH 7.4, DNA ligation
0.0005
2-methylthio-ATP
Enterococcus faecalis
-
0.00006 - 0.00013
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
0.00004 - 0.00026
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
0.00008 - 0.0004
2-[(decahydronaphthalen-2-yl)oxy]adenosine
0.00004
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
0.00008 - 0.00011
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
0.00002 - 0.00003
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
0.26
3,3'-(decane-1,10-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propan-1-ol)
Mycobacterium tuberculosis
-
0.0462
3,3'-(propane-1,3-diylbis(azanediyl))bis(3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[2,3-d][1,3]dioxol-5-yl)propan-1-ol)
Mycobacterium tuberculosis
-
0.004
3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-(3-phenoxymethyl-thioureido)-propionic acid ethyl ester
Mycobacterium tuberculosis
IC50: 0.004 mM
0.0277
3-((R)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-3-[3-(3-{3-[1-((S)-6-benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-ethoxycarbonyl-ethyl]-ureido}-phenyl)-ureido]-propionic acid ethyl ester
Mycobacterium tuberculosis
IC50: 0.0277 mM
0.000036
3-(4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)propanenitrile
Escherichia coli
-
pH and temperature not specified in the publication
0.138 - 0.2
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
0.073
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-phenyl-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.000019
4-([4-amino-2-[(2-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)benzoic acid
Escherichia coli
-
pH and temperature not specified in the publication
0.00009
4-amino-2-(1,4-dioxaspiro[4.5]dec-8-yloxy)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.029 - 0.2
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.00195
4-amino-2-(2-fluoroethoxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.01
4-amino-2-(cyclopentylamino)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.0051
4-amino-2-(cyclopentyloxy)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.0035
4-amino-2-(cyclopentylsulfanyl)-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000063
4-amino-2-(cyclopentylsulfanyl)-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.003 - 0.2
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.021 - 0.16
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
0.2
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
0.00031
4-amino-2-[(1,3-difluoropropan-2-yl)oxy]-8-(2-hydroxyethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00017
4-amino-2-[(2,4-dimethylcyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000036
4-amino-2-[(2-methylcyclohexyl)oxy]-8-(1H-pyrazol-4-ylmethyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000028
4-amino-2-[(2-methylcyclohexyl)oxy]-8-[(1R,5R)-7-oxo-6-oxabicyclo[3.2.1]oct-4-yl]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000041
4-amino-2-[(4-chlorocyclohexyl)oxy]-8-[(1R)-2-hydroxycyclopentyl]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.1 - 0.2
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.036 - 0.2
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
0.14 - 0.2
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.025
4-amino-6-(1H-benzimidazol-2-yl)pyridazin-3(2H)-one
Escherichia coli
-
value above, pH and temperature not specified in the publication
0.000079
4-amino-8-(2,3-dihydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000057
4-amino-8-(2-hydroxyethyl)-2-(2-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00042
4-amino-8-(2-hydroxyethyl)-2-(4-methylcyclohexyl)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00106
4-amino-8-(2-hydroxyethyl)-2-(propan-2-yloxy)pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000028
4-amino-8-(3-fluoro-2-hydroxypropyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00002
4-amino-8-(cyclopent-3-en-1-ylmethyl)-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00035
4-amino-8-[(1R)-2-hydroxycyclopentyl]-2-[[4-(trifluoromethyl)cyclohexyl]oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000225
4-amino-8-[(1S)-2,3-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000039
4-amino-8-[(1S,2S)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00011
4-amino-8-[(2R)-2-hydroxycyclohexyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00019
4-amino-8-[(2R)-2-hydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000076
4-amino-8-[(2S,5S)-2,5-dihydroxycyclopentyl]-2-[(4-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000068
4-amino-8-[(3,4-dihydroxycyclopentyl)methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.00004
4-amino-8-[[(2R)-2-hydroxycyclopentyl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.000038
4-amino-8-[[(4S)-4-hydroxytetrahydrofuran-3-yl]methyl]-2-[(2-methylcyclohexyl)oxy]pyrido[2,3-d]pyrimidin-5(8H)-one
Escherichia coli
-
pH and temperature not specified in the publication
0.075 - 0.2
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
0.0094 - 0.2
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
0.052 - 0.2
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
0.025 - 0.2
4-aminothieno[3,2-c]pyridine-7-carboxamide
0.00008 - 0.00012
5'-deoxy-2-(pentyloxy)adenosine
0.000038 - 0.00018
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
0.00014 - 0.00267
5'-deoxy-2-phenoxyadenosine
0.00004 - 0.00018
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
0.00001 - 0.00032
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
0.0002 - 0.0017
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
0.00012
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
0.00087 - 0.00091
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
0.00001 - 0.012
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
0.00037 - 0.0004
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
0.0011 - 0.01
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0037 - 0.01
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00034 - 0.01
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00046 - 0.013
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00059 - 0.01
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00047 - 0.01
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00053 - 0.01
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0015 - 0.01
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00072 - 0.01
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002 - 0.00049
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000021 - 0.00031
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012 - 0.0014
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000031 - 0.00078
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000026 - 0.00165
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000044 - 0.00065
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002 - 0.000068
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000013 - 0.00064
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012 - 0.0018
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0003 - 0.2
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000032 - 0.00072
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00042 - 0.0066
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00011 - 0.00133
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00016 - 0.00275
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00055 - 0.01398
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000044 - 0.00052
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00031 - 0.00219
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000015 - 0.0021
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000067 - 0.0017
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00015 - 0.0018
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000043 - 0.0011
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000007 - 0.0005
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002 - 0.00079
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012 - 0.2
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00015 - 0.2
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000034 - 0.00062
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
0.00049
5-([4-amino-2-[(4-methylcyclohexyl)oxy]-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl]methyl)thiophene-2-carboxylic acid
Escherichia coli
-
pH and temperature not specified in the publication
0.003 - 0.094
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
0.00965
5-[[[(4-chlorophenyl)amino]carbonyl](phenylmethyl)amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-3-O-(phenylmethyl)-alpha-L-gluco-heptofuranuronic acid ethyl ester
Mycobacterium tuberculosis
IC50: 0.00965 mM
0.018 - 0.767
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
0.00003 - 0.000077
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
0.0001 - 0.00024
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
0.025
7-methoxy-6-methylpteridine-2,4-diamine
Escherichia coli
-
pH and temperature not specified in the publication
0.0028 - 0.5
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
0.425 - 0.61
8-hydroxyquinoline-2-carboxylic acid
0.32 - 1.31
8-methoxy-2,3-dimethylquinoxalin-5-ol
0.00004
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.00002 - 0.00003
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
0.00008 - 0.00011
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
0.046 - 0.053
Chloroquine
0.0014
Chloroquine diphosphate
Staphylococcus aureus
-
IC50: 0.0014 mM
0.0033
doxorubicin
Staphylococcus aureus
-
IC50: 0.0033 mM
0.00002 - 0.01
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
0.00039 - 0.2
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
0.00965
ethyl 3-(1-benzyl-3-(4-chlorophenyl)ureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate
Mycobacterium tuberculosis
-
0.004
ethyl 3-(3-benzoylthioureido)-3-(6-(benzyloxy)-2,2-dimethyl-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)propanoate
Mycobacterium tuberculosis
-
0.0089 - 0.2
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
0.004
ethyl-3-O-benzyl-5,6-dideoxy-1,2-O-(1-methylethylidene)-5-[[(phenylcarbonyl)carbamoyl]amino]-alpha-L-xylo-heptofuranuronate
Mycobacterium tuberculosis
-
0.00965
ethyl-3-O-benzyl-5-[benzyl[(4-chlorophenyl)carbamoyl]amino]-5,6-dideoxy-1,2-O-(1-methylethylidene)-alpha-L-xylo-heptofuranuronate
Mycobacterium tuberculosis
-
0.063
hydroxychloroquine
Escherichia coli
-
-
0.0018
N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-6-yl]sebacamide
Escherichia coli
-
-
0.009
N,N'-bis[4-((4-(diethylamino)-1-methylbutyl)amino)-quinoline-8-yl]adipamide
Escherichia coli
-
-
0.0114
N,N'-bis[[(3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl]dodecane-1,12-diamine
Mycobacterium tuberculosis
-
0.046
N1-(7-chloro-[4]quinolyl)-N4,N4-bis-(2-hydroxy-ethyl)-1-methyl-butanediyldiamine
Mycobacterium tuberculosis
IC50: 0.046 mM
0.046
N4-(7-chloro-7,8-dihydroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine
Mycobacterium tuberculosis
-
0.046
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine
Mycobacterium tuberculosis
-
0.0006
pyridochromanone
Mycobacterium tuberculosis
-
IC50: 0.0006 mM
0.0015
Quinacrine
Escherichia coli
-
-
0.0015
Sp-3',5'-cyclic adenosine monophosphothiolate
Escherichia coli
-
37°C, pH 7.4, DNA ligation
0.005
tert-butyl 3-(7-amino-3-bromo-6-carbamoyl-1,8-naphthyridin-2-yl)azetidine-1-carboxylate
Escherichia coli
-
value above, pH and temperature not specified in the publication
0.000507
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.13
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-4,5-dihydro-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0001
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Streptococcus pneumoniae
-
wild-type, 25°C, pH 7.5
0.0002
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Streptococcus pneumoniae
-
wild-type, 25°C, pH 7.5
0.01
(2R,3R,4S,5R)-2-[6-amino-2-(butylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Streptococcus pneumoniae
-
mutant L75F, 25°C, pH 7.5
0.00021
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00043
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00051
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.03
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Streptococcus pneumoniae
-
mutant L75F, 25°C, pH 7.5
0.016
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.12
(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl dihydrogen phosphate
Escherichia coli
-
pH and temperature not specified in the publication
0.000021
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000035
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.002
2,4-diamino-7-tert-butyl-1,8-naphthyridine-3-carbonitrile
Haemophilus influenzae
pH and temperature not specified in the publication
0.00002
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00004
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00023
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
Escherichia coli
-
at pH 7.4 and 20°C
0.00224
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00013
2-(butylsulfanyl)-5'-deoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00017
2-(butylsulfanyl)-5'-deoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00007
2-(butylsulfanyl)adenosine
Mycoplasma pneumoniae
-
pH and temperature not specified in the publication
0.000075
2-(butylsulfanyl)adenosine
Streptococcus pneumoniae
-
pH 7.5, 22°C
0.00008
2-(butylsulfanyl)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000081
2-(butylsulfanyl)adenosine
Mycoplasma pneumoniae
-
pH 7.5, 22°C
0.000136
2-(butylsulfanyl)adenosine
Haemophilus influenzae
-
pH 7.5, 22°C
0.00014
2-(butylsulfanyl)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000507
2-(butylsulfanyl)adenosine
Staphylococcus aureus
-
pH 7.5, 22°C
0.00051
2-(butylsulfanyl)adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00127
2-(butylsulfanyl)adenosine
Escherichia coli
-
pH 7.5, 22°C
0.00127
2-(butylsulfanyl)adenosine
Escherichia coli
-
pH and temperature not specified in the publication
0.00002
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Mycoplasma pneumoniae
-
pH and temperature not specified in the publication
0.000021
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Streptococcus pneumoniae
-
pH 7.5, 22°C
0.00005
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000052
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Haemophilus influenzae
-
pH 7.5, 22°C
0.00006
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000063
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Mycoplasma pneumoniae
-
pH 7.5, 22°C
0.000076
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Staphylococcus aureus
-
pH 7.5, 22°C
0.00008
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.000158
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Escherichia coli
-
pH 7.5, 22°C
0.00016
2-(cyclobutylmethoxy)-5'-deoxy-5'-fluoroadenosine
Escherichia coli
-
pH and temperature not specified in the publication
0.00001
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00013
2-(cyclopentyloxy)-3',5'-dideoxy-3'-[(3,5-dichlorophenyl)methyl]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00007
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00009
2-(cyclopentyloxy)-3',5'-dideoxy-5'-fluoro-3'-(1H-triaziren-1-yl)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00001
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00013
2-(cyclopentyloxy)-5'-deoxy-3'-O-(3,4-dichlorobenzyl)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00012
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00012
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000019
2-(cyclopentyloxy)-5'-deoxyadenosine
Streptococcus pneumoniae
-
pH 7.5, 22°C
0.00002
2-(cyclopentyloxy)-5'-deoxyadenosine
Mycoplasma pneumoniae
-
pH and temperature not specified in the publication
0.000076
2-(cyclopentyloxy)-5'-deoxyadenosine
Haemophilus influenzae
-
pH 7.5, 22°C
0.00008
2-(cyclopentyloxy)-5'-deoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00011
2-(cyclopentyloxy)-5'-deoxyadenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.000112
2-(cyclopentyloxy)-5'-deoxyadenosine
Staphylococcus aureus
-
pH 7.5, 22°C
0.000117
2-(cyclopentyloxy)-5'-deoxyadenosine
Mycoplasma pneumoniae
-
pH 7.5, 22°C
0.00012
2-(cyclopentyloxy)-5'-deoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00037
2-(cyclopentyloxy)-5'-deoxyadenosine
Escherichia coli
-
pH 7.5, 22°C
0.00037
2-(cyclopentyloxy)-5'-deoxyadenosine
Escherichia coli
-
pH and temperature not specified in the publication
0.00007
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00009
2-(cyclopentyloxy)-9-[3,5-dideoxy-5-fluoro-3-(2l5-triaz-1-en-2-yn-1-yl)-b-D-xylofuranosyl]-9H-purin-6-amine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00015
2-(cyclopentyloxy)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00043
2-(cyclopentyloxy)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00051
2-(cyclopentyloxy)adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00038
2-(cyclopentylsulfanyl)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00044
2-(cyclopentylsulfanyl)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00015
2-(pentyloxy)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00043
2-(pentyloxy)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00038
2-(pentylsulfanyl)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00044
2-(pentylsulfanyl)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.005
2-amino-6,7-dimethoxyquinoline-3-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.076
2-amino-6,7-dimethoxyquinoline-3-carboxamide
Haemophilus influenzae
pH and temperature not specified in the publication
0.2
2-amino-6,7-dimethoxyquinoline-3-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00001
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
Haemophilus influenzae
pH and temperature not specified in the publication
0.000067
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000107
2-amino[1,4]benzodioxino[2,3-b]pyridine-3-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.15
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.16
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.16
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
value above, pH and temperature not specified in the publication
0.13
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.15
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.18
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.2
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.2
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
value above, pH and temperature not specified in the publication
0.2
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.2
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
value above, pH and temperature not specified in the publication
0.00006
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00013
2-[(bicyclo[3.1.0]hexan-3-yl)oxy]-5'-deoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00004
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00026
2-[(decahydronaphthalen-2-yl)oxy]-5'-deoxyadenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00008
2-[(decahydronaphthalen-2-yl)oxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0004
2-[(decahydronaphthalen-2-yl)oxy]adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00004
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00004
3'-chloro-2-(cyclopentyloxy)-3',5'-dideoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00008
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00011
3'-chloro-2-(cyclopentyloxy)-3'-deoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00002
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00003
3'-chloro-3',5'-dideoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.138
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
Escherichia coli
-
pH and temperature not specified in the publication
0.2
3-[[[[(2R,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]oxy](hydroxy)phosphoryl]carbamoyl]-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridin-1-ium
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.029
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.036
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.1
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.003
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0071
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0081
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.021
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.048
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.077
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.16
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.2
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
value above, pH and temperature not specified in the publication
0.2
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.1
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
value above, pH and temperature not specified in the publication
0.2
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.036
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.039
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.13
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.14
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
value above, pH and temperature not specified in the publication
0.2
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
value above, pH and temperature not specified in the publication
0.2
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.075
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.14
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.0094
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.015
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.034
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.052
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.069
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.025
4-aminothieno[3,2-c]pyridine-7-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-7-carboxamide
Staphylococcus aureus
-
value above, pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-7-carboxamide
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
0.2
4-aminothieno[3,2-c]pyridine-7-carboxamide
Enterococcus faecalis
-
value above, pH and temperature not specified in the publication
0.00008
5'-deoxy-2-(pentyloxy)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00012
5'-deoxy-2-(pentyloxy)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000038
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
Haemophilus influenzae
-
pH 7.5, 22°C
0.00006
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
Mycoplasma pneumoniae
-
pH 7.5, 22°C
0.000062
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
Streptococcus pneumoniae
-
pH 7.5, 22°C
0.000082
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
Staphylococcus aureus
-
pH 7.5, 22°C
0.00018
5'-deoxy-2-(spiro[2.2]pent-1-ylmethoxy)adenosine
Escherichia coli
-
pH 7.5, 22°C
0.00014
5'-deoxy-2-phenoxyadenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00267
5'-deoxy-2-phenoxyadenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00004
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00006
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00006
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Mycoplasma pneumoniae
-
pH and temperature not specified in the publication
0.00008
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00018
5'-deoxy-2-[(spiro[2.2]pentan-1-yl)methoxy]adenosine
Escherichia coli
-
pH and temperature not specified in the publication
0.00001
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Mycoplasma pneumoniae
-
pH and temperature not specified in the publication
0.00005
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00011
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00016
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00032
5'-deoxy-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Escherichia coli
-
pH and temperature not specified in the publication
0.0002
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0017
5'-deoxy-2-[(tricyclo[3.3.1.1~3,7~]decan-2-yl)methoxy]adenosine
Haemophilus influenzae
-
pH and temperature not specified in the publication
0.00012
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00012
5'-deoxy-5'-fluoro-2-(pentyloxy)adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00087
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00091
5'-deoxy-5'-fluoro-2-[(1,3-thiazol-2-yl)methoxy]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00001
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Streptococcus pneumoniae
-
IC50 less 0.00001 mM, pH 7.5, 22°C
0.000039
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Haemophilus influenzae
-
pH 7.5, 22°C
0.00004
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Streptococcus pneumoniae
-
wild-type, 25°C, pH 7.5
0.000106
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Staphylococcus aureus
-
pH 7.5, 22°C
0.000158
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Mycoplasma pneumoniae
-
pH 7.5, 22°C
0.00032
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Escherichia coli
-
pH 7.5, 22°C
0.012
5'-deoxy-5'-fluoro-2-[(trans-4-methylcyclohexyl)oxy]adenosine
Streptococcus pneumoniae
-
mutant L75F, 25°C, pH 7.5
0.00037
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0004
5'-deoxy-5'-fluoro-2-[[1-(hydroxymethyl)cyclopropyl]methoxy]adenosine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0011
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0018
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.0037
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.005
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00034
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00041
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00046
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00069
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.013
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00059
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00081
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00047
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00052
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00053
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00067
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.0015
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00072
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00097
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00002
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000057
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00049
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000021
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000036
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00031
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00012
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00027
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0014
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000031
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.0001
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00078
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000026
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00011
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00165
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000044
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00026
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00065
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00002
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000068
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.000013
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000042
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00064
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00012
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00035
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0018
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.0003
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.0016
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.2
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000032
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000059
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00072
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00042
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00101
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0066
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00011
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00043
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00133
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00016
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.0004
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00275
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00055
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00144
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01398
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000044
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00016
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00052
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00031
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00074
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00219
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000015
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00012
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0021
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000067
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00022
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0017
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00015
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00047
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0018
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000043
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00011
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0011
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000007
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000084
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.0005
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00002
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00017
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00079
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00012
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00022
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.2
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00015
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.0005
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00209
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.013
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.044
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.2
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000034
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00055
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.00062
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.003
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.061
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
Haemophilus influenzae
pH and temperature not specified in the publication
0.094
5-amino-3-(furan-2-yl)-1H-1,2,4-triazole-1-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.018
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.025
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.767
6-methyl-5-[(propan-2-yl)oxy][1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Haemophilus influenzae
pH and temperature not specified in the publication
0.00003
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.000037
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.000077
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.000077
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
Escherichia coli
-
at pH 7.4 and 20°C
0.0001
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0001
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
Haemophilus influenzae
pH and temperature not specified in the publication
0.00024
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0028
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.028
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.5
8-hydroxy-2-methyl-3,4-dihydroquinoline-6-carboxamide
Haemophilus influenzae
pH and temperature not specified in the publication
0.425
8-hydroxyquinoline-2-carboxylic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.447
8-hydroxyquinoline-2-carboxylic acid
Haemophilus influenzae
pH and temperature not specified in the publication
0.61
8-hydroxyquinoline-2-carboxylic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.32
8-methoxy-2,3-dimethylquinoxalin-5-ol
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
1.31
8-methoxy-2,3-dimethylquinoxalin-5-ol
Haemophilus influenzae
pH and temperature not specified in the publication
0.00004
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00004
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00002
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00003
9-(3-chloro-3,5-dideoxy-beta-D-xylofuranosyl)-2-(spiro[2.2]pent-1-ylmethoxy)-9H-purin-6-amine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00008
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00011
9-(3-chloro-3-deoxy-beta-D-xylofuranosyl)-2-(cyclopentyloxy)-9H-purin-6-amine
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.046
Chloroquine
Mycobacterium tuberculosis
chloroquine inhibits the enzyme with an IC50 of about 0.046 mM
0.053
Chloroquine
Escherichia coli
-
-
0.00002
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.00053
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.01
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.00039
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
Streptococcus pneumoniae
-
at pH 7.4 and 20°C
0.2
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
Staphylococcus aureus
-
at pH 7.4 and 20°C
0.2
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
Haemophilus influenzae
-
at pH 7.4 and 20°C
0.0089
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0094
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.074
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
Enterococcus faecalis
-
pH and temperature not specified in the publication
0.2
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
Haemophilus influenzae
-
value above, pH and temperature not specified in the publication
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D117A
-
no nick-ligation activity
D27A
-
no effect on activity
D48A
-
reduced adenylate-transfer activity, no effect on DNA-ligation with preadenylated nick
D52A
-
reduced adenylate-transfer activity, no effect on DNA-ligation with preadenylated nick
DEL1-70
-
inactive in overall ligation reaction, fully functional with preadenylated nick
DEL216-532
-
inactive in overall ligation reaction, formation of adenylate-ligase intermediate not affected
K115A
-
no nick-ligation activity
Y39A
-
reduced adenylate-transfer activity, no effect on DNA-ligation with preadenylated nick
Y40A
-
reduced adenylate-transfer activity, no effect on DNA-ligation with preadenylated nick
Y51A
-
adenylate-transfer activity abolished, no effect on DNA-ligation with preadenylated nick
DELTA1-525
-
no DNA-binding
DELTA1-90
-
very low self adenylation activity, active in DNA-ligation, reduced DNA-binding
DELTA1-90,363-719
-
no self adenylation
DELTA1-90,487-719
-
very low self adenylation activity
DELTA363-719
-
full self adenylation activity
DELTA517-719
-
full self adenylation activity
DELTA636-719
-
active in DNA-ligation
K128A
-
mutant enzyme shows no ligation activity
C408A
-
inactive, unable to complement DNA-ligase-deficient yeast
C411A
-
inactive, unable to complement DNA-ligase-deficient yeast
C426A
-
no effect in vivo, 7% of wild type activity
C432A
-
inactive, unable to complement DNA-ligase-deficient yeast
D117A
-
inactive in nick-joining, unable to complement DNA-ligase-deficient yeast
D117E
-
3% of ligase activity of wild-type enzyme, lethal mutation
D117N
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
D138A
-
37% of ligase activity of wild-type enzyme
D283A
-
57% of ligase activity of wild-type enzyme
D285E
-
4% of ligase activity of wild-type enzyme, lethal mutation
D285N
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
D32A
-
traces of nick joining activity
D32E
-
traces of nick joining activity
D32N
-
9% of nick joining activity, strongly reduced self-adenylation
D36A
-
traces of nick joining activity
D36E
-
4% of nick joining activity, strongly reduced self-adenylation
D36N
-
12% of nick joining activity, strongly reduced self-adenylation
D450A
the helix-hairpin-helix domain mutant retains DNA relaxation function, concordant with the ability to effectively ligate nicks
D452A
mutant with 68% of wild type activity
DELTA1-592
-
fragment corresponding to BRCT domain binds to a wider range of substrates compared to full-length LigA
DELTA593-671
-
mutant lacking the BRCT domain, 3fold reduced in vitro ligation activity and reduced DNA binding
E10A
-
90% of nick joining activity
E113A
-
no effect in vivo, increased Km for NAD+, 40% of wild type activity
E143A
-
52% of ligase activity of wild-type enzyme
E173A
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
E173D
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
E173Q
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
E319A
-
no effect in vivo, 69% of wild type activity
G118A
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
G172A
-
36% of ligase activity of wild-type enzyme
G286A
-
14% of ligase activity of wild-type enzyme
G489A
the mutant retains 25% of wild type activity
G489D
mutant with 0.8% of wild type activity
G489V
mutant with 3.2% of wild type activity
G521A
the mutant is 50fold less active than wild type LigA
G521D
mutant with less than 0.1% of wild type function
G521V
mutant with less than 0.1% of wild type function
G553A
mutant with 38% of wild type activity
G553D
mutant with 2.6% of wild type activity
G553V
mutant with 0.9% of wild type activity
H23A
-
10% of nick joining activity
H23Y
-
88% of nick joining activity
I384A
the mutant is defective for nick sealing, retaining 4% of wild type activity
K115A
-
inactive in nick-joining, unable to complement DNA-ligase-deficient yeast
K115Q
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
K115R
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
K290A
-
13% of ligase activity of wild-type enzyme, lethal mutation
K314A [DV1]
-
accumulation of the DNA-adenylate intermediate, loss of function in vivo, strongly reduced activity
K314Q
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
K314R
-
5% of ligase activity of wild-type enzyme, lethal mutation
K627A
mutant with 40% of wild type activity
K634A/K635A
mutant with 44% of wild type activity
K648A
mutant with 37% of wild type activity
K651A
mutant with 35% of wild type activity
L119A
-
110% of ligase activity of wild-type enzyme
L15F
-
at 20°C mutant enzyme L15F has 20fold lower ligation activity in vitro, and its activity is reduced at 42°C, resulting in 60fold lower ligation activity than wild-type LigA
N198A
-
26% of ligase activity of wild-type enzyme
N355A
mutant with 30% of wild type activity
Q318A
-
no effect in vivo, 80% of wild type activity
Q330A
the mutation has no apparent effect on nick sealing acivity
Q386A
mutant with 30% of wild type activity
R200A
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
R200K
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
R200Q
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
R208A
-
2% of ligase activity of wild-type enzyme, lethal mutation
R208K
-
1.2% of ligase activity of wild-type enzyme, lethal mutation
R208Q
-
less than 0.1% of ligase activity of wild-type enzyme, lethal mutation
R277K
-
5.6% of ligase activity of wild-type enzyme, themperature-sensitive mutation, rate of isolated sealing step is 4% of the activity of wild-type enzyme
R277Q
-
1.8% of ligase activity of wild-type enzyme, lethal mutation, rate of isolated sealing step is 10% of the activity of wild-type enzyme
R333A
the oligonucleotide-binding domain mutation strongly suppresses DNA relaxation
R379A
the oligonucleotide-binding domain mutation strongly suppresses DNA relaxation
R487A
mutant with 6% of wild type activity
R510A
the helix-hairpin-helix domain mutant retains DNA relaxation function, concordant with the ability to effectively ligate nicks
R614A
mutant with 14% of wild type activity
V288A
-
74% of ligase activity of wild-type enzyme
V383A
the mutant is defective for nick sealing, retaining 4% of wild type activity
Y225A
-
no effect in vivo, increased Km for NAD+, 25% of wild type activity
Y22A
-
traces of nick joining activity, strongly reduced self-adenylation
Y22S
-
9% of nick joining activity
Y35A
-
2% of nick joining activity, strongly reduced self-adenylation
Y35S
-
23% of nick joining activity
L15F
-
at 20°C mutant enzyme L15F has 20fold lower ligation activity in vitro, and its activity is reduced at 42°C, resulting in 60fold lower ligation activity than wild-type LigA
-
DELTA1-396
-
no self adenylation activity, DNA-binding not affected
DELTA319-670
-
full self adenylation activity but strongly reduced DNA-binding and ligation activity
K114A
-
prevention of partial adenylation of the enzyme
D141A
-
adenylation-defective mutant
K139A
-
adenylation-defective mutant
D46A
-
mutant protein displayes only trace sealing activity
D50A
-
nick sealing activity is 6% of wild-type activity
K113A
-
mutant protein is inert
Y36A
-
mutant protein displayes only trace sealing activity
Y49A
-
nick sealing activity is 6% of wild-type activity
DELTA1-390
-
DNA binding, but no self adenylation activity
DELTA316-667
-
active in self adenylation but unable to bind DNA
L75F
-
L75F mutant is as catalytically efficient as wild-type, athough the NAD Km is slightly elevated compared to wild-type, it is still likely well below the concentration of NAD in the bacterium. IC50 for inhibitors elevated compared to wild-type
DELTA582-667
-
lower thermal stability than wild-type enzyme
D286E
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
G287A
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme. The G287A mutation has a major effect on the second step
K291R
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
V289I
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
A644I
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
E654A
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
G617I
-
mutation in BRCT domain, mutant enzyme does not shows any detectable ligation with nicked substrate in excess
G634I
-
mutation in BRCT domain, ligation activity is about 15% of the activity with wild-type enzyme with nicked substrate in excess
G638I
-
mutation in BRCT domain, ligation activity is 30-40% lower than that with wild-type enzyme with nicked substrate in excess
K619R
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
K640R
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
L647A
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
R606A
-
mutation in BRCT domain, ligation activity is 30-40% lower than that with wild-type enzyme with nicked substrate in excess
S623A
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
T599A
-
mutation in BRCT domain, ligation activity is 30-40% lower than that with wild-type enzyme with nicked substrate in excess
V624A
-
mutation in BRCT domain, comparable ligation activity with wild-type enzyme with nicked substrate in excess
D286E
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
-
G287A
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme. The G287A mutation has a major effect on the second step
-
K291R
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
-
V289I
-
mutant enzyme shows reduced reaction rate on both match and mismatch nicked substrates compared to wild-type enzyme
-
C412M
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C412T
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C412V
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C415A
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C415M
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C415T
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C415V
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C428T
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C433A
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C433M
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C433T
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
C433V
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120A
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120E
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120G
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120N
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120V
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D120Y
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
G339A
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
G339D
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
G339E
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K118H
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K118L
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K118P1(CCC)
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K118P2(CCG)
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K118R
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K2942(CTC)
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K294L1(CTG)
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K294P
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K294Q
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
K294R
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
R337E
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
R337K
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
R337Q
-
Site-directed mutants: K118R, K118H, K118L, K118P1(CCC), K118P2(CCG), D120E, D120N, D120Y, D120G, D120A, D120V, K294R, K294Q, K294L1(CTG), K2942(CTC), K294P, K294P, R337K, R337Q, R337E, G339A, G339D, G339E, C412A, C412V, C412T, C412M, C415A, C415V, C415T, C415M, C428A, C428T, C433A, C433V, C433T and C433M. Studies show that residue K118 plays an essential role in the adenylation step, residue D120 may facilitate the deadenylation step, residue G339 and C433 may be involved in formation of the phosphodiester bond
D551A
mutant with 120% of wild type activity
D551A
the helix-hairpin-helix domain mutant retains DNA relaxation function, concordant with the ability to effectively ligate nicks
DELTA1-38
-
inactive, unable to complement DNA-ligase-deficient yeast
DELTA1-38
-
nick joining activity abolished, no self adenylation, active with pre-adenylated nick
DELTA1-78
-
inactive, unable to complement DNA-ligase-deficient yeast
DELTA1-78
-
nick joining activity abolished, no self adenylation, active with pre-adenylated nick
E519A
mutant with 71% of wild type activity
E519A
the helix-hairpin-helix domain mutant retains DNA relaxation function, concordant with the ability to effectively ligate nicks
R277A
-
1.1% of ligase activity of wild-type enzyme, lethal mutation
R277A
-
rate of isolated sealing step is 20% of the activity of wild-type enzyme
additional information
-
truncated version of MimiLIG (C-DELTA79), composed of residues 1-557, but lacking the C-terminal 79 amino acids that comprise the BRCT domain shows reduced specific activity in nick joining by 75fold without affecting the ligase adenylylation step. The DELTA-RCT mutant of MimiLIG is impaired in sealing at a preadenylylated nick
additional information
deletion of just the BRCT domain from MtuLigA results in total loss of activity in in vitro assays
additional information
-
deletion of just the BRCT domain from MtuLigA results in total loss of activity in in vitro assays
additional information
-
deletion of just the BRCT domain from MtuLigA results in total loss of activity in in vitro assays
-
additional information
-
no ligation activity when both fragments are mixed together
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Engler, M.J.; Richardson, C.C.
DNA ligases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
15
3-29
1982
Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
brenda
Maunders, M.J.
DNA and RNA ligases (EC 6.5.1.1, EC 6.5.1.2, and EC 6.5.1.3)
Methods Mol. Biol.
16
213-230
1993
Bacillus subtilis, Escherichia coli, Thermus thermophilus, Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Takahashi, M.; Uchida, T.
Thermophilic HB8 DNA ligase: effects of polyethylene glycols and polyamines on blunt-end ligation of DNA
J. Biochem.
100
123-131
1986
Thermus thermophilus
brenda
Hayashi, K.; Nakazawa, M.; Ishizaki, Y.; Hiraoka, N.; Obayashi, A.
Stimulation of intermolecular ligation with E. coli DNA ligase by high concentrations of monovalent cations in polyethylene glycol solutions
Nucleic Acids Res.
13
7979-7992
1985
Escherichia coli
brenda
Takahashi, M.; Yamaguchi, E.; Uchida, T.
Thermophilic DNA ligase. Purification and properties of the enzyme from Thermus thermophilus HB8
J. Biol. Chem.
259
10041-10047
1984
Thermus thermophilus
brenda
Zimmerman, S.B.; Pheiffer, B.H.
Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli
Proc. Natl. Acad. Sci. USA
80
5852-5856
1983
Escherichia coli
brenda
Higgins, N.P.; Cozzarelli, N.R.
DNA-joining enzymes: A review
Methods Enzymol.
68
50-71
1979
Escherichia coli
brenda
Shibata, T.; Hayase, E.; Ando, T.
Simultaneous preparation of a DNA ligase and restriction endonucleases from Bacillus amyloliquefaciens
Agric. Biol. Chem.
42
1613-1615
1978
Bacillus amyloliquefaciens
-
brenda
Panasenko, S.M.; Alazard, R.J.; Lehman, I.R.
A simple, three-step procedure for the large scale purification of DNA ligase from a hybrid lysogen constructed in vitro
J. Biol. Chem.
253
4590-4592
1978
Escherichia coli
brenda
Modrich, P.; Anraku, Y.; Lehman, I.R.
Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogenous enzyme from Escherichia coli
J. Biol. Chem.
248
7475-7501
1973
Escherichia coli
-
brenda
Nozaki, T.; Masutani, M.; Noda, T.; Saito, D.; Sugiyama, T.; Takato, T.; Wakabayashi, K.; Nakagama, H.; Sugimura, T.
Helicobacter pylori extracts exhibit nicotinamide adenine dinucleotide-derived adenylation but not mono(adenosine 5'-diphosphate-ribosyl)ation of DNA ligase
Jpn. J. Cancer Res.
88
921-924
1997
Helicobacter pylori
brenda
Luo, J.; Barany, F.
Identification of essential residues in Thermus thermophilus DNA ligase
Nucleic Acids Res.
24
3079-3085
1996
Thermus thermophilus
brenda
Thorbjarnardottir, S.H.; Jonsson, Z.O.; Andresson, O.S.; Kristjansson, J.K.; Eggertsson, G.; Palsdottir, A.
Cloning sequence analysis of the DNA ligase-encoding gene of Rhodothermus marinus, and overproduction, purification and characterization of two thermophilic DNA ligase
Gene
161
1-6
1995
Thermus thermophilus, Thermus scotoductus, Rhodothermus marinus (P49421), Rhodothermus marinus
brenda
Jonsson, Z.O.; Thorbjarnardottir, S.H.; Eggertsson, G.; Palsdottir, A.
Sequence of the DNA ligase-encoding gene from thermus scotoductus and conserved motifs in DNA ligases
Gene
151
177-180
1994
Thermus scotoductus
brenda
Lee, J.Y.; Kim, H.K.; Chang, C.; Eom, S.H.; Hwang, K.Y.; Cho, Y.; Yu, Y.G.; Ryu, S.E.; Kwon, S.T.; Suh, S.W.
Crystallization and preliminary x-ray crystallographic analysis of NAD+-dependent DNA ligase from Thermus filiformis
Acta Crystallogr. Sect. D
D56
357-358
2000
Thermus filiformis
-
brenda
Lim, J.H.; Choi, J.; Kim, W.; Ahn, B.Y.; Han, Y.S.
Mutational analyses of Aquifex pyrophilus DNA ligase define essential domains for self-adenylation and DNA binding activity
Arch. Biochem. Biophys.
388
253-260
2001
Aquifex pyrophilus
brenda
Cao, W.
DNA ligases: Structure, function and mechanism
Curr. Org. Chem.
6
827-839
2002
Aquifex aeolicus, Bacillus subtilis, Melanoplus sanguinipes, Amsacta moorei entomopoxvirus
-
brenda
Lee, J.Y.; Chang, C.; Song, H.K.; Moon, J.; Yang, J.K.; Kim, H.K.; Kwon, S.T.; Suh, S.W.
Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications
EMBO J.
19
1119-1129
2000
Thermus filiformis (Q9ZHI0), Thermus filiformis
brenda
Georlette, D.; Jonsson, Z.O.; Van Petegem, F.; Chessa, J.P.; Van Beeumen, J.; Hubscher, U.; Gerday, C.
A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures
Eur. J. Biochem.
267
3502-3512
2000
Escherichia coli, Thermus scotoductus, Pseudoalteromonas haloplanktis (Q9RBF2)
brenda
Lim, J.H.; Choi, J.; Han, S.J.; Kim, S.H.; Hwang, H.Z.; Jin, D.K.; Ahn, B.Y.; Han, Y.S.
Molecular cloning and characterization of thermostable DNA ligase from Aquifex pyrophilus, a hyperthermophilic bacterium
Extremophiles
5
161-168
2001
Escherichia coli, Thermus aquaticus, Aquifex pyrophilus (Q9F150)
brenda
Kaczmarek, F.S.; Zaniewski, R.P.; Gootz, T.D.; Danley, D.E.; Mansour, M.N.; Griffor, M.; Kamath, A.V.; Cronan, M.; Mueller, J.; Sun, D.; Martin, P.K.; Benton, B.; McDowell, L.; Biek, D.; Schmid, M.B.
Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus
J. Bacteriol.
183
3016-3024
2001
Staphylococcus aureus
brenda
Sriskanda, V.; Moyer, R.W.; Shuman, S.
NAD+-dependent DNA ligase encoded by a eukaryotic virus
J. Biol. Chem.
276
36100-36109
2001
Amsacta moorei entomopoxvirus
brenda
Sriskanda, V.; Shuman, S.
Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+
J. Biol. Chem.
277
9695-9700
2002
Escherichia coli
brenda
Brotz-Oesterhelt, H.; Knezevic, I.; Bartel, S.; Lampe, T.; Warnecke-Eberz, U.; Ziegelbauer, K.; Habich, D.; Labischinski, H.
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
J. Biol. Chem.
278
39435-39442
2003
Escherichia coli
brenda
Georlette, D.; Blaise, V.; Dohmen, C.; Bouillenne, F.; Damien, B.; Depiereux, E.; Gerday, C.; Uversky, V.N.; Feller, G.
Cofactor Binding modulates the conformational stabilities and unfolding patterns of NAD+-dependent DNA ligases from Escherichia coli and Thermus scotoductus
J. Biol. Chem.
278
49945-49953
2003
Escherichia coli, Thermus scotoductus
brenda
Timson, D.J.; Wigley, D.B.
Functional domains of an NAD+-dependent DNA ligase
J. Mol. Biol.
285
73-83
1999
Geobacillus stearothermophilus
brenda
Sriskanda, V.; Schwer, B.; Ho, C.K.; Shuman, S.
Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4
Nucleic Acids Res.
27
3953-3963
1999
Escherichia coli
brenda
Tong, J.; Barany, F.; Cao, W.
Ligation reaction specificities of an NAD+-dependent DNA ligase from the hyperthermophile Aquifex aeolicus
Nucleic Acids Res.
28
1447-1454
2000
Aquifex aeolicus (O66880), Aquifex aeolicus
brenda
Sriskanda, V.; Shuman, S.
A second NAD+-dependent DNA ligase (LigB) in Escherichia coli
Nucleic Acids Res.
29
4930-4934
2001
Escherichia coli
brenda
Wilkinson, A.; Sayer, H.; Bullard, D.; Smith, A.; Day, J.; Kieser, T.; Bowater, R.
NAD+-dependent DNA ligases of Mycobacterium tuberculosis and Streptomyces coelicolor
Proteins Struct. Funct. Genet.
51
321-326
2003
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Streptomyces coelicolor, Streptomyces coelicolor A3(2)
brenda
Singleton, M.R.; Hakansson, K.; Timson, D.J.; Wigley, D.B.
Structure of the adenylation domain of an NAD+-dependent DNA ligase
Structure
7
35-42
1999
Geobacillus stearothermophilus
brenda
Zauner, G.; Wang, Y.; Lavesa-Curto, M.; MacDonald, A.; Mayes, A.G.; Bowater, R.P.; Butt, J.N.
Tethered DNA hairpins facilitate electrochemical detection of DNA ligation
Analyst
130
345-349
2005
Escherichia coli
brenda
Gul, S.; Brown, R.; May, E.; Mazzulla, M.; Smyth, M.G.; Berry, C.; Morby, A.; Powell, D.J.
Staphylococcus aureus DNA ligase: characterization of its kinetics of catalysis and development of a high-throughput screening compatible chemiluminescent hybridization protection assay
Biochem. J.
383
551-559
2004
Staphylococcus aureus
brenda
Feng, H.; Parker, J.M.; Lu, J.; Cao, W.
Effects of deletion and site-directed mutations on ligation steps of NAD+-dependent DNA ligase: a biochemical analysis of BRCA1 C-terminal domain
Biochemistry
43
12648-12659
2004
Thermus sp. AK16D
brenda
Lu, J.; Tong, J.; Feng, H.; Huang, J.; Afonso, C.L.; Rock, D.L.; Barany, F.; Cao, W.
Unique ligation properties of eukaryotic NAD+-dependent DNA ligase from Melanoplus sanguinipes entomopoxvirus
Biochim. Biophys. Acta
1701
37-48
2004
Melanoplus sanguinipes
brenda
Wilkinson, A.; Smith, A.; Bullard, D.; Lavesa-Curto, M.; Sayer, H.; Bonner, A.; Hemmings, A.; Bowater, R.
Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA)
Biochim. Biophys. Acta
1749
113-122
2005
Escherichia coli
brenda
Georlette, D.; Blaise, V.; Bouillenne, F.; Damien, B.; Thorbjarnardottir, S.H.; Depiereux, E.; Gerday, C.; Uversky, V.N.; Feller, G.
Adenylation-dependent conformation and unfolding pathways of the NAD+-dependent DNA ligase from the thermophile Thermus scotoductus
Biophys. J.
86
1089-1104
2004
Thermus scotoductus
brenda
Jeon, H.J.; Shin, H.J.; Choi, J.J.; Hoe, H.S.; Kim, H.K.; Suh, S.W.; Kwon, S.T.
Mutational analyses of the thermostable NAD+-dependent DNA ligase from Thermus filiformis
FEMS Microbiol. Lett.
237
111-118
2004
Thermus filiformis
brenda
Gong, C.; Martins, A.; Bongiorno, P.; Glickman, M.; Shuman, S.
Biochemical and genetic analysis of the four DNA ligases of mycobacteria
J. Biol. Chem.
279
20594-20606
2004
Mycobacterium tuberculosis
brenda
Zhu, H.; Shuman, S.
Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA)
J. Biol. Chem.
280
12137-12144
2005
Escherichia coli
brenda
Srivastava, S.K.; Tripathi, R.P.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors
J. Biol. Chem.
280
30273-30281
2005
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNV1)
brenda
Muerhoff, A.S.; Dawson, G.J.; Desai, S.M.
A non-isotopic method for the determination of activity of the thermostable NAD-dependent DNA ligase from Thermus thermophilus HB8
J. Virol. Methods
119
171-176
2004
Thermus thermophilus HB8
brenda
Lavesa-Curto, M.; Sayer, H.; Bullard, D.; MacDonald, A.; Wilkinson, A.; Smith, A.; Bowater, L.; Hemmings, A.; Bowater, R.P.
Characterization of a temperature-sensitive DNA ligase from Escherichia coli
Microbiology
150
4171-4180
2004
Escherichia coli, Escherichia coli DSM 3757
brenda
Gajiwala, K.S.; Pinko, C.
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal
Structure
12
1449-1459
2004
Enterococcus faecalis (Q837V6)
brenda
Feng, H.
Mutational analysis of bacterial NAD+-dependent DNA ligase: role of motif IV in ligation catalysis
Acta Biochim. Biophys. Sin.
39
608-616
2007
Thermus sp., Thermus sp. TAK16D
brenda
Miesel, L.; Kravec, C.; Xin, A.T.; McMonagle, P.; Ma, S.; Pichardo, J.; Feld, B.; Barrabee, E.; Palermo, R.
A high-throughput assay for the adenylation reaction of bacterial DNA ligase
Anal. Biochem.
366
9-17
2007
Escherichia coli
brenda
Korycka-Machala, M.; Rychta, E.; Brzostek, A.; Sayer, H.R.; Rumijowska-Galewicz, A.; Bowater, R.P.; Dziadek, J.
Evaluation of NAD+-dependent DNA ligase of mycobacteria as a potential target for antibiotics
Antimicrob. Agents Chemother.
51
2888-2897
2007
Mycolicibacterium smegmatis
brenda
Poidevin, L.; MacNeill, S.A.
Biochemical characterisation of LigN, an NAD+-dependent DNA ligase from the halophilic euryarchaeon Haloferax volcanii that displays maximal in vitro activity at high salt concentrations
BMC Mol. Biol.
7
44
2006
Haloferax volcanii
brenda
Blasius, M.; Buob, R.; Shevelev, I.V.; Hubscher, U.
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans
BMC Mol. Biol.
8
69
2007
Deinococcus radiodurans
brenda
Tomkinson, A.E.; Vijayakumar, S.; Pascal, J.M.; Ellenberger, T.
DNA ligases: Structure, reaction mechanism, and function
Chem. Rev.
106
687-699
2006
Enterococcus faecalis (Q837V6), Thermus filiformis (Q9ZHI0)
brenda
Nandakumar, J.; Nair, P.A.; Shuman, S.
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate
Mol. Cell
26
257-271
2007
Escherichia coli (P15042)
brenda
Zhao, A.; Gray, F.C.; MacNeill, S.A.
ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii
Mol. Microbiol.
59
743-752
2006
Haloferax volcanii
brenda
Srivastava, S.K.; Dube, D.; Kukshal, V.; Jha, A.K.; Hajela, K.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor
Proteins
69
97-111
2007
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNV1)
brenda
Benarroch, D.; Shuman, S.
Characterization of mimivirus NAD+-dependent DNA ligase
Virology
353
133-143
2006
Mimivirus
brenda
Vacek, J.; Cahova, K.; Palecek, E.; Bullard, D.R.; Lavesa-Curto, M.; Bowater, R.P.; Fojta, M.
Label-free electrochemical monitoring of DNA ligase activity
Anal. Chem.
80
7609-7613
2008
Escherichia coli
brenda
Li, J.; Jiang, J.H.; Xu, X.M.; Chu, X.; Jiang, C.; Shen, G.; Yu, R.Q.
Simultaneous identification of point mutations via DNA ligase-mediated gold nanoparticle assembly
Analyst
133
939-945
2008
Escherichia coli
brenda
Pascal, J.M.
DNA and RNA ligases: structural variations and shared mechanisms
Curr. Opin. Struct. Biol.
18
96-105
2008
Escherichia coli, Enterococcus faecalis, Thermus filiformis
brenda
Meier, T.I.; Yan, D.; Peery, R.B.; McAllister, K.A.; Zook, C.; Peng, S.B.; Zhao, G.
Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases
FEBS J.
275
5258-5271
2008
Streptococcus pneumoniae
brenda
Wang, L.K.; Nair, P.A.; Shuman, S.
Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase
J. Biol. Chem.
283
23343-23352
2008
Escherichia coli (P15042)
brenda
Dube, D.; Kukshal, V.; Srivastava, S.K.; Tripathi, R.P.; Ramachandran, R.
NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design
Med. Chem. Res.
17
189-198
2008
Mycobacterium tuberculosis (P9WNV1), Mycobacterium tuberculosis H37Rv (P9WNV1)
-
brenda
Dwivedi, N.; Dube, D.; Pandey, J.; Singh, B.; Kukshal, V.; Ramachandran, R.; Tripathi, R.P.
NAD+-dependent DNA ligase: a novel target waiting for the right inhibitor
Med. Res. Rev.
28
545-568
2008
Escherichia coli, Geobacillus stearothermophilus (O87703), Mycobacterium tuberculosis (P9WNV1), Enterococcus faecalis (Q837V6), Thermus filiformis (Q9ZHI0), Mycobacterium tuberculosis H37Rv (P9WNV1)
brenda
Le, D.; Hua, X.; Huang, L.; Gao, G.; Lu, H.; Xu, Z.; Tian, B.; Hua, Y.
Biochemical characterization of two DNA ligases from Deinococcus radiodurans
Protein Pept. Lett.
15
600-605
2008
Deinococcus radiodurans
brenda
Han, S.; Chang, J.S.; Griffor, M.
Structure of the adenylation domain of NAD+-dependent DNA ligase from Staphylococcus aureus
Acta Crystallogr. Sect. F
65
1078-1082
2009
Staphylococcus aureus (Q9AIU7), Staphylococcus aureus
brenda
Luan, Q.; Xue, Y.; Yao, X.; Lu, W.
Hairpin DNA probe based surface plasmon resonance biosensor used for the activity assay of E. coli DNA ligase
Analyst
135
414-418
2010
Escherichia coli
brenda
Ignatov, K.B.; Kramarov, V.M.
DNA ligases from thermophilic bacteria enhance PCR amplification of long DNA sequences
Biochemistry
74
557-561
2009
Thermus thermophilus, Thermus aquaticus
brenda
Yutin, N.; Koonin, E.V.
Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity
Biol. Direct
4
51
2009
Brachyspira hyodysenteriae, Acanthamoeba polyphaga Mimivirus, Sorangium cellulosum, Aquifex aeolicus VF5, Candidatus Blochmannia floridanus, Acidithiobacillus ferrooxidans ATCC 23270, Melanoplus sanguinipes entomopoxvirus, Amsacta moorei entomopoxvirus, Invertebrate iridescent virus 6, Aedes taeniorhynchus iridescent virus, Ralstonia phage phiRSL1, Lentisphaera araneosa HTCC2155, Marinobacter sp. ELB17, Desulfatibacillum alkenivorans AK-01, Desulfuromonas acetoxidans DSM 684, Natronomonas pharaonis DSM 2160, Haloquadratum walsbyi DSM 16790, Ostreococcus lucimarinus CCE9901, Rickettsia felis URRWXCal2, Methylacidiphilum infernorum V4, Nitratiruptor sp. SB155-2, Leptotrichia buccalis C-1013-b, Dictyostelium discoideum AX4, Borrelia hermsii HS1, Bacillus thuringiensis Bt407, Clostridium carboxidivorans P7, Plesiocystis pacifica SIR-1
brenda
Doi, A.; Pack, S.P.; Makino, K.
Comparison of the molecular influences of NO-induced lesions in DNA strands on the reactivity of polynucleotide kinases, DNA ligases and DNA polymerases
J. Biochem.
147
697-703
2010
Tequatrovirus T4, Thermus aquaticus
brenda
Shuman, S.
DNA ligases: progress and prospects
J. Biol. Chem.
284
17365-17369
2009
Escherichia coli (P15042), Enterococcus faecalis (Q837V6)
brenda
Singh, V.; Somvanshi, P.
Toward the virtual screening of potential drugs in the homology modeled NAD+ dependent DNA ligase from Mycobacterium tuberculosis
Protein Pept. Lett.
17
269-276
2010
Mycobacterium tuberculosis
brenda
Mills, S.D.; Eakin, A.E.; Buurman, E.T.; Newman, J.V.; Gao, N.; Huynh, H.; Johnson, K.D.; Lahiri, S.; Shapiro, A.B.; Walkup, G.K.; Yang, W.; Stokes, S.S.
Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo
Antimicrob. Agents Chemother.
55
1088-1096
2011
Escherichia coli, Escherichia coli MG1655, Haemophilus influenzae, Haemophilus influenzae KW20, Mycoplasma pneumoniae, Mycoplasma pneumoniae M29, Staphylococcus aureus, Staphylococcus aureus RN4220, Streptococcus pneumoniae
brenda
Le, Y.; Peng, J.; Pei, J.; Li, H.; Duan, Z.; Shao, W.
Properties of an NAD+-dependent DNA ligase from the hyperthermophile Thermotoga maritima and its application in PCR amplification of long DNA fragments
Enzyme Microb. Technol.
46
113-117
2010
Thermotoga maritima, Thermotoga maritima ATCC 43589
-
brenda
Shapiro, A.B.; Eakin, A.E.; Walkup, G.K.; Rivin, O.
A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase
J. Biomol. Screen.
16
486-493
2011
Haemophilus influenzae
brenda
Akhoon, B.A.; Gupta, S.K.; Dhaliwal, G.; Srivastava, M.; Gupta, S.K.
Virtual screening of specific chemical compounds by exploring E.coli NAD+-dependent DNA ligase as a target for antibacterial drug discovery
J. Mol. Model.
17
265-273
2011
Escherichia coli
brenda
He, X.; Ni, X.; Wang, Y.; Wang, K.; Jian, L.
Electrochemical detection of nicotinamide adenine dinucleotide based on molecular beacon-like DNA and E. coli DNA ligase
Talanta
83
937-942
2011
Escherichia coli
brenda
Jahic, H.; Liu, C.F.; Thresher, J.; Livchak, S.; Wang, H.; Ehmann, D.E.
The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds
Biochem. Pharmacol.
84
654-660
2012
Streptococcus pneumoniae
brenda
Stokes, S.S.; Huynh, H.; Gowravaram, M.; Albert, R.; Cavero-Tomas, M.; Chen, B.; Harang, J.; Loch, J.T.; Lu, M.; Mullen, G.B.; Zhao, S.; Liu, C.F.; Mills, S.D.
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity
Bioorg. Med. Chem. Lett.
21
4556-4560
2011
Streptococcus pneumoniae, Staphylococcus aureus
brenda
Wang, T.; Duncan, L.; Gu, W.; ODowd, H.; Wei, Y.; Perola, E.; Parsons, J.; Gross, C.H.; Moody, C.S.; Arends, S.J.; Charifson, P.S.
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
Bioorg. Med. Chem. Lett.
22
3699-3703
2012
Escherichia coli
brenda
Surivet, J.P.; Lange, R.; Hubschwerlen, C.; Keck, W.; Specklin, J.L.; Ritz, D.; Bur, D.; Locher, H.; Seiler, P.; Strasser, D.S.; Prade, L.; Kohl, C.; Schmitt, C.; Chapoux, G.; Ilhan, E.; Ekambaram, N.; Athanasiou, A.; Knezevic, A.; Sabato, D.; Chambovey, A.; Gaertner, M.; Enderlin, M.; Boehme, M.; Sipp, S.i.p.p.e.
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity
Bioorg. Med. Chem. Lett.
22
6705-6711
2012
Escherichia coli
brenda
Murphy-Benenato, K.; Wang, H.; McGuire, H.M.; Davis, H.E.; Gao, N.; Prince, D.B.; Jahic, H.; Stokes, S.S.; Boriack-Sjodin, P.A.
Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations
Bioorg. Med. Chem. Lett.
24
360-366
2014
Streptococcus pneumoniae, Enterococcus faecalis, Haemophilus influenzae, Staphylococcus aureus
brenda
Shrivastava, N.; Nag, J.K.; Misra-Bhattacharya, S.
Molecular characterization of NAD+-dependent DNA ligase from Wolbachia endosymbiont of lymphatic filarial parasite Brugia malayi
PLoS ONE
7
e41113
2012
Wolbachia endosymbiont of Brugia malayi
brenda
Jiang, C.; Kan, Y.Y.; Jiang, J.H.; Yu, R.Q.
A simple and highly sensitive DNAzyme-based assay for nicotinamide adenine dinucleotide by ligase-mediated inhibition of strand displacement amplification
Anal. Chim. Acta
844
70-74
2014
Escherichia coli
brenda
Shrivastava, N.; Nag, J.K.; Pandey, J.; Tripathi, R.P.; Shah, P.; Siddiqi, M.I.; Misra-Bhattacharya, S.
Homology modeling of NAD+-dependent DNA ligase of the Wolbachia endosymbiont of Brugia malayi and its drug target potential using dispiro-cycloalkanones
Antimicrob. Agents Chemother.
59
3736-3747
2015
Wolbachia sp. subsp. Brugia malayi (Q5GS88), Wolbachia sp. subsp. Brugia malayi TRS (Q5GS88)
brenda
Murphy-Benenato, K.E.; Gingipalli, L.; Boriack-Sjodin, P.A.; Martinez-Botella, G.; Carcanague, D.; Eyermann, C.J.; Gowravaram, M.; Harang, J.; Hale, M.R.; Ioannidis, G.; Jahic, H.; Johnstone, M.; Kutschke, A.; Laganas, V.A.; Loch, J.T.; Miller, M.D.; Oguto, H.; Patel, S.J.
Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development
Bioorg. Med. Chem. Lett.
25
5172-5177
2015
Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Haemophilus influenzae ARM158, Escherichia coli ARC524, Streptococcus pneumoniae ARC548, Staphylococcus aureus ARC561
brenda
Pergolizzi, G.; Wagner, G.K.; Bowater, R.P.
Biochemical and structural characterisation of DNA ligases from bacteria and archaea
Biosci. Rep.
36
e00391
2016
Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Mycobacterium tuberculosis, Mycoplasma pneumoniae
brenda
Shapiro, A.B.
Complete steady-state rate equation for DNA ligase and its use for measuring product kinetic parameters of NAD+-dependent DNA ligase from Haemophilus influenzae
BMC Res. Notes
7
287
2014
Haemophilus influenzae
brenda
Sorci, L.; Ruggieri, S.; Raffaelli, N.
NAD homeostasis in the bacterial response to DNA/RNA damage
DNA Repair
23
17-26
2014
Gluconobacter oxydans, Oleidesulfovibrio alaskensis, Desulfovibrio vulgaris, Syntrophotalea carbinolica, Thermotoga maritima, Synechococcus elongatus, Lawsonia intracellularis
brenda
Giroux, X.; MacNeill, S.A.
Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii
FEMS Microbiol. Lett.
362
pii: fnv181
2015
Haloferax volcanii
brenda
Korycka-Machala, M.; Nowosielski, M.; Kuron, A.; Rykowski, S.; Olejniczak, A.; Hoffmann, M.; Dziadek, J.
Naphthalimides selectively inhibit the activity of bacterial, replicative DNA ligases and display bactericidal effects against tubercle bacilli
Molecules
22
pii: E154
2017
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Chauleau, M.; Shuman, S.
Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA)
Nucleic Acids Res.
44
2298-2309
2016
Escherichia coli
brenda
Konomura, N.; Arai, N.; Shinohara, T.; Kobayashi, J.; Iwasaki, W.; Ikawa, S.; Kusano, K.; Shibata, T.
Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions
Nucleic Acids Res.
45
337-352
2017
Escherichia coli
brenda
Yadav, N.; Khanam, T.; Shukla, A.; Rai, N.; Hajela, K.; Ramachandran, R.
Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I
Org. Biomol. Chem.
13
5475-5487
2015
Mycobacterium tuberculosis
brenda
Pergolizzi, G.; Cominetti, M.M.; Butt, J.N.; Field, R.A.; Bowater, R.P.; Wagner, G.K.
Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases
Org. Biomol. Chem.
13
6380-6398
2015
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Hale, M.; Brassington, C.; Carcanague, D.; Embrey, K.; Eyermann, C.; Giacobbe, R.; Gingipalli, L.; Gowravaram, M.; Harang, J.; Howard, T.; Ioannidis, G.; Jahic, H.; Kutschke, A.; Laganas, V.; Loch, J.; Miller, M.; Murphy-Benenato, K.; Oguto, H.; Otterbein, L-; Patel, S.J.; Sapiro, A.B.; Boriack-Sjodin, A.
From fragments to leads Novel bacterial NAD+-dependent DNA ligase inhibitors
Tetrahedron Lett.
56
3108-3112
2015
Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae (P43813), Streptococcus pneumoniae ATCC 10813, Staphylococcus aureus ATCC 29213
-
brenda