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Literature summary for 6.5.1.2 extracted from
- DNA ligases: progress and prospects (2009), J. Biol. Chem., 284, 17365-17369.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-methylthio-ATP | potent inhibitor | Enterococcus faecalis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | Q837V6 | - |
- |
| Escherichia coli | P15042 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Enterococcus faecalis | AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m | - |
? | |
| NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Escherichia coli | AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LigA | - |
Enterococcus faecalis |
| LigA | - |
Escherichia coli |
| NAD+-dependent DNA ligase | - |
Enterococcus faecalis |
| NAD+-dependent DNA ligase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Enterococcus faecalis | |
| NAD+ | - |
Escherichia coli | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
- |
Enterococcus faecalis | 2-methylthio-ATP | |
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