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Literature summary for 6.5.1.2 extracted from

  • Pascal, J.M.
    DNA and RNA ligases: structural variations and shared mechanisms (2008), Curr. Opin. Struct. Biol., 18, 96-105.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Escherichia coli
-
Enterococcus faecalis
-
Thermus filiformis

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Escherichia coli
-
-
-
Thermus filiformis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain Escherichia coli AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain Enterococcus faecalis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m in addition to the unique N-terminal domain Ia that stimulates ligase-AMP formation, there are three C-terminal domains that extend from the OB domain: a small zinc-binding (Zn) domain, a helix-hairpin-helix domain, and a BRCA1 C-terminal domain Thermus filiformis AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m
-
?

Synonyms

Synonyms Comment Organism
DNA ligase
-
Escherichia coli
DNA ligase
-
Enterococcus faecalis
DNA ligase
-
Thermus filiformis
LigA
-
Escherichia coli
LigA
-
Enterococcus faecalis
LigA
-
Thermus filiformis
NAD+-dependent DNA ligase
-
Escherichia coli
NAD+-dependent DNA ligase
-
Enterococcus faecalis
NAD+-dependent DNA ligase
-
Thermus filiformis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli
NAD+
-
Enterococcus faecalis
NAD+
-
Thermus filiformis