Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of just the BRCT domain from MtuLigA results in total loss of activity in in vitro assays | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole | - |
Mycobacterium tuberculosis | |
N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine | - |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00146 | - |
NAD+ | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | in presence of Ca2+ MtuLigA is able to carry out the first two steps of ligation reaction that is the transfer of AMP to enzyme from NAD+ and further transfer of it to substrate to form DNA-adenylate intermediate. Ca2+ can not support nick closure activity | Mycobacterium tuberculosis | |
Mg2+ | divalent cation required, optimal concentration: 10 mM | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WNV1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WNV1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Mycobacterium tuberculosis | AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m | - |
? | |
NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Mycobacterium tuberculosis H37Rv | AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MtuLigA | - |
Mycobacterium tuberculosis |
NAD+-dependent DNA ligase | - |
Mycobacterium tuberculosis |
Rv3014c | - |
Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Mycobacterium tuberculosis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9.5 | more than 60% of maximal activity between pH 7.5 and 8.5 | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0135 | - |
- |
Mycobacterium tuberculosis | 12-(6-piperidin-1-ylhexyl)-7,12-dihydro-6H-[1]benzothiepino[5,4-b]indole | |
0.046 | - |
- |
Mycobacterium tuberculosis | N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentame-1,4-diamine |