Reference on EC 2.7.1.20 - adenosine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lazou, A.; Beis, I.
Enzymes of adenosine metabolism in Rana ridibunda heart
Mol. Physiol.
8
131-142
1985
Pelophylax ridibundus
-
Lobelle-Rich, P.A.; Reeves, R.E.
The partial purification and characterization of adenosine kinase from Entamoeba histolytica
Am. J. Trop. Med. Hyg.
32
976-979
1983
Entamoeba histolytica
De Jong, J.W.
Partial purification and properties of rat heart adenosine kinase
Arch. Int. Physiol. Biochim.
85
557-569
1977
Rattus norvegicus
Chen, C.M.; Eckert, R.L.
Phosphorylation of cytokinin by adenosine kinase from wheat germ
Plant Physiol.
59
443-447
1977
Nicotiana tabacum, Triticum aestivum
Divekar, A.Y.; Hakala, M.T.; Chheda, G.B.; Hong, C.I.
6-Ureido derivatives of 9-(-D-ribofuranosyl)purine as inhibitors of adenosine kinase
Biochem. Pharmacol.
22
545-548
1973
Mus musculus
Lindberg, B.; Klenow, H.; Hansen, K.
Some properties of partially purified mammalian adenosine kinase
J. Biol. Chem.
242
350-356
1967
Oryctolagus cuniculus, Mus musculus
Yamada, Y.; Goto, H.; Ogasawara, N.
Purine nucleoside kinases in human T- and B-lymphoblasts
Biochim. Biophys. Acta
761
34-40
1983
Homo sapiens
De Jong, J.W.; Kalkman, C.
Myocardial adenosine kinase: activity and localization determined with rapid, radiometric assay
Biochim. Biophys. Acta
320
388-396
1973
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Rattus norvegicus, Rattus norvegicus Wistar
Hawkins, C.F.; Bagnara, A.S.
Adenosine kinase from human erythrocytes: kinetic studies and characterization of adenosine binding sites
Biochemistry
26
1982-1987
1987
Homo sapiens
Andres, C.M.; Fox, I.H.
Purification and properties of human placental adenosine kinase
J. Biol. Chem.
254
11388-11393
1979
Homo sapiens
Palella, T.D.; Andres, C.M.; Fox, I.H.
Human placental adenosine kinase. Kinetic mechanism and inhibition
J. Biol. Chem.
255
5264-5269
1980
Homo sapiens
Yamada, Y.; Goto, H.; Ogasawara, N.
Adenosine kinase from human liver
Biochim. Biophys. Acta
660
36-43
1981
Homo sapiens
Bone, R.; Cheng, Y.C.; Wolfenden, R.
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs
J. Biol. Chem.
261
16410-16413
1986
Homo sapiens
Rotllan, P.; Miras Portugal, M.T.
Adenosine kinase from bovine adrenal medulla
Eur. J. Biochem.
151
365-371
1985
Bos taurus
Miller, R.L.; Adamczyk, D.L.; Miller, W.H.
Adenosine kinase from rabbit liver. I. Purification by affinity chromatography and properties
J. Biol. Chem.
254
2339-2345
1979
Oryctolagus cuniculus
Miller, R.L.; Adamczyk, D.L.; Miller, W.H.; Koszalka, G.W.; Rideout, J.L.; Beacham, L.M.; Chao, E.Y.; Haggerty, J.J.; Krenitsky, T.A.; Elion, G.B.
Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity
J. Biol. Chem.
254
2346-2352
1979
Oryctolagus cuniculus
Drabikowska, A.K.; Halec, L.; Shugar, D.
Purification and properties of adenosine kinase from rat liver: separation from deoxyadenosine kinase activity
Z. Naturforsch. C
40
34-41
1985
Rattus norvegicus
Yamada, Y.; Goto, H.; Ogasawara, N.
Purification and properties of adenosine kinase from rat brain
Biochim. Biophys. Acta
616
199-207
1980
Rattus norvegicus
Fisher, M.N.; Newsholme, E.A.
Properties of rat heart adenosine kinase
Biochem. J.
221
521-528
1984
Rattus norvegicus, Rattus norvegicus Wistar
Mimouni, M.; Bontemps, F.; Van den Berghe, G.
Kinetic studies of rat liver adenosine kinase. Explanation of exchange reaction between adenosine and AMP
J. Biol. Chem.
269
17820-17825
1994
Rattus norvegicus, Rattus norvegicus Wistar
Chang, C.H.; Brockman, R.W.; Bennett, L.L.
Adenosine kinase from L1210 cells. Purification and some properties of the enzyme
J. Biol. Chem.
255
2366-2371
1980
Mus musculus
Henderson, J.F.; Mikoshiba, A.; Chu, S.Y.; Caldwell, I.C.
Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells
J. Biol. Chem.
247
1972-1975
1972
Mus musculus
Guranowski, A.
Plant adenosine kinase: purification and some properties of the enzyme from Lupinus luteus seeds
Arch. Biochem. Biophys.
196
220-226
1979
Lupinus luteus
Kidder, G.W.
Adenosine kinase from Trypanosoma cruzi
Biochem. Biophys. Res. Commun.
107
381-388
1982
Trypanosoma cruzi
Datta, A.K.; Bhaumik, D.; Chatterjee, R.
Isolation and characterization of adenosine kinase from Leishmania donovani
J. Biol. Chem.
262
5515-5521
1987
Leishmania donovani, Leishmania donovani UR6
Bhaumik, D.; Datta, A.K.
Immunochemical and catalytic characteristics of adenosine kinase from Leishmania donovani
J. Biol. Chem.
264
4356-4361
1989
Leishmania donovani
Carson, D.A.; Kaye, J.; Seegmiller, J.E.
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s)
Proc. Natl. Acad. Sci. USA
74
5677-5681
1977
Homo sapiens
Leibach, T.K.; Spiess, G.I.; Neudecker, T.J.; Peschke, G.J.; Puchwein, G.; Hartmann, G.R.
Purification and properties of adenosine kinase from dried brewers yeast
Hoppe-Seyler's Z. Physiol. Chem.
352
328-344
1971
Saccharomyces cerevisiae
Schmidt, G.; Walker, R.D.; Konigk, E.
Adenosine kinase from normal mouse erythrocytes and from Plasmodium chabaudi: partial purification and characterization
Tropenmed. Parasitol.
25
301-308
1974
Plasmodium chabaudi
von Schwartzenberg, K.; Kruse, S.; Reski, R.; Moffatt, B.; Laloue, M.
Cloning and characterization of an adenosine kinase from Physcomitrella involved in cytokinin metabolism
Plant J.
13
249-257
1998
Physcomitrium patens
Recacha, R.; Talalaev, A.; DeLucas, L.J.; Chattopadhyay, D.
Toxoplasma gondii adenosine kinase: expression, purification, characterization, crystallization and preliminary crystallographic analysis
Acta Crystallogr. Sect. D
56
76-78
2000
Toxoplasma gondii
Carret, C.; Delbecq, S.; Labesse, G.; Carcy, B.; Precigout, E.; Moubri, K.; Schetters, T.P.; Gorenflot, A.
Characterization and molecular cloning of an adenosine kinase from Babesia canis rossi
Eur. J. Biochem.
265
1015-1021
1999
Babesia canis rossi
Barrado, P.; Rodriguez, M.J.; Jimenez, A.; Lobato, M.F.
Expression in Escherichia coli of a recombinant adenosine kinase from Saccharomyces cerevisiae: purification, kinetics and substrate analyses
Yeast
20
1145-1150
2003
Saccharomyces cerevisiae
Faye, F.; Le Floc'h, F.
Adenosine kinase of peach tree flower buds: purification and properties
Plant Physiol. Biochem.
35
15-22
1997
Prunus persica
-
Faye, F.; Le Floc'h, F.
Changes in the activity of peach bud adenosine kinase from the dormancy period to bud break
J. Plant Physiol.
154
471-476
1999
Prunus persica
-
Laukens, K.; Lenobel, R.; Strnad, M.; Van Onckelen, H.; Witters, E.
Cytokinin affinity purification and identification of a tobacco BY-2 adenosine kinase
FEBS Lett.
533
63-66
2003
Nicotiana tabacum
Schumacher, M.A.; Scott, D.M.; Mathews, I.I.; Ealick, S.E.; Roos, D.S.; Ullman, B.; Brennan, R.G.
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding
J. Mol. Biol.
296
549-567
2000
Toxoplasma gondii
Maj, M.C.; Singh, B.; Gupta, R.S.
Structure-Activity Studies on Mammalian Adenosine Kinase
Biochem. Biophys. Res. Commun.
275
386-393
2000
Cricetulus griseus
Maj, M.; Singh, B.; Gupta, R.S.
The influence of inorganic phosphate on the activity of adenosine kinase
Biochim. Biophys. Acta
1476
33-42
2000
Bos taurus, Cricetulus griseus
Cook, W.J.; DeLucas, L.J.; Chattopadhyay, D.
Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 A resolution
Protein Sci.
9
704-712
2000
Toxoplasma gondii
Sinha, K.M.; Ghosh, M.; Das, I.; Datta, A.K.
Molecular cloning and expression of adenosine kinase from Leishmania donovani: identification of unconventional P-loop motif
Biochem. J.
339
667-673
1999
Leishmania donovani
-
Mathews, I.I.; Erion, M.D.; Ealick, S.E.
Structure of human adenosine kinase at 1.5.ANG. resolution
Biochemistry
37
15607-15620
1998
Homo sapiens (P55263), Homo sapiens
Xiao-Bing, L.V.; Hai-Zhen, W.U.; Jiang, Y.E.; Yi, F.; Hui-Zhan, Z.
Expression, purification and characterization of recombinant Saccharomyces cerevisiae adenosine kinase
Acta Biochim. Biophys. Sin.
35
666-670
2003
Saccharomyces cerevisiae
Wu, J.Z.; Larson, G.; Walker, H.; Shim, J.H.; Hong, Z.
Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes
Antimicrob. Agents Chemother.
49
2164-2171
2005
Cricetulus griseus
Datta, R.; Das, I.; Sen, B.; Chakraborty, A.; Adak, S.; Mandal, C.; Datta, A.K.
Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani
Biochem. J.
387
591-600
2005
Leishmania donovani
Rais, R.H.; Al Safarjalani, O.N.; Yadav, V.; Guarcello, V.; Kirk, M.; Chu, C.K.; Naguib, F.N.; el Kouni, M.H.
6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities
Biochem. Pharmacol.
69
1409-1419
2005
Toxoplasma gondii
Sahin, B.; Kansy, J.W.; Nairn, A.C.; Spychala, J.; Ealick, S.E.; Fienberg, A.A.; Greene, R.W.; Bibb, J.A.
Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation
Eur. J. Biochem.
271
3547-3555
2004
Mus musculus (P55264), Mus musculus
Schoor, S.; Moffatt, B.A.
Applying high throughput techniques in the study of adenosine kinase in plant metabolism and development
Front. Biosci.
9
1771-1781
2004
Arabidopsis thaliana, Avicennia marina, Solanum lycopersicum, Medicago truncatula, Nicotiana tabacum, Physcomitrium patens, Populus sp., Spinacia oleracea
Long, M.C.; Escuyer, V.; Parker, W.B.
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis
J. Bacteriol.
185
6548-6555
2003
Mycobacterium tuberculosis (A5U4N0), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra / ATCC 25177 (A5U4N0)
Kwade, Z.; Swiatek, A.; Azmi, A.; Goossens, A.; Inze, D.; Van Onckelen, H.; Roef, L.
Identification of four adenosine kinase isoforms in tobacco By-2 cells and their putative role in the cell cycle-regulated cytokinin metabolism
J. Biol. Chem.
280
17512-17519
2005
Nicotiana tabacum (Q5DKU6), Nicotiana tabacum (Q5DKU8), Nicotiana tabacum (Q5DKU9), Nicotiana tabacum (Q5DKV0), Nicotiana tabacum
Wang, H.; Hao, L.; Shung, C.Y.; Sunter, G.; Bisaro, D.M.
Adenosine kinase is inactivated by geminivirus AL2 and L2 proteins
Plant Cell
15
3020-3032
2003
Nicotiana benthamiana, Arabidopsis thaliana (Q9LZG0)
Park, J.; Singh, B.; Maj, M.C.; Gupta, R.S.
Phosphorylated derivatives that activate or inhibit mammalian adenosine kinase provide insights into the role of pentavalent ions in AK catalysis
Protein J.
23
167-177
2004
Cricetulus griseus
Zhang, Y.; El Kouni, M.H.; Ealick, S.E.
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 A resolution
Acta Crystallogr. Sect. D
62
140-145
2006
Toxoplasma gondii (Q9TVW2), Toxoplasma gondii
Zhang, Y.; El Kouni, M.H.; Ealick, S.E.
Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase
Acta Crystallogr. Sect. D
63
126-134
2007
Toxoplasma gondii (Q9TVW2), Toxoplasma gondii
Wang, Y.; Long, M.C.; Ranganathan, S.; Escuyer, V.; Parker, W.B.; Li, R.
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
553-557
2005
Mycobacterium tuberculosis
Luescher, A.; Onal, P.; Schweingruber, A.M.; Maeser, P.
Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites
Antimicrob. Agents Chemother.
51
3895-3901
2007
Trypanosoma brucei
Datta, R.; Das, I.; Sen, B.; Chakraborty, A.; Adak, S.; Mandal, C.; Datta, A.K.
Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani
Biochem. J.
394
35-42
2006
Leishmania donovani
Long, M.C.; Parker, W.B.
Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety
Biochem. Pharmacol.
71
1671-1682
2006
Homo sapiens, Mycobacterium tuberculosis
Sen, B.; Chakraborty, A.; Datta, R.; Bhattacharyya, D.; Datta, A.K.
Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation
Biochemistry
45
263-271
2006
Leishmania donovani
Sen, B.; Venugopal, V.; Chakraborty, A.; Datta, R.; Dolai, S.; Banerjee, R.; Datta, A.K.
Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications
Biochemistry
46
7832-7843
2007
Leishmania donovani
Matulenko, M.A.; Paight, E.S.; Frey, R.R.; Gomtsyan, A.; DiDomenico, S.; Jiang, M.; Lee, C.H.; Stewart, A.O.; Yu, H.; Kohlhaas, K.L.; Alexander, K.M.; McGaraughty, S.; Mikusa, J.; Marsh, K.C.; Muchmore, S.W.; Jakob, C.L.; Kowaluk, E.A.; Jarvis, M.F.; Bhagwat, S.S.
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors
Bioorg. Med. Chem.
15
1586-1605
2007
Mus musculus
Kumarapperuma, S.C.; Sun, Y.; Jeselnik, M.; Chung, K.; Parker, W.B.; Jonsson, C.B.; Arterburn, J.B.
Structural effects on the phosphorylation of 3-substituted 1-beta-D-ribofuranosyl-1,2,4-triazoles by human adenosine kinase
Bioorg. Med. Chem. Lett.
17
3203-3207
2007
Homo sapiens
Iqbal, J.; Burbiel, J.C.; Mueller, C.E.
Development of off-line and on-line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates
Electrophoresis
27
2505-2517
2006
Bos taurus
Long, M.C.; Allan, P.W.; Luo, M.Z.; Liu, M.C.; Sartorelli, A.C.; Parker, W.B.
Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth
J. Antimicrob. Chemother.
59
118-121
2007
Homo sapiens, Mycobacterium tuberculosis
Reddy, M.C.; Palaninathan, S.K.; Shetty, N.D.; Owen, J.L.; Watson, M.D.; Sacchettini, J.C.
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: Insights into the mechanism and specificity of this novel prokaryotic enzyme
J. Biol. Chem.
282
27334-27342
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WID5), Mycobacterium tuberculosis H37Rv (P9WID5)
Pignataro, G.; Maysami, S.; Studer, F.E.; Wilz, A.; Simon, R.P.; Boison, D.
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism
J. Cereb. Blood Flow Metab.
28
17-23
2007
Mus musculus
Bookser, B.C.; Matelich, M.C.; Ollis, K.; Ugarkar, B.G.
Adenosine kinase inhibitors. 4. 6,8-disubstituted purine nucleoside derivatives. Synthesis, conformation, and enzyme inhibition
J. Med. Chem.
48
3389-3399
2005
Homo sapiens
Boyer, S.H.; Ugarkar, B.G.; Solbach, J.; Kopcho, J.; Matelich, M.C.; Ollis, K.; Gomez-Galeno, J.E.; Mendonca, R.; Tsuchiya, M.; Nagahisa, A.; Nakane, M.; Wiesner, J.B.; Erion, M.D.
Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues
J. Med. Chem.
48
6430-6441
2005
Homo sapiens
Galazka, J.; Striepen, B.; Ullman, B.
Adenosine kinase from Cryptosporidium parvum
Mol. Biochem. Parasitol.
149
223-230
2006
Cryptosporidium parvum
Park, J.; Singh, B.; Gupta, R.S.
Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives
Mol. Cell. Biochem.
283
11-21
2006
Cricetulus griseus
Studer, F.E.; Fedele, D.E.; Marowsky, A.; Schwerdel, C.; Wernli, K.; Vogt, K.; Fritschy, J.M.; Boison, D.
Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme
Neuroscience
142
125-137
2006
Mus musculus
Young, L.S.; Harrison, B.R.; Narayana Murthy, U.M.; Moffatt, B.A.; Gilroy, S.; Masson, P.H.
Adenosine kinase modulates root gravitropism and cap morphogenesis in Arabidopsis
Plant Physiol.
142
564-573
2006
Arabidopsis thaliana (Q9SF85)
Park, J.; Vaidyanathan, G.; Singh, B.; Gupta, R.S.
Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase
Protein J.
26
203-212
2007
Homo sapiens
Rajkarnikar, A.; Kwon, H.J.; Suh, J.W.
Role of adenosine kinase in the control of Streptomyces differentiations: Loss of adenosine kinase suppresses sporulation and actinorhodin biosynthesis while inducing hyperproduction of undecylprodigiosin in Streptomyces lividans
Biochem. Biophys. Res. Commun.
363
322-328
2007
Streptomyces lividans
Long, M.C.; Shaddix, S.C.; Moukha-Chafiq, O.; Maddry, J.A.; Nagy, L.; Parker, W.B.
Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety
Biochem. Pharmacol.
75
1588-1600
2008
Homo sapiens, Mycobacterium tuberculosis (P9WID5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WID5)
Al Safarjalani, O.N.; Rais, R.H.; Ah Kim, Y.; Chu, C.K.; Naguib, F.N.; El Kouni, M.H.
7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities
Biochem. Pharmacol.
76
958-966
2008
Toxoplasma gondii
Caballero, J.; Fernandez, M.; Gonzalez-Nilo, F.D.
A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues
Bioorg. Med. Chem.
16
5103-5108
2008
Homo sapiens
Morote-Garcia, J.C.; Rosenberger, P.; Kuhlicke, J.; Eltzschig, H.K.
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
Blood
111
5571-5580
2008
Homo sapiens
Park, J.; Gupta, R.S.
Adenosine kinase and ribokinase - the RK family of proteins
Cell. Mol. Life Sci.
65
2875-2896
2008
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Leishmania donovani, Schizosaccharomyces pombe, Spinacia oleracea, Trypanosoma brucei, Homo sapiens (P55263)
Yee, B.K.; Singer, P.; Chen, J.F.; Feldon, J.; Boison, D.
Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs
Eur. J. Neurosci.
26
3237-3252
2007
Mus musculus
Ren, G.; Li, T.; Lan, J.Q.; Wilz, A.; Simon, R.P.; Boison, D.
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control
Exp. Neurol.
208
26-37
2007
Homo sapiens
Yu, L.; Gao, Y.F.; Qiao, Z.P.; Li, C.L.; Li, X.; Shen, J.L.
Toxoplasma gondii: siRNA can mediate the suppression of adenosine kinase expression
Exp. Parasitol.
118
96-102
2008
Toxoplasma gondii (Q9TVW2), Toxoplasma gondii
Vodnala, M.; Fijolek, A.; Rofougaran, R.; Mosimann, M.; Maeser, P.; Hofer, A.
Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei
J. Biol. Chem.
283
5380-5388
2008
Trypanosoma brucei
Pignataro, G.; Simon, R.P.; Boison, D.
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia
J. Cereb. Blood Flow Metab.
27
1-5
2007
Mus musculus
Li, T.; Ren, G.; Lusardi, T.; Wilz, A.; Lan, J.Q.; Iwasato, T.; Itohara, S.; Simon, R.P.; Boison, D.
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
J. Clin. Invest.
118
571-582
2008
Mus musculus
Kim, Y.A.; Sharon, A.; Chu, C.K.; Rais, R.H.; Al Safarjalani, O.N.; Naguib, F.N.; el Kouni, M.H.
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase
J. Med. Chem.
51
3934-3945
2008
Toxoplasma gondii
Giglioni, S.; Leoncini, R.; Aceto, E.; Chessa, A.; Civitelli, S.; Bernini, A.; Tanzini, G.; Carraro, F.; Pucci, A.; Vannoni, D.
Adenosine kinase gene expression in human colorectal cancer
Nucleosides Nucleotides Nucleic Acids
27
750-754
2008
Homo sapiens
Vannoni, D.; Giglioni, S.; Santoro, A.; Aceto, E.; Marinello, E.; Leoncini, R.
A kinetic study of the rat liver adenosine kinase reverse reaction
Nucleosides Nucleotides Nucleic Acids
27
872-875
2008
Rattus norvegicus
Wu, N.L.; Boison, D.
Adenosine kinase expression modulates expression of myelin proteolipid protein
Open Neurosci. J.
1
15-19
2007
Mus musculus
-
Yu, L.; Gao, Y.F.; Li, X.; Qiao, Z.P.; Shen, J.L.
Double-stranded RNA specific to adenosine kinase and hypoxanthine-xanthine-guanine-phosphoribosyltransferase retards growth of Toxoplasma gondii
Parasitol. Res.
104
377-383
2008
Toxoplasma gondii
Boison, D.
The adenosine kinase hypothesis of epileptogenesis
Prog. Neurobiol.
84
249-262
2008
Homo sapiens
Romanello, L.; Bachega, J.F.; Cassago, A.; Brandao-Neto, J.; DeMarco, R.; Garratt, R.C.; Pereira, H.D.
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues
Acta Crystallogr. Sect. D
69
126-136
2013
Schistosoma mansoni
Al Safarjalani, O.N.; Rais, R.H.; Kim, Y.A.; Chu, C.K.; Naguib, F.N.; El Kouni, M.H.
Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities
Biochem. Pharmacol.
80
955-963
2010
Toxoplasma gondii
Cassera, M.B.; Ho, M.C.; Merino, E.F.; Burgos, E.S.; Rinaldo-Matthis, A.; Almo, S.C.; Schramm, V.L.
A high-affinity adenosine kinase from Anopheles gambiae
Biochemistry
50
1885-1893
2011
Anopheles gambiae
Cui, X.; Agarwal, T.; Singh, B.; Gupta, R.
Molecular characterization of chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics
BMC Biochem.
12
22
2011
Rattus norvegicus
Spacilova, P.; Naus, P.; Pohl, R.; Votruba, I.; Snasel, J.; Zabranska, H.; Pichova, I.; Ameral, R.; Birkus, G.; Cihlar, T.; Hocek, M.
CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases
ChemMedChem
5
1386-1396
2010
Homo sapiens, Mycobacterium tuberculosis
Dong, L.; Shi, J.; Wang, J.; Liu, Y.
Theoretical studies on the conformational change of adenosine kinase induced by inhibitors
Int. J. Quantum Chem.
111
3980-3990
2011
Homo sapiens (P55263)
-
Butini, S.; Gemma, S.; Brindisi, M.; Borrelli, G.; Lossani, A.; Ponte, A.M.; Torti, A.; Maga, G.; Marinelli, L.; La Pietra, V.; Fiorini, I.; Lamponi, S.; Campiani, G.; Zisterer, D.M.; Nathwani, S.M.; Sartini, S.; La Motta, C.; Da Settimo, F.; Novellino, E.; Focher, F.
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies
J. Med. Chem.
54
1401-1420
2011
Homo sapiens
Schoor, S.; Farrow, S.; Blaschke, H.; Lee, S.; Perry, G.; von Schwartzenberg, K.; Emery, N.; Moffatt, B.
Adenosine kinase contributes to cytokinin interconversion in Arabidopsis
Plant Physiol.
157
659-672
2011
Arabidopsis thaliana
Kuettel, S.; Greenwald, J.; Kostrewa, D.; Ahmed, S.; Scapozza, L.; Perozzo, R.
Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation
PLoS Negl. Trop. Dis.
5
e1164
2011
Trypanosoma brucei (Q584S0), Trypanosoma brucei
Timm, J.; Gonzalez-Pacanowska, D.; Wilson, K.S.
Structures of adenosine kinase from Trypanosoma brucei brucei
Acta crystallogr. Sect. F
70
34-39
2014
Trypanosoma brucei brucei (Q584S0), Trypanosoma brucei brucei, Trypanosoma brucei brucei 927/4 (Q584S0)
Kar, R.; Ansari, M.; Suryadevara, P.; Sahoo, B.; Sahoo, G.; Dikhit, M.; Das, P.
Computational elucidation of structural basis for ligand binding with Leishmania donovani adenosine kinase
BioMed Res. Int.
2013
609289
2013
Leishmania donovani
Savi, L.; Brindisi, M.; Alfano, G.; Butini, S.; La Pietra, V.; Novellino, E.; Marinelli, L.; Lossani, A.; Focher, F.; Cavella, C.; Campiani, G.; Gemma, S.
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors
Chem. Biol. Drug Des.
87
112-120
2016
Homo sapiens (P55263), Homo sapiens
Malnuit, V.; Slavetinska, L.P.; Naus, P.; Dzubak, P.; Hajduch, M.; Stolarikova, J.; Snasel, J.; Pichova, I.; Hocek, M.
2-substituted 6-(het)aryl-7-deazapurine ribonucleosides: synthesis, inhibition of adenosine kinases, and antimycobacterial activity
ChemMedChem
10
1079-1093
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis My 331/88
Naguib, F.N.; Rais, R.H.; Al Safarjalani, O.N.; el Kouni, M.H.
Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine
Comp. Biochem. Physiol. B
188
63-69
2015
Toxoplasma gondii (Q9TVW2), Toxoplasma gondii
Mori, K.; Hiraoka, O.; Ikeda, M.; Ariumi, Y.; Hiramoto, A.; Wataya, Y.; Kato, N.
Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin
Hepatology
58
1236-1244
2013
Homo sapiens (P55263), Homo sapiens
Li, J.; Jia, B.; Liang, X.; Liu, J.; Wang, Y.; Liang, X.; Yan, H.; Wang, Y.; Zhang, S.
An adenosine kinase in apoplastic location is involved in Magnaporthe oryzae cold acclimation
J. Basic Microbiol.
54
269-277
2014
Pyricularia oryzae (G4N8F5), Pyricularia oryzae, Pyricularia oryzae ATCC MYA-4617 (G4N8F5)
Snasel, J.; Naus, P.; Dostal, J.; Hnizda, A.; Fanfrlik, J.; Brynda, J.; Bourderioux, A.; Dusek, M.; Dvorakova, H.; Stolarikova, J.; Zabranska, H.; Pohl, R.; Konecny, P.; Dzubak, P.; Votruba, I.; Hajduch, M.; Rezacova, P.; Veverka, V.; Hocek, M.; Pichova, I.
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(het)aryl-7-deazaadenine ribonucleosides
J. Med. Chem.
57
8268-8279
2014
Homo sapiens (P55263), Homo sapiens, Mycobacterium tuberculosis (P9WID5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WID5)
Luan, G.; Gao, Q.; Guan, Y.; Zhai, F.; Zhou, J.; Liu, C.; Chen, Y.; Yao, K.; Qi, X.; Li, T.
Upregulation of adenosine kinase in Rasmussen encephalitis
J. Neuropathol. Exp. Neurol.
72
1000-1008
2013
Homo sapiens
Perlikova, P.; Konecny, P.; Naus, P.; Snasel, J.; Votruba, I.; Dzubak, P.; Pichova, I.; Hajduch, M.; Hocek, M.
6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents
MedChemComm
4
1497-1500
2013
Mycobacterium tuberculosis
-
Li, Y.; Wang, Y.; Song, K.; Liu, L.; Cai, R.; Tao, G.; Zhao, P.; Zhou, H.; He, H.
A rapid and sensitive colorimetric assay for the determination of adenosine kinase activity
Biochem. Biophys. Res. Commun.
502
250-254
2018
Bombyx mori (Q2F635), Bombyx mori
Song, K.; Li, Y.; He, H.; Liu, L.; Zhao, P.; Xia, Q.; Wang, Y.
A novel adenosine kinase from Bombyx mori enzymatic activity, structure, and biological function
Int. J. Mol. Sci.
20
3732
2019
Bombyx mori (Q2F635), Bombyx mori
Kimura, H.; Kushima, I.; Yohimi, A.; Aleksic, B.; Ozaki, N.
Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility
Int. J. Neuropsychopharmacol.
21
405-409
2018
Homo sapiens (P55263), Homo sapiens
Toti, K.S.; Osborne, D.; Ciancetta, A.; Boison, D.; Jacobson, K.A.
South (S)- and north (N)-methanocarba-7-deazaadenosine analogues as inhibitors of human adenosine kinase
J. Med. Chem.
59
6860-6877
2016
Homo sapiens (P55263), Homo sapiens
Crespo, R.A.; Dang, Q.; Zhou, N.E.; Guthrie, L.M.; Snavely, T.C.; Dong, W.; Loesch, K.A.; Suzuki, T.; You, L.; Wang, W.; OMalley, T.; Parish, T.; Olsen, D.B.; Sacchettini, J.C.
Structure-guided drug design of 6-substituted adenosine snalogues as potent inhibitors of Mycobacterium tuberculosis adenosine kinase
J. Med. Chem.
62
4483-4499
2019
Homo sapiens (P55263), Homo sapiens, Mycobacterium tuberculosis (P9WID5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WID5)
Fassett, J.; Xu, X.; Kwak, D.; Zhu, G.; Fassett, E.K.; Zhang, P.; Wang, H.; Mayer, B.; Bache, R.J.; Chen, Y.
Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction
J. Mol. Cell. Cardiol.
130
49-58
2019
Mus musculus (P55264)
Xu, Y.; Wang, Y.; Yan, S.; Yang, Q.; Zhou, Y.; Zeng, X.; Liu, Z.; An, X.; Toque, H.A.; Dong, Z.; Jiang, X.; Fulton, D.J.; Weintraub, N.L.; Li, Q.; Bagi, Z.; Hong, M.; Boison, D.; Wu, C.; Huo, Y.
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
Nat. Commun.
8
943
2017
Homo sapiens (P55263)
de Oliveira, R.R.; Morales-Neto, R.; Rocco, S.A.; Sforca, M.L.; Polo, C.C.; Tonoli, C.C.C.; Mercaldi, G.F.; Cordeiro, A.T.; Murakami, M.T.; Franchini, K.G.
Adenosine kinase couples sensing of cellular potassium depletion to purine metabolism
Sci. Rep.
8
11988
2018
Mus musculus (P55264), Mus musculus
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