Activating Compound | Comment | Organism | Structure |
---|---|---|---|
creatine phosphate | 8fold increase in Vmax at 20 mM | Cricetulus griseus | |
additional information | no significant stimulation by O-phosphorylethanolamine, glucose 6-phosphate, D-3-phosphoglyceric acid, phospho-L-serine | Cricetulus griseus | |
phosphate | antagonized by phosphonoacetic acid | Cricetulus griseus | |
phosphoenolpyruvate | 5fold increase in Vmax at 20 mM | Cricetulus griseus | |
Phosphonoformic acid | - |
Cricetulus griseus | |
phosphoribosyl diphosphate | 5fold increase in Vmax at 20 mM | Cricetulus griseus | |
Sodium diphosphate | - |
Cricetulus griseus |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Cricetulus griseus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-carboxyethyl phosphonic acid | - |
Cricetulus griseus | |
N-phosphomethyl glycine | - |
Cricetulus griseus | |
N-phosphomethyl iminodiacetic acid | - |
Cricetulus griseus | |
Phosphonoacetic acid | 64% inhibition at 8 mM, antagonized by phosphate | Cricetulus griseus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 1-10 mM phosphate | Cricetulus griseus | |
0.0017 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 10-20 mM creatine phosphate | Cricetulus griseus | |
0.0022 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoribosyl diphosphate | Cricetulus griseus | |
0.0023 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoenolpyruvate | Cricetulus griseus | |
0.0075 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C | Cricetulus griseus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Cricetulus griseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | Cricetulus griseus | purine salvage enzyme | ADP + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Escherichia coli | Cricetulus griseus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + adenosine = ADP + AMP | catalytic mechanism, substrate and product binding involving Asp239, Glu242, Asp316, and Arg148 | Cricetulus griseus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000066 | - |
purifed recombinant enzyme | Cricetulus griseus |
0.000305 | - |
purifed recombinant enzyme, in presence of 10 mM phosphoribosyl diphosphate | Cricetulus griseus |
0.000365 | - |
purifed recombinant enzyme, in presence of 10 mM phosphoenolpyruvate | Cricetulus griseus |
0.000544 | - |
purifed recombinant enzyme, in presence of 10 mM creatine phosphate | Cricetulus griseus |
0.000888 | - |
purifed recombinant enzyme, in presence of 10 mM phosphate | Cricetulus griseus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosine | - |
Cricetulus griseus | ADP + AMP | - |
? | |
ATP + adenosine | purine salvage enzyme | Cricetulus griseus | ADP + AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AK | - |
Cricetulus griseus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cricetulus griseus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C | Cricetulus griseus | |
0.33 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoribosyl diphosphate | Cricetulus griseus | |
0.4 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM phosphoenolpyruvate | Cricetulus griseus | |
0.59 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 20 mM creatine phosphate | Cricetulus griseus | |
0.97 | - |
adenosine | recombinant enzyme, pH 7.2, 37°C, in presence of 10 mM phosphate | Cricetulus griseus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Cricetulus griseus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.95 | - |
Phosphonoacetic acid | recombinant enzyme, pH 7.2, 37°C | Cricetulus griseus |