Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-difluoro-3-deaza-7-iso-adenosine | 0.1 mM, 18% inhibition | Homo sapiens | |
2,3-difluoro-3-deaza-7-iso-adenosine | 0.1 mM, 4% inhibition | Mycobacterium tuberculosis | |
2,3-difluoro-3-deaza-7-isoadenosine | 0.1 mM, 18% inhibition of phosphorylation of adenosine | Homo sapiens | |
2,3-difluoro-3-deaza-adenosine | 0.1 mM, 12% inhibition | Homo sapiens | |
2,3-difluoro-3-deazaadenosine | 0.1 mM, 12% inhibition of phosphorylation of adenosine | Homo sapiens | |
2-fluoro-3-deaza-adenosine | 0.1 mM, 9% inhibition | Homo sapiens | |
2-fluoro-3-deaza-adenosine | 0.1 mM, 16% inhibition | Mycobacterium tuberculosis | |
2-fluoro-3-deaza-N6-methyl-adenosine | 0.1 mM, 13% inhibition; 0.1 mM, 13% inhibition of phosphorylation of adenosine | Homo sapiens | |
2-fluoro-3-deaza-N6-methyl-adenosine | 0.1 mM, 37% inhibition; 0.1 mM, 37% inhibition of phosphorylation of adenosine | Mycobacterium tuberculosis | |
2-fluoro-3-deazaadenosine | 0.1 mM, 9% inhibition of phosphorylation of adenosine | Homo sapiens | |
2-fluoro-3-deazaadenosine | 0.1 mM, 16% inhibition of phosphorylation of adenosine | Mycobacterium tuberculosis | |
3-chloro-3-deaza-adenosine | 0.1 mM, 9% inhibition | Homo sapiens | |
3-chloro-3-deaza-adenosine | 0.1 mM, 71% inhibition | Mycobacterium tuberculosis | |
3-chloro-3-deazaadenosine | 0.1 mM, 9% inhibition of phosphorylation of adenosine | Homo sapiens | |
3-chloro-3-deazaadenosine | 0.1 mM, 71% inhibition of phosphorylation of adenosine | Mycobacterium tuberculosis | |
3-deaza-adenosine | 0.1 mM, 6% inhibition | Homo sapiens | |
3-deazaadenosine | 0.1 mM, 6% inhibition of phosphorylation of adenosine | Homo sapiens | |
3-fluoro-3-deaza-adenosine | 0.1 mM, 12% inhibition | Homo sapiens | |
3-fluoro-3-deazaadenosine | 0.1 mM, 12% inhibition of phosphorylation of adenosine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.001 | - |
substrate: 2,3-difluoro-3-deaza-7-isoadenosine | Mycobacterium tuberculosis |
0.001 | - |
substrate: 3-deazaadenosine | Mycobacterium tuberculosis |
0.001 | - |
substrate: 3-fluoro-3-deazaadenosine | Homo sapiens |
0.005 | - |
substrate: 2,3-difluoro-3-deaza-7-isoadenosine | Homo sapiens |
0.006 | - |
substrate: 2,3-difluoro-3-deazaadenosine | Homo sapiens |
0.016 | - |
substrate: 3-fluoro-3-deazaadenosine | Mycobacterium tuberculosis |
0.063 | - |
substrate: 2-fluoro-3-deazaadenosine | Mycobacterium tuberculosis |
0.081 | - |
substrate: 2,3-difluoro-3-deazaadenosine | Mycobacterium tuberculosis |
2.7 | - |
substrate: adenosine | Homo sapiens |
3.7 | - |
substrate: adenosine | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine | 0.03% of the activity with adenosine | Mycobacterium tuberculosis | ADP + 2,3-difluoro-3-deaza-7-iso-AMP | - |
? | |
ATP + 2,3-difluoro-3-deaza-7-iso-adenosine | 0.2% of the activity with adenosine | Homo sapiens | ADP + 2,3-difluoro-3-deaza-7-iso-AMP | - |
? | |
ATP + 2,3-difluoro-3-deaza-7-isoadenosine | specific activity1 1 nM/mg/min | Mycobacterium tuberculosis | ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate | - |
? | |
ATP + 2,3-difluoro-3-deaza-7-isoadenosine | specific activity: 5 nM/mg/min | Homo sapiens | ADP + 2,3-difluoro-3-deaza-7-isoadenosine 5'-phosphate | - |
? | |
ATP + 2,3-difluoro-3-deaza-adenosine | 0.2% of the activity with adenosine | Homo sapiens | ADP + 2,3-difluoro-3-deaza-AMP | - |
? | |
ATP + 2,3-difluoro-3-deaza-adenosine | 2.2% of the activity with adenosine | Mycobacterium tuberculosis | ADP + 2,3-difluoro-3-deaza-AMP | - |
? | |
ATP + 2,3-difluoro-3-deazaadenosine | specific activity 81 nM/mg/min | Mycobacterium tuberculosis | ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate | - |
? | |
ATP + 2,3-difluoro-3-deazaadenosine | specific activity: 1 nM/mg/min | Homo sapiens | ADP + 2,3-difluoro-3-deazaadenosine 5'-phosphate | - |
? | |
ATP + 2-fluoro-3-deaza-adenosine | 1.7% of the activity with adenosine | Mycobacterium tuberculosis | ADP + 2-fluoro-3-deaza-AMP | - |
? | |
ATP + 2-fluoro-3-deazaadenosine | specific activity 63 nM/mg/min | Mycobacterium tuberculosis | ADP + 2-fluoro-3-deazaadenosine 5'-phosphate | - |
? | |
ATP + 3-deazaadenosine | specific activity 1 nM/mg/min | Mycobacterium tuberculosis | ADP + 3-deazaadenosine 5'-phosphate | - |
? | |
ATP + 3-deazaadenosine | 0.03% of the activity with adenosine | Mycobacterium tuberculosis | ADP + 3-deaza-AMP | - |
? | |
ATP + 3-fluoro-3-deaza-adenosine | 0.04% of the activity with adenosine | Homo sapiens | ADP + 3-fluoro-3-deaza-AMP | - |
? | |
ATP + 3-fluoro-3-deaza-adenosine | 0.4% of the activity with adenosine | Mycobacterium tuberculosis | ADP + 3-fluoro-3-deaza-AMP | - |
? | |
ATP + 3-fluoro-3-deazaadenosine | specific activity 16 nM/mg/min | Mycobacterium tuberculosis | ADP + 3-fluoro-3-deazaadenosine 5'-phosphate | - |
? | |
ATP + 3-fluoro-3-deazaadenosine | specific activity: 1 nM/mg/min | Homo sapiens | ADP + 3-fluoro-3-deazaadenosine 5'-phosphate | - |
? | |
ATP + adenosine | - |
Homo sapiens | ADP + AMP | - |
? | |
ATP + adenosine | - |
Mycobacterium tuberculosis | ADP + AMP | - |
? | |
ATP + adenosine | specific activity: 2700 nM/mg/min | Homo sapiens | ADP + AMP | - |
? | |
ATP + adenosine | specific activity: 3700 nM/mg/min | Mycobacterium tuberculosis | ADP + AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ado kinase | - |
Homo sapiens |
Ado kinase | - |
Mycobacterium tuberculosis |