Literature summary for 2.7.1.20 extracted from

Park, J.; Vaidyanathan, G.; Singh, B.; Gupta, R.S.
Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase (2007), Protein J., 26, 203-212.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-tert-butyl-4H-benzo[1,2,4]thiadiazine-3-thione	36% inhibition at 0.002 mM, 68% inhibition at 0.004 mM, 83% inhibition at 0.01 mM	Homo sapiens
2-[2-(3,4-dihydroxy-phenyl)-5-phenyl-1H-imidazol-4-yl]-fluoren-9-one	87% inhibition at 0.002 mM, 89% inhibition at 0.004 mM, 96% inhibition at 0.01 mM	Homo sapiens
2-[3-(1H-benzoimidazol-2-yl)-6-methoxy-chromen-2-ylideneamino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amide	20% inhibition at 0.002 mM, 56% inhibition at 0.004 mM, 81% inhibition at 0.01 mM; 20% inhibition at 0.020 mM, 56% inhibition at 0.040 mM, 81% inhibition at 0.1 mM	Homo sapiens
3-[3-(4-hydroxy-phenyl)-4-oxo-2-thioxo-thiazolidin-5-ylidene]-1-methyl-1,3,3a,7a-tetrahydro-indol-2-one	68% at 0.020 mM, 88% inhibition at 0.04 mM, 98% inhibition at 0.1 mM; 68% inhibition at 0.002 mM, 88% inhibition at 0.004 mM, 98% inhibition at 0.01 mM	Homo sapiens
3-[5,6-bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamino]-propan-1-ol	86% inhibition at 0.002 mM, 87% inhibition at 0.004 mM, 89% inhibition at 0.01 mM	Homo sapiens
cyclohexyl-(2-thiophen-2-ylimidazo[1,2-a]pyrazin-3-yl)-amine	40% inhibition at 0.002 mM, 61% inhibition at 0.004 mM, 78% inhibition at 0.01 mM; 40%inhibition at 0.02 mM, 61% inhibition at 0.040 mM, 78% inhibition at 0.1 mM	Homo sapiens
cyclopentyl-(2-thiophen-2-ylimidazo[1,2-a]pyrazin-3-yl)-amine	57% at 0.020 mM, 66% inhibition at 0.04 mM, 73% inhibition at 0.1 mM; 57% inhibition at 0.002 mM, 66% inhibition at 0.004 mM, 73% inhibition at 0.01 mM	Homo sapiens
N-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-yl)-propionamide	40% inhibition at 0.002 mM, 61% inhibition at 0.004 mM, 78% inhibition at 0.01 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + adenosine	-	Homo sapiens	ADP + AMP	-	?

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Release 2023.1 (January 2023)