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Literature summary for 2.7.1.20 extracted from

  • Schoor, S.; Moffatt, B.A.
    Applying high throughput techniques in the study of adenosine kinase in plant metabolism and development (2004), Front. Biosci., 9, 1771-1781.
    View publication on PubMed
Search for more literature for 2.7.1.20

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme expression in increased due to pathogen infection or abiotic stresses Nicotiana tabacum
additional information enzyme expression is increased 2-3fold in reponse to increased methylation activity, e.g. during salt stress and enhanced glycine betaine production Spinacia oleracea
additional information salt stress induces the enzyme as well as the adenosine nucleosidase by 2 and 1.5fold, respectively, the enzyme responses to increased S-adenosyl-L-methionine-dependent methylation activity Avicennia marina
additional information the activity of both isozymes is increased by 1.5-3.5fold in case of increased methylation activity, e.g. during highe cell wall synthesis rates or during xylogenesis Populus sp.
additional information the activity of both isozymes is increased by 1.5-3.5fold in case of increased methylation activity, e.g. during higher cell wall synthesis rates, apoptosis does not influence enzyme levels Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information ADK gene silencing induces the expression of S-adenosyl-L-homocysteine hydrolase resulting in up to 40fold higher S-adenosyl-L-homocysteine levels compared to wild-type plants, completely enzyme-deficient insertion mutants cannot be recovered, while mutants showing less than 10% residual activity are viable with altered phenotypes including small, rounded and wavy leaves and delayed senescence Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
Begomovirus AL2 Begomovirus protein expressed in infected tobacco plants inactivates the adenosine kinase Nicotiana tabacum
Curtovirus L2 Curtovirus protein expressed in infected tobacco plants inactivates the adenosine kinase Nicotiana tabacum
additional information enzyme activity decreases by 5.5fold in senescent cell cultures, apoptosis does not influence enzyme levels Arabidopsis thaliana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Spinacia oleracea
Mg2+
-
 Populus sp.
Mg2+
-
 Nicotiana tabacum
Mg2+
-
 Arabidopsis thaliana
Mg2+
-
 Solanum lycopersicum
Mg2+
-
 Physcomitrium patens
Mg2+
-
 Avicennia marina
Mg2+
-
 Medicago truncatula
additional information divalent cation requirement Spinacia oleracea
additional information divalent cation requirement Populus sp.
additional information divalent cation requirement Nicotiana tabacum
additional information divalent cation requirement Arabidopsis thaliana
additional information divalent cation requirement Solanum lycopersicum
additional information divalent cation requirement Physcomitrium patens
additional information divalent cation requirement Avicennia marina
additional information divalent cation requirement Medicago truncatula

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + adenosine Arabidopsis thaliana the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, housekeeping enzymes, essential for maintainance of S-adenosyl-methionine-dependent transmethylation activities, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Spinacia oleracea the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Populus sp. the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Solanum lycopersicum the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Avicennia marina the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Medicago truncatula the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Nicotiana tabacum the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, part of the defense response against viral infection, metabolic role, overview ADP + AMP
-
 ?
ATP + adenosine Physcomitrium patens the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, the metabolic route also utilizes exogenously fed and incorporated isopentenyladenosine involving the enzyme, metabolic role, overview ADP + AMP
-
 ?
additional information Avicennia marina the organism prefers the minor route of adenosine salvage/recycling via adenosine deaminase, EC 3.5.4.4, and adenosine nucleosidase, EC 3.2.2.9, compared to the major route via adenosine kinase, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 2 isozymes ADK1 and ADK2
-
Avicennia marina
-
-
-
Medicago truncatula
-
-
-
Nicotiana tabacum
-
-
-
Physcomitrium patens
-
 a moss
-
Populus sp.
-
-
-
Solanum lycopersicum
-
 2 isozymes ADK1 and ADK2
-
Spinacia oleracea
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
callus
-
 Arabidopsis thaliana
-
cell culture
-
 Nicotiana tabacum
-
cell culture enzyme activity decreases by 5.5fold in senescent cell cultures, 1.5-3.5fold increased activity of both isozymes during cell wall synthesis Arabidopsis thaliana
-
chloronema
-
 Physcomitrium patens
-
flower bud high expression level of both isozymes Arabidopsis thaliana
-
leaf
-
 Avicennia marina
-
leaf low expression level of both isozymes Arabidopsis thaliana
-
meristem high expression level of both isozymes Arabidopsis thaliana
-
additional information tissue expression level analysis, the isozymes have similar expression patterns, except in case of microgametogenesis, where isozyme ADK1 is upregulated while isozyme ADK2 is not, ADK1 is the major isozyme Arabidopsis thaliana
-
additional information transcript profiling Populus sp.
-
additional information transcript profiling of isozymes ADK1 and ADK2, during desiccation the enzyme expression level remains constant up to 27 days after pollination, then decreases, and peaking again at day 43, then decreases again, overview Solanum lycopersicum
-
additional information transcript profiling, during desiccation the enzyme expression level remains constant up to 18-20 days after pollination, then decreases, overview Medicago truncatula
-
root highest expression level of both isozymes Arabidopsis thaliana
-
seed
-
 Arabidopsis thaliana
-
seed
-
 Solanum lycopersicum
-
seed
-
 Medicago truncatula
-
silique expanding green siliques contain a 4fold higher expression of isozyme ADK1 compared to isozyme ADK2 Arabidopsis thaliana
-
TBY-2 cell
-
 Nicotiana tabacum
-
xylem high enzyme activity Populus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + adenosine
-
 Spinacia oleracea ADP + AMP
-
 ?
ATP + adenosine
-
 Populus sp. ADP + AMP
-
 ?
ATP + adenosine
-
 Nicotiana tabacum ADP + AMP
-
 ?
ATP + adenosine
-
 Arabidopsis thaliana ADP + AMP
-
 ?
ATP + adenosine
-
 Solanum lycopersicum ADP + AMP
-
 ?
ATP + adenosine
-
 Physcomitrium patens ADP + AMP
-
 ?
ATP + adenosine
-
 Avicennia marina ADP + AMP
-
 ?
ATP + adenosine
-
 Medicago truncatula ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, housekeeping enzymes, essential for maintainance of S-adenosyl-methionine-dependent transmethylation activities, metabolic role, overview Arabidopsis thaliana ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview Spinacia oleracea ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview Populus sp. ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview Solanum lycopersicum ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview Avicennia marina ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, metabolic role, overview Medicago truncatula ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, part of the defense response against viral infection, metabolic role, overview Nicotiana tabacum ADP + AMP
-
 ?
ATP + adenosine the enzyme is involved in adenosine and adenine salvage and interconversion of cytokinin ribosides and nucleotides, the metabolic route also utilizes exogenously fed and incorporated isopentenyladenosine involving the enzyme, metabolic role, overview Physcomitrium patens ADP + AMP
-
 ?
additional information the organism prefers the minor route of adenosine salvage/recycling via adenosine deaminase, EC 3.5.4.4, and adenosine nucleosidase, EC 3.2.2.9, compared to the major route via adenosine kinase, overview Avicennia marina ?
-
 ?

Synonyms

Synonyms Comment Organism
ADK
-
 Spinacia oleracea
ADK
-
 Populus sp.
ADK
-
 Nicotiana tabacum
ADK
-
 Arabidopsis thaliana
ADK
-
 Solanum lycopersicum
ADK
-
 Physcomitrium patens
ADK
-
 Avicennia marina
ADK
-
 Medicago truncatula