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Literature summary for 2.7.1.20 extracted from

  • Boyer, S.H.; Ugarkar, B.G.; Solbach, J.; Kopcho, J.; Matelich, M.C.; Ollis, K.; Gomez-Galeno, J.E.; Mendonca, R.; Tsuchiya, M.; Nagahisa, A.; Nakane, M.; Wiesner, J.B.; Erion, M.D.
    Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues (2005), J. Med. Chem., 48, 6430-6441.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-iodo-7-(4'-C-spirocyclopropyl-beta-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidine IC50: 600 nM Homo sapiens
4-amino-5-iodo-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]-pyrimidine IC50: 6 nM Homo sapiens
4-N-(2-methoxyphenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 5.3 nM Homo sapiens
4-N-(3,4-ethylenedioxyphenyl)amino-5-(2-methylphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 1 nM Homo sapiens
4-N-(3,4-ethylenedioxyphenyl)amino-5-phenyl-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 4 nM Homo sapiens
4-N-(3-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine IC50: 2 nM Homo sapiens
4-N-(4-bromophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine IC50: 5 nM Homo sapiens
4-N-(4-cyanophenyl)amino-5-(4-chlorophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 7 nM Homo sapiens
4-N-(4-cyanophenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 2 nM Homo sapiens
4-N-(4-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine IC50: 3 nM Homo sapiens
4-N-(4-fluorophenyl)amino-5-(3-aminophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 10 nM Homo sapiens
4-N-(4-fluorophenyl)amino-5-phenyl-7-(4'-C-spirocyclopropyl-beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 0.3 nM Homo sapiens
4-N-(4-fluorophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine IC50: 6 nM Homo sapiens
4-N-phenylamino-5-phenyl-7-(5'-deoxy-4'-C-methyl-beta-D-ribo-furanosyl)pyrrolo[2,3-d]pyrimidine IC50: 4000 nM Homo sapiens
4-N-phenylamino-5-phenyl-7-(beta-D-erythro-furanosyl)-pyrrolo[2,3-d]pyrimidine IC50: 4 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000003
-
IC50: 0.3 nM Homo sapiens 4-N-(4-fluorophenyl)amino-5-phenyl-7-(4'-C-spirocyclopropyl-beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.000001
-
IC50: 1 nM Homo sapiens 4-N-(3,4-ethylenedioxyphenyl)amino-5-(2-methylphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.000002
-
IC50: 2 nM Homo sapiens 4-N-(3-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
0.000002
-
IC50: 2 nM Homo sapiens 4-N-(4-cyanophenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.000003
-
IC50: 3 nM Homo sapiens 4-N-(4-ethoxyphenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
0.000004
-
IC50: 4 nM Homo sapiens 4-N-phenylamino-5-phenyl-7-(beta-D-erythro-furanosyl)-pyrrolo[2,3-d]pyrimidine
0.000004
-
IC50: 4 nM Homo sapiens 4-N-(3,4-ethylenedioxyphenyl)amino-5-phenyl-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.000005
-
IC50: 5 nM Homo sapiens 4-N-(4-bromophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
0.0000053
-
IC50: 5.3 nM Homo sapiens 4-N-(2-methoxyphenyl)amino-5-(4-ethoxyphenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.000006
-
IC50: 6 nM Homo sapiens 4-amino-5-iodo-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]-pyrimidine
0.000006
-
IC50: 6 nM Homo sapiens 4-N-(4-fluorophenyl)amino-5-phenyl-7-(beta-D-erythrofuranosyl)pyrrolo[2,3-d]pyrimidine
0.000007
-
IC50: 7 nM Homo sapiens 4-N-(4-cyanophenyl)amino-5-(4-chlorophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.00001
-
IC50: 10 nM Homo sapiens 4-N-(4-fluorophenyl)amino-5-(3-aminophenyl)-7-(beta-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
0.0006
-
IC50: 600 nM Homo sapiens 4-amino-5-iodo-7-(4'-C-spirocyclopropyl-beta-D-erythropentofuranosyl)pyrrolo[2,3-d]pyrimidine
0.004
-
IC50: 4000 nM Homo sapiens 4-N-phenylamino-5-phenyl-7-(5'-deoxy-4'-C-methyl-beta-D-ribo-furanosyl)pyrrolo[2,3-d]pyrimidine