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Literature summary for 2.7.1.20 extracted from

  • Al Safarjalani, O.N.; Rais, R.H.; Ah Kim, Y.; Chu, C.K.; Naguib, F.N.; El Kouni, M.H.
    7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities (2008), Biochem. Pharmacol., 76, 958-966.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Toxoplasma gondii adenosine kinase is an excellent target for chemotherapy and 7-deaza-6-benzylthioinosines are potential antitoxoplasmic agents Toxoplasma gondii

Inhibitors

Inhibitors Comment Organism Structure
6-benzylthioinosine
-
Toxoplasma gondii
7-Deazainosine
-
Toxoplasma gondii
additional information all the 7-deaza-6-benzylthioinosine analogues showed a selective antitoxoplasmic effect against wild type parasites, but not mutants lacking adenosine kinase Toxoplasma gondii
pyrimethamine
-
Toxoplasma gondii
Sulfadiazine
-
Toxoplasma gondii

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0161
-
pH 7.5, 37°C Toxoplasma gondii pyrimethamine
0.0161
-
pH 7.5, 37°C Toxoplasma gondii 6-benzylthioinosine
0.0273
-
pH 7.5, 37°C Toxoplasma gondii Sulfadiazine
0.0273
-
pH 7.5, 37°C Toxoplasma gondii 7-Deazainosine