Application | Comment | Organism |
---|---|---|
medicine | Toxoplasma gondii adenosine kinase is an excellent target for chemotherapy and 7-deaza-6-benzylthioinosines are potential antitoxoplasmic agents | Toxoplasma gondii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-benzylthioinosine | - |
Toxoplasma gondii | |
7-Deazainosine | - |
Toxoplasma gondii | |
additional information | all the 7-deaza-6-benzylthioinosine analogues showed a selective antitoxoplasmic effect against wild type parasites, but not mutants lacking adenosine kinase | Toxoplasma gondii | |
pyrimethamine | - |
Toxoplasma gondii | |
Sulfadiazine | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0161 | - |
pH 7.5, 37°C | Toxoplasma gondii | pyrimethamine | |
0.0161 | - |
pH 7.5, 37°C | Toxoplasma gondii | 6-benzylthioinosine | |
0.0273 | - |
pH 7.5, 37°C | Toxoplasma gondii | Sulfadiazine | |
0.0273 | - |
pH 7.5, 37°C | Toxoplasma gondii | 7-Deazainosine |