2.7.7.43: N-acylneuraminate cytidylyltransferase
This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.43
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2.7.7.43
-
sialylation
-
sialyltransferase
-
meningitidis
-
polysialic
-
lipooligosaccharide
-
n-acetylmannosamine
-
ducreyi
-
sialoglycoconjugates
-
synthesis
-
kdn
-
mannac
-
neu5gc
-
medicine
-
agriculture
- 2.7.7.43
-
sialylation
-
sialyltransferase
- meningitidis
-
polysialic
- lipooligosaccharide
- n-acetylmannosamine
- ducreyi
-
sialoglycoconjugates
- synthesis
- kdn
- mannac
- neu5gc
- medicine
- agriculture
Reaction
Synonyms
AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS
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Reference on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kean, E.L.; Roseman, S.
The sialic acids. X. Purification and properties of cytidine 5-monophosphosialic acid synthetase
J. Biol. Chem.
241
5643-5650
1966
Bos taurus, Ovis aries, Homo sapiens, Sus scrofa
Kolisis, F.N.
Studies on acylneuraminate cytidylytransferase from human placenta
Arch. Int. Physiol. Biochim.
92
179-184
1984
Homo sapiens
Haft, R.F.; Wessels, M.R.
Characterization of CMP-N-acetylneuraminic acid synthetase of group B streptococci
J. Bacteriol.
176
7372-7374
1994
Streptococcus sp., Streptococcus sp. Ib
Schmelter, T.; Ivanov, S.; Wember, M.; Stangier, P.; Thiem, J.; Schauer, R.
Partial purification and characterization of cytidine-5-monophosphosialate synthase from rainbow trout liver
Biol. Chem. Hoppe-Seyler
374
337-342
1993
Oncorhynchus mykiss
Edwards, U.; Frosch, M.
Sequence and functional analysis of the cloned Neisseria meningitidis CMP neunac synthetase
FEMS Microbiol. Lett.
96
161-166
1992
Neisseria meningitidis
-
Vann, W.F.; Silver, R.P.; Abeijon, C.; Chang, K.; Aaronson, W.; Sutton, A.; Finn, C.W.; Lindner, W.; Kotsatos, M.
Purification, properties, and genetic location of Escherichia coli cytidine 5-monophosphate N-acetylneuraminic acid synthetase
J. Biol. Chem.
262
17556-17562
1987
Escherichia coli, Escherichia coli O18:K1
Rodriguez-Aparicio, L.B.; Luengo, J.M.; Gonzalez-Clemente, C.; Reglero, A.
Purification and characterization of the nuclear cytidine 5-monophosphate N-acetylneuraminic acid synthetase from rat liver
J. Biol. Chem.
267
9257-9263
1992
Rattus norvegicus
Schauer, R.; Wember, M.
Studies on the substrate specificity of acylneuraminate cytidylyltransferase and sialytransferase of submandibular glands from cow, pig and horse
Hoppe-Seyler's Z. Physiol. Chem.
354
1405-1414
1973
Bos taurus, Equus caballus, Sus scrofa
Schauer, R.; Haverkamp, J.; Ehrlich, K.
Isolation and characterization of acylneuraminate cytidylyltransferase from frog liver
Hoppe-Seyler's Z. Physiol. Chem.
361
641-648
1980
Pelophylax lessonae
Haverkamp, J.; Beau, J.M.; Schauer, R.
Improved synthesis of CMP-sialates using enzymes from frog liver and equine submandibular gland
Hoppe-Seyler's Z. Physiol. Chem.
360
159-166
1979
Equus caballus, Pelophylax lessonae
Corfield, A.P.; Schauer, R.; Wember, M.
The preparation of CMP-sialic acids by using CMP-acylneuraminate synthase from frog liver immobilized on sepharose 4B
Biochem. J.
177
1-7
1979
Pelophylax lessonae
Karwaski, M.F.; Wakarchuk, W.W.; Gilbert, M.
High-level expression of recombinant Neisseria CMP-sialic acid synthetase in Escherichia coli
Protein Expr. Purif.
25
237-240
2002
Neisseria meningitidis (P0A0Z8), Neisseria meningitidis, Neisseria meningitidis 406Y (P0A0Z8)
Vionnet, J.; Concepcion, N.; Warner, T.; Zapata, G.; Hanover, J.; Vann, W.F.
Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands
Glycobiology
9
481-487
1999
Bos taurus
Nakata, D.; Munster, A.K.; Gerardy-Schahn, R.; Aoki, N.; Matsuda, T.; Kitajima, K.
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates
Glycobiology
11
685-692
2001
Oncorhynchus mykiss (Q90WG6), Oncorhynchus mykiss, Mus musculus (Q99KK2), Mus musculus
Revilla-Nuin, B.; Reglero, A.; Feo, J.C.; Rodriguez-Aparicio, L.B.; Ferrero, M.A.
Identification, expression and tissue distribution of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase activity in the rat
Glycoconj. J.
15
233-241
1998
Rattus norvegicus
Kittelmann, M.; Klein, T.; Kragl, U.; Wandrey, C.; Ghisalba, O.
CMP-N-acetyl neuraminic-acid synthetase from Escherichia coli: fermentative production and application for the preparative synthesis of CMP-neuraminic acid
Appl. Microbiol. Biotechnol.
44
59-67
1995
Escherichia coli, Escherichia coli K-235
Haft, R.F.; Wessels, M.R.; Mebane, M.F.; Conaty, N.; Rubens, C.E.
Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli
Mol. Microbiol.
19
555-563
1996
Streptococcus sp.
Bravo, I.G.; Barrallo, S.; Ferrero, M.A.; Rodriguez-Aparicio, L.B.; Martinez-Blanco, H.; Reglero, A.
Kinetic properties of the acylneuraminate cytidylyltransferase from Pasteurella haemolytica A2
Biochem. J.
358
585-598
2001
Mannheimia haemolytica, Mannheimia haemolytica A2
Munster, A.K.; Eckhardt, M.; Potvin, B.; Muhlenhoff, M.; Stanley, P.; Gerardy-Schahn, R.
Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs
Proc. Natl. Acad. Sci. USA
95
9140-9145
1998
Mus musculus (Q99KK2), Mus musculus
Tullius, M.V.; Munson, R.S., Jr.; Wang, J.; Gibson, B.W.
Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi
J. Biol. Chem.
271
15373-15380
1996
[Haemophilus] ducreyi, [Haemophilus] ducreyi 35000
Potvin, B.; Raju, T.S.; Stanley, P.
Lec32 is a new mutation in Chinese hamster ovary cells that essentially abrogates CMP-N-acetylneuraminic acid synthetase activity
J. Biol. Chem.
270
30415-30421
1995
Cricetulus griseus
Gilbert, M.; Watson, D.C.; Wakarchuk, W.W.
Purification and characterization of the recombinant CMP-sialic acid synthetase from Neisseria meningitidis
Biotechnol. Lett.
19
417-420
1997
Neisseria meningitidis (P0A0Z8), Neisseria meningitidis 406Y (P0A0Z8)
-
Samuels, N.M.; Gibson, B.W.; Miller, S.M.
Investigation of the kinetic mechanism of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi with new insights on rate-limiting steps from product inhibition analysis
Biochemistry
38
6195-6203
1999
[Haemophilus] ducreyi
Mosimann, S.C.; Gilbert, M.; Dombroswki, D.; To, R.; Wakarchuk, W.; Strynadka, N.C.
Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP
J. Biol. Chem.
276
8190-8196
2001
Neisseria meningitidis (P0A0Z8), Neisseria meningitidis
Knorst, M.; Fessner, W.D.
CMP-sialate synthetase from Neisseria meningitidis - overexpression and application to the synthesis of oligosaccharides containing modified sialic acids
Adv. Synth. Catal.
343
698-710
2001
Neisseria meningitidis
-
Bravo, I.G.; Reglero, A.
The cytidylyltransferases family: properties, kinetics, genomic and phylogeny: The cytidylyltransferases family: properties, kinetics, genomic and phylogeny
Recent Res. Devel. Biochem.
4
223-254
2003
Bos taurus, Cricetinae, Equus caballus, Erinaceidae, Escherichia coli, Homo sapiens, Mannheimia haemolytica, Neisseria meningitidis, Oncorhynchus mykiss, Rattus norvegicus, Streptococcus agalactiae, Sus scrofa, [Haemophilus] ducreyi
-
Fujita, A.; Sato, C.; Munster-Kuhnel, A.K.; Gerardy-Schahn, R.; Kitajima, K.
Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system
Anal. Biochem.
337
12-21
2005
Mus musculus, Oncorhynchus mykiss
Yu, H.; Karpel, R.; Chen, X.
Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases
Bioorg. Med. Chem.
12
6427-6435
2004
Neisseria meningitidis
Liu, G.; Jin, C.
CMP-N-acetylneuraminic acid synthetase from Escherichia coli K1 is a bifunctional enzyme: identification of minimal catalytic domain for synthetase activity and novel functional domain for platelet-activating factor acetylhydrolase activity
J. Biol. Chem.
279
17738-17749
2004
Escherichia coli, Escherichia coli K1
Feo-Manga, J.C.; Rodriguez-Aparicio, L.B.; Ferrero, M.A.; Reglero, A.
Purification and partial characterization of CMP-Neu5Ac synthetase from rat brain
Anal. Chim. Acta
564
141-150
2006
Rattus norvegicus
-
Mizanur, R.M.; Pohl, N.L.
Cloning and characterization of a heat-stable CMP-N-acylneuraminic acid synthetase from Clostridium thermocellum
Appl. Microbiol. Biotechnol.
76
827-834
2007
Acetivibrio thermocellus, Acetivibrio thermocellus ATCC 27405
Misaki, R.; Fujiyama, K.; Seki, T.
Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell
Biochem. Biophys. Res. Commun.
339
1184-1189
2006
Homo sapiens
Fujita, A.; Sato, C.; Kitajima, K.
Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase
Biochem. Biophys. Res. Commun.
355
174-180
2007
Mus musculus (Q99KK2), Mus musculus
Yu, H.; Ryan, W.; Yu, H.; Chen, X.
Characterization of a bifunctional cytidine 5-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae
Biotechnol. Lett.
28
107-113
2006
Streptococcus agalactiae (Q9AFG9), Streptococcus agalactiae
Viswanathan, K.; Tomiya, N.; Park, J.; Singh, S.; Lee, Y.C.; Palter, K.; Betenbaugh, M.J.
Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes
J. Biol. Chem.
281
15929-15940
2006
Drosophila melanogaster
Mizanur, R.M.; Pohl, N.L.
Bacterial CMP-sialic acid synthetases: production, properties, and applications
Appl. Microbiol. Biotechnol.
80
757-765
2008
Acetivibrio thermocellus, Escherichia coli, [Haemophilus] ducreyi, Mannheimia haemolytica, Neisseria meningitidis, Escherichia coli K-235, Mannheimia haemolytica A2
Yu, C.C.; Lin, P.C.; Lin, C.C.
Site-specific immobilization of CMP-sialic acid synthetase on magnetic nanoparticles and its use in the synthesis of CMP-sialic acid
Chem. Commun. (Camb. )
21
1308-1310
2008
Neisseria meningitidis
Tiralongo, J.; Fujita, A.; Sato, C.; Kitajima, K.; Lehmann, F.; Oschlies, M.; Gerardy-Schahn, R.; Muenster-Kuehnel, A.K.
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme
Glycobiology
17
945-954
2007
Oncorhynchus mykiss (Q90WG6), Oncorhynchus mykiss
Oschlies, M.; Dickmanns, A.; Haselhorst, T.; Schaper, W.; Stummeyer, K.; Tiralongo, J.; Weinhold, B.; Gerardy-Schahn, R.; von Itzstein, M.; Ficner, R.; Muenster-Kuehnel, A.K.
A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme
J. Mol. Biol.
393
83-97
2009
Mus musculus (Q99KK2), Mus musculus
Wong, J.H.; Sahni, U.; Li, Y.; Chen, X.; Gervay-Hague, J.
Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors
Org. Biomol. Chem.
7
27-29
2009
Neisseria meningitidis
Li, Y.; Yu, H.; Cao, H.; Muthana, S.; Chen, X.
Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity
Appl. Microbiol. Biotechnol.
93
2411-2423
2012
[Haemophilus] ducreyi, Neisseria meningitidis, Pasteurella multocida, Pasteurella multocida ATCC 15742
Kajiwara, H.; Mine, T.; Miyazaki, T.; Yamamoto, T.
A CMP-N-acetylneuraminic acid synthetase purified from a marine bacterium, Photobacterium leiognathi JT-SHIZ-145
Biosci. Biotechnol. Biochem.
75
47-53
2011
Photobacterium leiognathi, Photobacterium leiognathi JT-SHIZ-145
Horsfall, L.E.; Nelson, A.; Berry, A.
Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis
FEBS J.
277
2779-2790
2010
Neisseria meningitidis (P0A0Z8), Neisseria meningitidis
Schaper, W.; Bentrop, J.; Ustinova, J.; Blume, L.; Kats, E.; Tiralongo, J.; Weinhold, B.; Bastmeyer, M.; Muenster-Kuehnel, A.K.
Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio
J. Biol. Chem.
287
13239-13248
2012
Danio rerio (H9BFW7), Danio rerio (Q0E671), Danio rerio
Bose, S.; Purkait, D.; Joseph, D.; Nayak, V.; Subramanian, R.
Structural and functional characterization of CMP-N-acetylneuraminate synthetase from Vibrio cholerae
Acta Crystallogr. Sect. D
75
564-577
2019
Vibrio cholerae
Mertsalov, I.B.; Novikov, B.N.; Scott, H.; Dangott, L.; Panin, V.M.
Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties
Biochem. J.
473
1905-1916
2016
Drosophila melanogaster (Q8IQV0), Drosophila melanogaster
Matthews, M.M.; McArthur, J.B.; Li, Y.; Yu, H.; Chen, X.; Fisher, A.J.
Catalytic cycle of Neisseria meningitidis CMP-sialic acid synthetase illustrated by high-resolution protein crystallography
Biochemistry
59
3157-3168
2020
Neisseria meningitidis (P0A0Z8), Neisseria meningitidis
Abeln, M.; Borst, K.M.; Cajic, S.; Thiesler, H.; Kats, E.; Albers, I.; Kuhn, M.; Kaever, V.; Rapp, E.; Muenster-Kuehnel, A.; Weinhold, B.
Sialylation is dispensable for early murine embryonic development in vitro
ChemBioChem
18
1305-1316
2017
Mus musculus (Q99KK2), Mus musculus
Di, W.; Fujita, A.; Hamaguchi, K.; Delannoy, P.; Sato, C.; Kitajima, K.
Diverse subcellular localizations of the insect CMP-sialic acid synthetases
Glycobiology
27
329-341
2017
Aedes aegypti, Aedes aegypti (Q0IG96), Tribolium castaneum, Tribolium castaneum (A0A2Z5TXA4), Mus musculus (A0A0R4J0B4), Drosophila melanogaster (Q8IQV0), Drosophila melanogaster
Urbanek, K.; Sutherland, D.M.; Orchard, R.C.; Wilen, C.B.; Knowlton, J.J.; Aravamudhan, P.; Taylor, G.M.; Virgin, H.W.; Dermody, T.S.
Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection
J. Virol.
95
e01571-20
2020
Mus musculus (Q99KK2), Mus musculus
Ma, Y.; Tian, S.; Wang, Z.; Wang, C.; Chen, X.; Li, W.; Yang, Y.; He, S.
CMP-N-acetylneuraminic acid synthetase interacts with fragile X related protein 1
Mol. Med. Rep.
14
1501-1508
2016
Homo sapiens (Q8NFW8)
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