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2.7.7.43: N-acylneuraminate cytidylyltransferase

This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.43

Reaction

CTP
+
N-acetylneuraminate
=
diphosphate
 +
CMP-N-acylneuraminate

Synonyms

AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.43 N-acylneuraminate cytidylyltransferase

Inhibitors

Inhibitors on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
1.0 M, 83% inhibition, reversible by desalting
2'-deoxy-CTP
-
0.3 mM; 44% inhibition
2-deoxy-2,3-dehydro-N-acetylneuraminate
-
4.6 mM, 33% inhibition
2-deoxy-2,3-dehydro-N-acetylneuraminic acid
-
4-(hydroxymercuri) benzoic acid
-
-
4-(hydroxymercuri)benzoic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5-Mercuri-CTP
-
-
5-mercury-CTP
-
-
ATP
-
10 mM, 60% inhibition
Ba2+
-
20 mM, less than 30% inhibition
Cd2+
-
inhibits when incubated in presence of Mg2+ at the same concentration
CMP-N-acylneuraminate
cytidine
-
60 mM, 37% inhibition
diphosphate
DTT
-
in the presence of 0.01 M DTT enzyme shows 20% activity loss
GMP
-
20 mM, 64% inhibition
iodoacetate
-
-
N-ethylmaleimide
-
-
NaF
-
in the presence of 0.06 M NaF enzyme shows 17% activity loss
NaN3
-
5 mM, 70% inhibition
Ni2+
-
20 mM in presence of 10 mM Mg2+, more than 90% inhibition
p-hydroxymercuribenzoic acid
-
-
periodate-oxidized CTP
-
-
-
PHMB
-
1 mM, complete inhibition
saturated sulfo-CDP
-
1 mM, 37°C, pH 8.5, 15 min, 55% inhibition
saturated sulfo-UDP
-
1 mM, 37°C, pH 8.5, 15 min, 35% inhibition
saturated sulfo-UDP ester
-
1 mM, 37°C, pH 8.5, 15 min, 24% inhibition
Sr2+
-
20 mM, less than 30% inhibition
sulfo-CDP
-
1 mM, 37°C, pH 8.5, 15 min, 47% inhibition
sulfo-CTP
-
1 mM, 37°C, pH 8.5, 15 min, 39% inhibition
sulfo-UDP
-
1 mM, 37°C, pH 8.5, 15 min, 6% inhibition
sulfo-UTP
-
1 mM, 37°C, pH 8.5, 15 min, 33% inhibition
TTP
-
10 mM in presence of 3 mM CTP, 71% inhibition
UDP-N-acetylglucosamine
-
10 mM, 26% inhibition
UTP
-
10 mM in presence of 3 mM CTP, 75% inhibition
additional information
-