2.7.7.43: N-acylneuraminate cytidylyltransferase

This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.

Reaction

Synonyms

AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.43 N-acylneuraminate cytidylyltransferase

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Results	in table
13	Activating Compound
3864	AA Sequence
8	Application
1	CAS Registry Number
35	Cloned(Commentary)
4	Crystallization (Commentary)
14	Disease/ Diagnostics
1	Expression
12	General Information
9	General Stability
10	IC50 Value
100	Inhibitors
30	kcat/KM [mM/s]
2	Ki Value [mM]
129	KM Value [mM]
30	Localization
64	Metals/Ions
43	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
121	Organism
7	Pathway
17	PDB ID
28	pH Optimum
12	pH Range
3	pH Stability
5	pI Value
8	Posttranslational Modification
53	Protein Variants
26	Purification (Commentary)
6	Reaction
3	Reaction Type
95	Reference
65	Source Tissue
20	Specific Activity [micromol/min/mg]
13	Storage Stability
228	Substrates and Products (Substrate)
39	Subunits
139	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
6	Temperature Range [°C]
16	Temperature Stability [°C]
44	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

the structure of the C-terminal domain of CMP-sialic acid synthetase is solved to 1.9 A resolution

Mus musculus

Q99KK2

705163

ligand-free and sialic acid-bound enzyme, sitting drop vapor diffusion method, using 0.16 M calcium acetate, 0.08 M sodium cacodylate pH 6.5, 14.4% (w/v) PEG 8000, and 20% (v/v) glycerol. Enzyme in complex with Ca2+ and CTP, sitting drop vapor diffusion method, using 0.1 M imidazole pH 8.0, 6% (w/v) PEG 8000, and 0.2 M calcium acetate

Neisseria meningitidis

P0A0Z8

760608

modeling of the closed conformation. Enzyme forms a dimer complex. Amino acids involved in the Neu5Ac binding pocket are Glu162 and Arg165 from monomer B and Gln104, Ser82, Val86, Tyr179, and Phe192 from monomer A

Neisseria meningitidis

-

721380

apoenzyme, hanging drop vapor diffusion method, using 200 mM calcium acetate, 0.1 M imidazole pH 8.0, 10% (w/v) PEG 8000

Vibrio cholerae

-

760285