2.7.7.43: N-acylneuraminate cytidylyltransferase
This is an abbreviated version!
For detailed information about N-acylneuraminate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.43
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2.7.7.43
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sialylation
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sialyltransferase
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meningitidis
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polysialic
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lipooligosaccharide
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n-acetylmannosamine
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ducreyi
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sialoglycoconjugates
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synthesis
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kdn
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mannac
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neu5gc
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medicine
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agriculture
- 2.7.7.43
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sialylation
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sialyltransferase
- meningitidis
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polysialic
- lipooligosaccharide
- n-acetylmannosamine
- ducreyi
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sialoglycoconjugates
- synthesis
- kdn
- mannac
- neu5gc
- medicine
- agriculture
Reaction
Synonyms
AaCSS, acylneuraminate cytidyltransferase, CMAS, Cmas1, Cmas2, CMP sialate pyrophosphorylase, CMP-N-acetylneuraminate synthase, CMP-N-acetylneuraminate synthetase, CMP-N-acetylneuraminic acid synthase, CMP-N-acetylneuraminic acid synthetase, CMP-N-acylneuraminic acid synthetase, CMP-NANA synthetase, CMP-Neu5Ac synthetase, CMP-NeuAc synthetase, CMP-NeuNAc synthetase, CMP-SA synthase, CMP-Sia synthetase, CMP-Sia-syn, CMP-sialate synthase, CMP-sialate synthetase, CMP-sialic acid synthetase, CMP-sialic acid synthetase (CSS), CMP-sialic synthetase, CMPsialate pyrophosphorylase, CMPsialate synthase, CNS, CSAS, CSS, cytidine 5'-monophosphate N-acetylneuraminic acid synthetase, cytidine 5'-monophospho-N-acetylneuraminic acid synthetase, cytidine 5'-monophosphosialic acid synthetase, cytidine 5-monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophosphate sialic acid synthetase, cytidine monophosphate-N-acetylneuraminic acid synthetase, cytidine monophosphate-sialic acid synthetase, cytidine monophospho-sialic acid synthetase, cytidine monophosphoacetylneuraminic synthetase, cytidine monophosphosialate pyrophosphorylase, cytidine monophosphosialate synthetase, cytidyltransferase, acylneuraminate, cytidylyltransferase, acetylneuraminate, DmCSAS, DmCSS, hCSS, mCSS, N-Acetyl-neuraminic acid cytidylyltransferase, NmCSS, SaV CSS, sialate cytidylyltransferase, sialic acid cytidylyltransferase, TcCSS
ECTree
2.7.7.43 N-acylneuraminate cytidylyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.7.43 - N-acylneuraminate cytidylyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + N-acetylneuraminic acid
diphosphate + CMP-N-acetylneuraminic acid
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-
-
?
CTP + N-glycolneuraminate
diphosphate + CMP-N-glycolneuraminate
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N-glycolneuraminate is a relatively weaker substrate than N-acylneuraminate
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the product of the reaction CMP-N-acylneuraminate is the substrate for the sialylation of glycoconjugates by sialyltransferases
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the lec32 mutation reduces CMP-NeuAc synthetase activity to undetectable levels and reduces Neu-Ac on glycoproteins and glycolipids by 95%
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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CMP-NeuAc is essential for the formation of capsule polysialylate for strain K1
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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neuroinvasive and septicaemia-causing pathogens often display a polysialic acid capsule that is involved in invasive behaviour. N-Acetylneuraminate is the basic monomer of polysialic acid. The activated form CMP-N-acylneuraminate is synthesized by N-acylneuraminate cytidylyltransferase
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
production of CMP-N-acetylneuraminate is required for the synthesis of sialylated glycoconjugates
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
the enzyme is involved in the production of activated sialic acids
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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changes in the level of sialylation during development are intimately related to variations in the expression of the enzyme, at least in brain, heart, kidney, stomach, intestine and lung
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the enzyme is involved in synthesis of capsular polysaccharide, the recombinant enzyme can function in K1 capsular polysaccharide biosynthesis in Escherichia coli
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the enzyme is essential in capsular polysaccharide biosynthesis, activates N-acetylneuraminate for transfer to the nascent capsular polysaccharide
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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-
-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
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the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
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-
?
CTP + N-acylneuraminate
diphosphate + CMP-N-acylneuraminate
[Haemophilus] ducreyi 35000
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the enzyme produces CMP-N-acetylneuraminate, the nucleotide sugar donor used by sialyltransferase
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-
?
