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2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Word Map on EC 2.5.1.61

Reaction

4 porphobilinogen +

H2O
=
Hydroxymethylbilane
 + 4 NH3

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.61 hydroxymethylbilane synthase

Molecular Weight

Molecular Weight on EC 2.5.1.61 - hydroxymethylbilane synthase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000
-
gel filtration
31000
-
gel filtration
33000
34000
-
1 * 34000, calculation from crystal structure, asymmetric unit
34268
-
1 * 34268, calculation from sequence of amino acid
35000
35000 - 36000
-
gel filtration
35500
-
gel filtration
36000
36927
-
1 * 36927, calculation from sequence of cDNA
37000
-
1 * 37000, SDS-PAGE, A and B form
38000
39000
-
sucrose density gradient centrifugation
39100
-
1 * 39100, SDS-PAGE
39500
-
1 * 39500, SDS-PAGE, B2 and B3
40000
40500
erythroid enzyme, SDS-PAGE
41000
41200
-
1 * 41200, SDS-PAGE, erythrocyte enzyme
42000
43000
44000
45000
53000
GST-tagged recombinant p.Ala226ProfsX28, removing the GST tag produces a strongly degraded enzyme
68000