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Literature summary for 2.5.1.61 extracted from

  • Lannfelt, L.; Wetterberg, L.; Lilius, L.; Thunell, S.; Joernvall, H.; Pavlu, B.; Wielburski, A.; Gellerfors, P.
    Porphobilinogen deaminase in human erythrocytes (1989), Scand. J. Clin. Lab. Invest., 49, 677-684.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
1 * 40000, SDS-PAGE Homo sapiens
42000
-
1 * 42000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens third enzyme in the heme biosynthetic pathway ?
-
?
porphobilinogen Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2 forms Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblast
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens
0.00117
-
-
Homo sapiens
0.0128
-
40 kDa enzyme form Homo sapiens
0.0183
-
42 kDa enzyme form Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Homo sapiens uroporphyrinogen III + 4 NH3
-
?
4 porphobilinogen + H2O
-
Homo sapiens hydroxylmethylbilane + 4 NH3
-
?
additional information third enzyme in the heme biosynthetic pathway Homo sapiens ?
-
?
porphobilinogen
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 40000, SDS-PAGE Homo sapiens
monomer 1 * 42000, SDS-PAGE Homo sapiens
More the two enzyme forms can each be separated into three differently charged subforms by Mono Q chromatography Homo sapiens

Synonyms

Synonyms Comment Organism
HMB-S
-
Homo sapiens
PBGD
-
Homo sapiens
porphobilinogen deaminase
-
Homo sapiens