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Literature summary for 2.5.1.61 extracted from

  • Meissner, P.; Adams, P.; Kirsch, R.
    Allosteric inhibition of human lymphoblast and purified porphobilinogen deaminase by protoporphyrinogen and coproporphyrinogen (1993), J. Clin. Invest., 91, 1436-1444.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Coproporphyrinogen
-
Homo sapiens
protoporphyrinogen inhibits both erythroid and lymphoblast forms of the enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0081
-
porphobilinogen lymphoblast enzyme from control subjects Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41200
-
1 * 41200, SDS-PAGE, erythrocyte enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
porphobilinogen Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblast variegate porphyria lymphoblasts Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
enzyme activity in lymphoblasts from variegate porphyria subjects Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Homo sapiens uroporphyrinogen III + 4 NH3
-
?
4 porphobilinogen + H2O
-
Homo sapiens hydroxylmethylbilane + 4 NH3
-
?
porphobilinogen
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 41200, SDS-PAGE, erythrocyte enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
PBG-deaminase
-
Homo sapiens
uroporphyrinogen I synthetase
-
Homo sapiens