2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Word Map on EC 2.5.1.61

2.5.1.61

porphyria

intermittent

heme

aip

erythrocyte

delta-aminolevulinic

5-aminolevulinic

gapdh

erythroid

genorm

urinary

dehydratase

protoporphyrin

ferrochelatase

normfinder

housekeeping

tetrapyrrole

bestkeeper

coproporphyrinogen

neurovisceral

ywhaz

protoporphyrinogen

pyrrole

variegate

photodynamic

erythroid-specific

half-normal

porphyrinogenic

coproporphyria

hematin

proto

tarda

pharmacology

beta-2-microglobulin

hyponatremia

diagnostics

gata-1

medicine

rpl13a

lightcycler

cutanea

beta-globin

non-erythroid

reffinder

Reaction

4 porphobilinogen +

+ 4 NH3

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.61 hydroxymethylbilane synthase

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Results	in table
39084	AA Sequence
9	Application
2	CAS Registry Number
21	Cloned(Commentary)
11	Cofactor
8	Crystallization (Commentary)
2136	Disease/ Diagnostics
3	Expression
23	General Information
3	General Stability
94	Inhibitors
40	KM Value [mM]
10	Localization
45	Molecular Weight [Da]
104	Natural Substrates/ Products (Substrates)
272	Organism
1	Oxidation Stability
8	Pathway
32	PDB ID
28	pH Optimum
18	pH Range
1	pH Stability
92	Protein Variants
34	Purification (Commentary)
7	Reaction
1	Reaction Type
99	Reference
47	Source Tissue
43	Specific Activity [micromol/min/mg]
13	Storage Stability
256	Substrates and Products (Substrate)
34	Subunits
157	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
16	Temperature Stability [°C]
1	Turnover Number [1/s]

Organism

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Organism on EC 2.5.1.61 - hydroxymethylbilane synthase

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putative

UniProt

Cereibacter sphaeroides

3 entries

Cereibacter sphaeroides NCIB 8253

N.C.I.B. 8253

5885, 489923

Chlorella regularis

2 entries

Chlorella regularis S-50

S-50

489929

Desulfovibrio vulgaris

sulfate-reducing bacterium

TG1

489928, 489931, 489943, 489951

Felis catus

wild type siblings of mutant cats or unrelated wild type cats, porphyric mutant cats type Saskatchewan (c.189dupT = trunkated (premature stop codon 65) L64S), type Massachusetts (c842_844delGAG = delGly281), type Missouris (c.445C>T = R149W), type OregonAR (c250G>A = A84T)

703965

D3W810, D3W811, D3W812

UniProt

soya-bean

pea

Plasmodium falciparum

UniProt

gene hemC

UniProt

Priestia megaterium ATCC 12872

gene hemC

737348, 737372

D5DT75

UniProt

Propionibacterium freudenreichii subsp. shermanii

489928

Rattus norvegicus

6 entries

Rattus norvegicus Sprague-Dawley

Sprague-Dawley

489934

Saccharomyces cerevisiae

2 entries

Spinacia oleracea

spinach

489921, 489923, 489925, 489929, 489938, 489951

Tetradesmus obliquus

wild-type D3, Sammlung von Algenkulturen, Pflanzenphysiologisches Institiut Universitt Gttingen, Germany

489951

Triticum aestivum

wheat

489923, 489929, 489930

Zea mays

maize

710016