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2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Word Map on EC 2.5.1.61

Reaction

4 porphobilinogen +

H2O
=
Hydroxymethylbilane
 + 4 NH3

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.61 hydroxymethylbilane synthase

Inhibitors

Inhibitors on EC 2.5.1.61 - hydroxymethylbilane synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-bromoporphobilinogen
-
-
2-methylopsopyrroledicarboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
5 mM, pH 8.0, 50% inhibition
Ag2+
-
1 mM AgCl2, 90% inhibition
Coproporphyrinogen
-
-
Cr3+
-
strong
glycerol
-
15% inhibits 40% of enzyme activity
hydroxylamine
isoporphobilinogen
-
-
K+
-
at high concentrations
methoxyamine
-
-
N-ethylmaleimide
NaBH4
-
partially inactivates
opsopyrroledicarboxylic acid
p-chloromercuribenzoate
p-hydroxymercuribenzoate
Pb(NO3)2
-
0.005 mM, 35% inhibition
Pb2+
-
strong
protoporphyrin IX
-
enzyme activity decreases with increasing concentrations, reaching a 33% inhibition at the vivo concentration of porphyrin, 0.00185 mM, and 0.014 mM porphobilinogen
protoporphyrinogen
-
inhibits both erythroid and lymphoblast forms of the enzyme
pyridoxal 5'-phosphate
-
partially inactivates
additional information
-