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Literature summary for 2.5.1.61 extracted from
- Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics (1981), Biochem. J., 193, 301-310.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41000 | - |
gel filtration | Euglena gracilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Euglena gracilis | in presence of a second enzyme, EC 4.2.1.75, uroporphyrinogen-III synthase, often called co-synthase, the product is cyclized to form uroporphyrinogen-III | ? | - |
? |  |
| porphobilinogen | Euglena gracilis | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Euglena gracilis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Euglena gracilis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.1 | - |
- |
Euglena gracilis |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0-4°C, less than 5% loss of activity over 10 days | Euglena gracilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Euglena gracilis | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | stoichiometry of enzyme reaction | Euglena gracilis | hydroxylmethylbilane + 4 NH3 | - |
? | |
| additional information | in presence of a second enzyme, EC 4.2.1.75, uroporphyrinogen-III synthase, often called co-synthase, the product is cyclized to form uroporphyrinogen-III | Euglena gracilis | ? | - |
? | |
| porphobilinogen | - |
Euglena gracilis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| porphobilinogen deaminase | - |
Euglena gracilis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
stoichiometry and kinetic mechanism of the enzyme reaction at different pH values | Euglena gracilis |
| 6 | 9 | pH 6.0: 40% of maximal activity, pH 9.0: 35% of maximal activity | Euglena gracilis |
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