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thymidine phosphorylase mRNA levels are low and statistically not different in whole basal cell carcinoma cells and normal skin and are strongly downregulated in laser capture microdissected-basal cell carcinoma cells as compared with laser capture microdissected-normal epidermis
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higher PyNpase levels in tumor tissue than in normal tissue or tissue adjacent to the tumor, PyNpase levels independent of age, gender, history of recurrence, multiplicity, tumor size, tumor shape, pathological stage (Ta, T1-4), PyNpase levels differ between histological stages being highest in G3, and between papillary versus non-papillary growth pattern, higher PyPnase levels in high-risk group (G3 or Tis or T2) than in low-risk group (primary, single, G1 and Ta)
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presurgery serum from 47 patients with ovarian cancer, and control serum from women with normal ovaries, treated surgically due to nononcological reasons. Significant higher enzyme activity in malignant serum specimen from ovarian cancer patients when compared to the control
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thymidine phosphorylase shows a characteristic pattern of distribution dependent on the phase of the menstrual cycle: enzyme expression moves from stroma to epithelium as the cycle progresses34 and is inversely correlated with estradiol concentrations
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patients with PD-ECGF/TP-positive tumors have a poorer prognosis than those with negative tumors
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T3 and T4
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high expression
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epidermoid
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cholangiocarcinoma-derived cell line, which has a naturally high level of endogenous thymidine phosphorylase
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low activity
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from peripheral blood
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the cytoplasmic level of heterogeneous nuclear ribonucleoprotein K is significantly correlated with the elevated expression of thymidine phosphorylase, and high levels of both proteins are predictive of a poor prognosis in nasopharyngeal carcinoma
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cortical
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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malignant tissue
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tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control
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tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control
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shows significantly greater activity in cancer tissues than in normal tissues
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higher PyNpase levels in normal tissue adjacent to tumor, AN, than in normal tissue, N
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very high expression level
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tumor specimen
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ductal carcinoma in situ and invasive elements
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diverse cancer types, overview
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the enzyme is upregulated in many solid tumors
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the enzyme is highly upregulated in a variety of solid tumours
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WiDR, HT29 and Lovo
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patients with PD-ECGF/TP-positive tumors have a poorer prognosis than those with negative tumors
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enzyme activity is higher in cancer tiddue than in adjacent normal tissue
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tumor
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enzyme activity is higher in cancer tiddue than in adjacent normal tissue
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poorly differentiated adenocarcinoma
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peripheral blood
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no differences in thymidine phosphorylase activity between man and women or with increasing age
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thymidine phosphorylase activity in normal liver tissue adjacent to hepatocellular carcinoma is related to tumor occurrence and may predict postoperative tumor recurrence. Patients who have a high thymidine phosphorylase level in normal liver tissue have significantly earlier recurrence compared with patients who have a low thymidine phosphorylase level. Patients who have a low thymidine phosphorylase level in adjacent liver tissue have a 0.387fold higher risk of postoperative recurrence compared with patients who have a high TP level
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the liver is the major site of pyrimidine metabolism and contains high levels of thymidine phosphorylase (TP)
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normal tissue
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low activity
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the mean thymidine phosphorylase concentration in non-small cell lung cancer tissue is statistically higher than that of normal lung tissue
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SD
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very high expression level
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the mean thymidine phosphorylase concentration in non-small cell lung cancer tissue is statistically higher than that of normal lung tissue
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similar distribution of thymidine phosphorylase and thymidine kinase, EC 2.7.1.21, immunohistochemical analysis, overview
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the enzyme is strongly induced in the serum-deprived nasopharyngeal carcinoma cells, the serum deprivation-triggered upregulation of the enzyme is due to mRNA stabilization, not protein stabilization or transcriptional activation requiring the mRNA CU-rich element sequence and heterogeneous nuclear ribonucleoprotein K, overview
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and adjacent nonmalignant pancreatic tissue
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high expression level, two alternative enzyme forms, a 27 kDa splice variant and another form containing five additional amino acids on the N-terminus, the second form is processed at Thr6 instead of Ala11
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T3
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ulcer
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tumor tissue
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surrounding cancer nests or along the invasive margin of cancer
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fibroblast-like synoviocyte
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rheumatoid athritis-associated
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HUVEC
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normal and tumor tissue
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leiomyoma
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additional information
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no activity in normal brain
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additional information
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overview tumor cells
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additional information
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the enzyme is produced by macrophages and exists in neutrophils and cancer cells
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additional information
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not detected in most of non-tumoral glandular epithelial cells
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additional information
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enzyme expression analysis in cancer patients, overview
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additional information
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enzyme expression analysis in cell and tissues, overview
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additional information
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the enzyme is upregulated in a wide variety of solid tumors including breast and colorectal cancers, association of the enzyme with tumor grade is evident in bladder, cervical, and renal cell cancer, but not in the other investigated cancers, in most cases, the enzyme appeared to be associated with poor prognosis, overview
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additional information
molecular weight and homodimer structure of human hepatic enzyme is similar to those of the enzymes from human amniochorion, blood platelet, placenta, psoriatic lesions, and the recombinant enzyme from a colorectal tumor. Detection by human placenta TP antisera binding to various preparations of hepatic TP
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additional information
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molecular weight and homodimer structure of human hepatic enzyme is similar to those of the enzymes from human amniochorion, blood platelet, placenta, psoriatic lesions, and the recombinant enzyme from a colorectal tumor. Detection by human placenta TP antisera binding to various preparations of hepatic TP
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additional information
thymidine phosphorylase (TP) expression is extremely low in healthy human tissues
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additional information
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overview tumor cells
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