2.4.2.4: thymidine phosphorylase
This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.
Word Map on EC 2.4.2.4
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2.4.2.4
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5-fluorouracil
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angiogenic
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colorectal
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thymidylate
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dihydropyrimidine
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capecitabine
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microvessels
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metastasis
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clinicopathological
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uridine
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mngie
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neurogastrointestinal
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tumour
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5'-deoxy-5-fluorouridine
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fluoropyrimidine
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thymine
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5\'-dfur
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resect
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encephalomyopathy
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prodrugs
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lymph
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intratumoral
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deoxyuridine
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uracil
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orotate
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phosphorolysis
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dysmotility
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tpi
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cachexia
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phosphorylases
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leukoencephalopathy
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ophthalmoplegia
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medicine
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5-fu-based
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ptosis
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taxanes
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pseudo-obstruction
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tegafur
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deoxyribose
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5-fluoro-2'-deoxyuridine
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viii-related
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hand-foot
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fdump
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ophthalmoparesis
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trifluorothymidine
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analysis
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5-fluorouridine
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anti-cd34
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5-fluorouracil-based
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tp-induced
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2'-deoxyuridine
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synthesis
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fluoropyrimidine-based
- 2.4.2.4
- 5-fluorouracil
-
angiogenic
- colorectal
- thymidylate
- dihydropyrimidine
- capecitabine
-
microvessels
- metastasis
-
clinicopathological
- uridine
-
mngie
-
neurogastrointestinal
- tumour
- 5'-deoxy-5-fluorouridine
-
fluoropyrimidine
- thymine
-
5\'-dfur
-
resect
-
encephalomyopathy
-
prodrugs
- lymph
-
intratumoral
- deoxyuridine
- uracil
- orotate
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phosphorolysis
-
dysmotility
- tpi
-
cachexia
- phosphorylases
- leukoencephalopathy
- ophthalmoplegia
- medicine
-
5-fu-based
-
ptosis
-
taxanes
- pseudo-obstruction
-
tegafur
- deoxyribose
- 5-fluoro-2'-deoxyuridine
-
viii-related
-
hand-foot
- fdump
- ophthalmoparesis
- trifluorothymidine
- analysis
- 5-fluorouridine
-
anti-cd34
-
5-fluorouracil-based
-
tp-induced
- 2'-deoxyuridine
- synthesis
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fluoropyrimidine-based
Reaction
Synonyms
angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP
ECTree
2.4.2.4 thymidine phosphorylaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.2.4 - thymidine phosphorylase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
5-fluoro-2'-deoxyuridine + phosphate
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the enzyme converts 5-fluorouracil to 5-fluoro-2'-deoxyuridine, activating the prodrug, overview. This action can only take place if there is enough co-substrate. 5-Fluorouracil prodrugs and metabolism, detailed overview
5-fluoro-2'-deoxyuridine is further converted by thymidine kinase to 5-fluoro-2'-deoxyuridine 5'-monophosphate
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?
uracil + 2-deoxy-alpha-D-ribose 1-phosphate
2'-deoxyuridine + phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization
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?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
-
r
thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
-
-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
intact platelets degrade thymidine but are not able to synthesize thymidine from thymine
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-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
-
the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors
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-
?
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
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the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly
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-
?
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
r
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
Escherichia coli B / ATCC 11303
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enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
-
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
degradation of uridine in tumor specimen
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
-
-
?
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
-
in Escherichia coli and Salmonella typhimurium thymidine phosphorylase plays an important role in metabolism of thymine auxotrophs and is necessary for the conversion of exogenous thymine to thymidine
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-
?
additional information
?
-
-
role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier
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-
?
additional information
?
-
-
formation of blood/brain barrier and repair following brain injury
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-
?
additional information
?
-
-
identical to platelet-derived endothelial cell growth factor
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-
?
additional information
?
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-
identical to platelet-derived endothelial cell growth factor
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-
?
additional information
?
-
-
mitogenic effect, promotes endothelial cell proliferation
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-
?
additional information
?
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expression of PD-ECGF/TP may play an important role in the progression of solid tumors
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-
?
additional information
?
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important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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-
?
additional information
?
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-
important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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-
?
additional information
?
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thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC
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-
?
additional information
?
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-
the enzyme stimulates formation of focal adhesions and the phosphorylation of Tyr397 of focal adhesion kinase, and it induces the expression and/or secretion of other angiogenic factors, overview. Thymidine phosphorylase promotes tumor growth and metastasis by preventing apoptosis and inducing angiogenesis, detailed overview. As gliostatin from fibroma cells, the enzyme inhibits the growth of both astrocytes and glial tumor cells
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-
?
additional information
?
-
-
thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium
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-
?
