2.4.2.4: thymidine phosphorylase

This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.4

2.4.2.4

5-fluorouracil

angiogenic

colorectal

thymidylate

dihydropyrimidine

capecitabine

microvessels

metastasis

clinicopathological

uridine

mngie

neurogastrointestinal

tumour

5'-deoxy-5-fluorouridine

fluoropyrimidine

thymine

5\'-dfur

resect

encephalomyopathy

prodrugs

lymph

intratumoral

deoxyuridine

uracil

orotate

phosphorolysis

dysmotility

tpi

cachexia

phosphorylases

leukoencephalopathy

ophthalmoplegia

medicine

5-fu-based

ptosis

taxanes

pseudo-obstruction

tegafur

deoxyribose

5-fluoro-2'-deoxyuridine

viii-related

hand-foot

fdump

ophthalmoparesis

trifluorothymidine

analysis

5-fluorouridine

anti-cd34

5-fluorouracil-based

tp-induced

2'-deoxyuridine

synthesis

fluoropyrimidine-based

Reaction

Synonyms

angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.4 thymidine phosphorylase

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Results	in table
31	Activating Compound
12092	AA Sequence
43	Application
1	CAS Registry Number
24	Cloned(Commentary)
14	Crystallization (Commentary)
6222	Disease/ Diagnostics
7	Expression
40	General Information
8	General Stability
366	IC50 Value
694	Inhibitors
3	kcat/KM [mM/s]
161	Ki Value [mM]
81	KM Value [mM]
17	Localization
34	Molecular Weight [Da]
82	Natural Substrates/ Products (Substrates)
366	Organism
6	Pathway
41	PDB ID
39	pH Optimum
4	pH Range
1	pH Stability
1	pI Value
2	Posttranslational Modification
27	Protein Variants
36	Purification (Commentary)
12	Reaction
2	Reaction Type
186	Reference
260	Source Tissue
40	Specific Activity [micromol/min/mg]
7	Storage Stability
289	Substrates and Products (Substrate)
30	Subunits
111	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
6	Temperature Stability [°C]
34	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 2.4.2.4 - thymidine phosphorylase

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Homo sapiens

assay at, pH 10 is used because 2-deoxy-D-ribose 1-phosphate is heat labile at pH 7.4

638459

5 - 8.5

Homo sapiens

P19971

thymidine phosphorolysis

5.3

5.5

thymine production, assay at

5.7

6.3

6.5

6.7

assay at

assay at

7.1

assay at

7.4

7.5

7.5 - 8

Salmonella enterica subsp. enterica serovar Typhimurium

rapid decrease of activity above and below this range

7.6

assay at

7.8

assay at

assay at

8.4

assay at