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2.4.2.4: thymidine phosphorylase

This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.4

Reaction

thymidine
+
phosphate
=
thymine
 +
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.4 thymidine phosphorylase

Specific Activity

Specific Activity on EC 2.4.2.4 - thymidine phosphorylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00002
-
wild-type mouse muscle
0.000205
-
wild-type mouse heart
0.000243
-
TP-/-UP-/- mouse liver
0.000285
-
wild-type mouse spleen
0.00067
-
wild-type mouse kidney
0.000862
-
wild-type mouse lung
0.00136
-
wild-type mouse brain
0.0014
-
wild-type mouse liver
0.00386
-
in normal uterine cervix tissue
0.00527
-
mean thymidine phosphorylase activity in population
0.00946
-
wild-type mouse small intestine
0.01
-
mitochondrial neurogastrointestinal encephalomyopathy syndrome patient, leukocytes
0.04176
-
in cancerous uterine cervix tissue
0.114
purified native enzyme, pH 8.0, 37°C, substrate uridine
0.2 - 0.32
-
leukocytes of heterozygous individuals in enzyme mutation and mitochondrial neurogastrointestinal encephalomyopathy syndrome
0.24
crude extract, at pH 7.5 at 37°C
0.36 - 0.8
-
wild-type activity in leukocytes
1.5
purified native enzyme, pH 8.0, 37°C, substrate 5-fluorouridine or 5'-deoxy-5-fluorouridine
18480
purified native enzyme, pH 8.0, 37°C
4.3
after 17.9fold purification, at pH 7.5 at 37°C
5.55
purified native enzyme, pH 8.0, 37°C, substrate thymidine
8.1
purified native enzyme, pH 8.0, 37°C, substrate 5-fluoro-2'-deoxyuridine
8.91
purified native enzyme, pH 8.0, 37°C, substrate 2'-deoxyuridine
additional information