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Literature summary for 2.4.2.4 extracted from
- Thymidine phosphorylase activity of platelet-derived endothelial cell growth factor is responsible for endothelial cell mitogenicity (1993), Eur. J. Biochem., 212, 201-210.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | - |
Escherichia coli | |
| additional information | iodination reduces activity, 63% inactivation after 5 min and complete inactivation after 20 min | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
thymidine | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | mitogenic effect, promotes endothelial cell proliferation | ? | - |
? | |
| thymine + 2-deoxy-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
? | |
| thymine + 2-deoxy-D-ribose 1-phosphate | Homo sapiens | - |
thymidine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
| 98% purity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | mitogenic effect, promotes endothelial cell proliferation | Homo sapiens | ? | - |
? | |
| thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
| thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
| thymine + 2-deoxy-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
? | |
| thymine + 2-deoxy-D-ribose 1-phosphate | - |
Homo sapiens | thymidine + phosphate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.157 | - |
thymidine | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.3 | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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