Application | Comment | Organism |
---|---|---|
medicine | thymidine phosphorylase activity might be useful in diagnostic characterization of ovarian cancer | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | Homo sapiens | the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | presurgery serum from 47 patients with ovarian cancer, and control serum from women with normal ovaries, treated surgically due to nononcological reasons. Significant higher enzyme activity in malignant serum specimen from ovarian cancer patients when compared to the control | Homo sapiens | - |
ovary | tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control | Homo sapiens | - |
ovary cancer cell | tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
thymidine + phosphate | the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly | Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |