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Literature summary for 2.4.2.4 extracted from

  • Miszczak-Zaborska, E.; Wojcik-Krowiranda, K.; Kubiak, R.; Bienkiewicz, A.; Bartkowiak, J.
    The activity of thymidine phosphorylase as a new ovarian tumor marker (2004), Gynecol. Oncol., 94, 86-92.
    View publication on PubMed

Application

Application Comment Organism
medicine thymidine phosphorylase activity might be useful in diagnostic characterization of ovarian cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymidine + phosphate Homo sapiens the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly thymine + 2-deoxy-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum presurgery serum from 47 patients with ovarian cancer, and control serum from women with normal ovaries, treated surgically due to nononcological reasons. Significant higher enzyme activity in malignant serum specimen from ovarian cancer patients when compared to the control Homo sapiens
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ovary tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control Homo sapiens
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ovary cancer cell tissue from 47 patiens with ovarian cancer after surgery. Significant higher enzyme activity in malignant tissue from ovarian cancer patients when compared to the control Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
?
thymidine + phosphate the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
?