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2.4.2.4: thymidine phosphorylase

This is an abbreviated version!
For detailed information about thymidine phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.4

Reaction

thymidine
+
phosphate
=
thymine
 +
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase, animal growth regulators, blood platelet-derived endothelial cell growth factors, blood platelet-derived endothelial cell growth factor, deoA, deoxythymidine phosphorylase, dthdpase, EC 2.4.2.23, gliostatin, gliostatins, GLS, HTP, More, PD-ECGF, PD-ECGF/TP, PD-ECGF/TP platelet-derived endothelial cell growth factor, PDECGF, phosphorylase, thymidine, platelet derived endothelial cell growth factor, platelet derived endothelial cell grwoth factor, platelet derived-endothelial cell growth factor, platelet-derived endothelial cell growth factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase, platelet-derived endotherial cell growth factor, ppnP, pynpase, pyrimidine deoxynucleoside phosphorylase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, TDRPASE, ThdPase, thymidine phosphorylase, thymidine Pi deoxyribosyltransferase, thymidine-orthophosphate deoxyribosyltransferase, thymidine:orthophosphate deoxy-D-ribosyltransferase, Tpase, TYMP

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.4 thymidine phosphorylase

IC50 Value

IC50 Value on EC 2.4.2.4 - thymidine phosphorylase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.085
(2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoic acid
Escherichia coli
-
pH 7.4, 25°C
0.044
(2R,3R,4S,5R)-9-(3,4-dihydroxy-5-trityloxymethyl-tetrahydrofuran-2-yl)-1,9-dihydropurin-6-one
Homo sapiens
pH and temperature not specified in the publication
0.264
(3-benzyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid
Homo sapiens
pH and temperature not specified in the publication
0.0537
(E)-1-((2-fluorophenyl)(hydroxyimino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0156
(E)-1-((4-chlorophenyl)(hydroxyimino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0107
(E)-1-((4-ethylphenyl)(hydroxyimino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0413
(E)-1-((4-fluorophenyl)(hydroxyimino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0334
(E)-1-((hydroxyimino)(3-methoxyphenyl)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0252
(E)-1-((hydroxyimino)(4-methoxyphenyl)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0225
(E)-1-((hydroxyimino)(p-tolyl)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0373
(E)-1-((hydroxyimino)(phenyl)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0032
(E)-2-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,4-diol
Escherichia coli
-
pH 7.4, 25°C
0.0376
(E)-2-(2-(2-chlorobenzylidene)hydrazinyl)quinoxaline
Escherichia coli
-
pH 7.4, 25°C
0.0336
(E)-2-(2-(2-fluorobenzylidene)hydrazinyl)quinoxaline
Escherichia coli
-
pH 7.4, 25°C
0.0734 - 0.0935
(E)-2-(2-(3-chlorobenzylidene)hydrazinyl)quinoxaline
0.0661
(E)-2-(2-(3-fluorobenzylidene)hydrazinyl)quinoxaline
Escherichia coli
-
pH 7.4, 25°C
0.0581
(E)-2-(2-(4-fluorobenzylidene)hydrazinyl)quinoxaline
Escherichia coli
-
pH 7.4, 25°C
0.0355
(E)-3-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,2-diol
Escherichia coli
-
pH 7.4, 25°C
0.0632
(E)-3-((2-(quinoxalin-2-yl)hydrazono)methyl)phenol
Escherichia coli
-
pH 7.4, 25°C
0.0091
(E)-4-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,2-diol
Escherichia coli
-
pH 7.4, 25°C
0.0086
(E)-4-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,3-diol
Escherichia coli
-
pH 7.4, 25°C
0.0334
(E)-4-((2-(quinoxalin-2-yl)hydrazono)methyl)phenol
Escherichia coli
-
pH 7.4, 25°C
0.0363
(E)-4-methoxy-2-((2-(quinoxalin-2-yl)hydrazono)methyl)phenol
Escherichia coli
-
pH 7.4, 25°C
0.0344
(E)-5-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-1,2,4-triol
Escherichia coli
-
pH 7.4, 25°C
0.0469
(E)-5-((2-(quinoxalin-2-yl)hydrazono)methyl)benzene-2,4,6-triol
Escherichia coli
-
pH 7.4, 25°C
0.0394
(E)-N'-(2,3-dimethoxybenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0086
(E)-N'-(2,4-dichlorobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0184
(E)-N'-(2-cyanobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0113
(E)-N'-(2-nitrobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0081
(E)-N'-(3,5-dichloro-2-hydroxybenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0361
(E)-N'-(3-cyanobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0161
(E)-N'-(3-hydroxy-5-methoxybenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0184
(E)-N'-(4-chlorobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0222
(E)-N'-(4-cyanobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0214
(E)-N'-(4-nitrobenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0447
(E)-N'-(5-bromo-2-methoxybenzlidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0693
(E)-N'-(anthracen-9-ylmethylen)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0493
(Z)-1-((2-fluorophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.00012
(Z)-1-((3,4-dichlorophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0412
(Z)-1-((3-fluorophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0027
(Z)-1-((4-bromophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0014
(Z)-1-((4-chlorophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0034
(Z)-1-((4-ethylphenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0441
(Z)-1-((4-fluorophenyl)(hydroxyimino)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0251
(Z)-1-((hydroxyimino)(3-methoxyphenyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0165
(Z)-1-((hydroxyimino)(4-methoxyphenyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0159
(Z)-1-((hydroxyimino)(m-tolyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0072
(Z)-1-((hydroxyimino)(p-tolyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0214
(Z)-1-((hydroxyimino)(phenyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0399
(Z)-1-((hydroxyimino)(thiophen-2-yl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.0276
(Z)-N'-(1-(4-nitrophenyl)ethylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0081
(Z)-N'-(3-chloro-4-hydroxybenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0044
(Z)-N'-(4-hydroxy-3,5-dimethoxybenzylidene)isoquinoline-3-carbohydrazide
Escherichia coli
pH 7.4, 25°C
0.0856
1-((methoxyimino)(phenyl)methyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.103
1-(2-phenylethyl)imidazolidine-2,4,5-trione
Homo sapiens
pH and temperature not specified in the publication
0.0924
1-benzoyl-6-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH 8.4, 30°C
0.115
1-benzyl-imidazolidine-2,4,5-trione
Escherichia coli
-
pH 7.4, 25°C
0.115
1-benzylimidazolidine-2,4,5-trione
Homo sapiens
pH and temperature not specified in the publication
0.128
1-[(2-methylphenyl)methyl]imidazolidine-2,4,5-trione
Homo sapiens
pH and temperature not specified in the publication
0.04
1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.1
2,7-bis(methylsulfanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5(4H)-one
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.0595
2-(2',5'-dihydroxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.0011
2-(2-methyl-1H-indol-3-yl)-N'-(2,4,6-trihydroxybenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0222
2-(2-methyl-1H-indol-3-yl)-N'-(2-methylbenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0158
2-(2-methyl-1H-indol-3-yl)-N'-(2-nitrobenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0411
2-(2-methyl-1H-indol-3-yl)-N'-(3-methylbenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0222
2-(2-methyl-1H-indol-3-yl)-N'-(3-nitrobenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0381
2-(2-methyl-1H-indol-3-yl)-N'-(4-methylbenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0132
2-(2-methyl-1H-indol-3-yl)-N'-(4-nitrobenzylidene)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0429
2-(3',4'-dihydroxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.256
2-(3'-ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.1688
2-(3'-hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.295
2-(3'-hydroxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.01084
2-(3,4-dichlorophenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0429
2-(3,4-dihydroxyphenyl)quinazolin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.03178
2-(3-bromophenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.03442
2-(3-methylphenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.234
2-(4'-hydroxyphenyl)quinazolin-4(3H)-one
Escherichia coli
-
at pH 7.0 and 30°C
0.01309
2-(4-bromo-3-methylphenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.02206
2-(4-bromophenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.03158
2-(4-methylphenyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.05538
2-(benzylsulfanyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.03637
2-(diphenylmethyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
pH and temperature not specified in the publication
0.03154
2-(furan-2-yl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.05167
2-(methylsulfanyl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.1
2-(methylsulfanyl)-7-sulfanylidene-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5(4H)-one
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.1
2-(methylsulfanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7(4H,6H)-dione
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.02453
2-(pyridin-2-yl)-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.013 - 0.04332
2-benzyl-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
0.03956
2-phenyl-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
0.1
2-phenyl-7-sulfanylidene-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5(4H)-one
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.0462
2-phenylquinazolin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.1
2-phenyl[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7(4H,6H)-dione
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.05988
2-[(2-phenylethyl)sulfanyl]-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.013
2-[(3,4-dichlorophenyl)methyl]-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
pH and temperature not specified in the publication
0.05925
2-[(3-phenylpropyl)sulfanyl]-5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.1634
2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid
Escherichia coli
pH 7.4, 25°C
0.0946
2-[(5-(3-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid
Escherichia coli
pH 7.4, 25°C
0.0439
2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid
Escherichia coli
pH 7.4, 25°C
0.2206
2-[(5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl)thio]propanoic acid
Escherichia coli
pH 7.4, 25°C
0.1438
2-[(5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid
Escherichia coli
pH 7.4, 25°C
0.0645
2-[(5-(4-nitrophenyl)-4H-1,2,4-triazol-3-yl)thio]acetic acid
Escherichia coli
pH 7.4, 25°C
0.013
2-[[(5-chloro-2-methylidene-6-oxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]sulfanyl]-7-phenyl-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.037
3,3'-(1,3,4-oxadiazole-2,5-diyl)dipyridine
Homo sapiens
pH and temperature not specified in the publication
0.0446
3-(((4-chlorophenyl)amino)methyl)-5-(2-iodophenyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.1833
3-((4-benzylpiperazin-1-yl)methyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0547
3-((5-(4-chlorophenyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)methyl)thiazolidine-2,4-dione
Homo sapiens
pH 7.4, 25°C
0.0303
3-((benzylamino)methyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.04
3-(2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)-propionamide
Escherichia coli
-
pH 7.4, 25°C
0.106
3-(3-benzyl-2,4,5-trioxoimidazolidin-1-yl)propanamide
Homo sapiens
pH and temperature not specified in the publication
0.1041
3-(anilinomethyl)-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.473
3-([(1-benzyl-2-hydroxyethyl)imino]methyl)-4Hchromen-4-one
Escherichia coli
-
pH 7.6
0.04
3-([(2, 4-dichlorophenyl)imino]methyl)-4H-chromen-4-one
Escherichia coli
-
pH 7.6
0.15
3-([(2-([-(4-oxo-4H-chromen-3-yl)methylidene]amino)ethyl)imino] methyl)-4H-chromen-4-one
Escherichia coli
-
pH 7.6
0.076
3-([(2-benzoyl-4-chlorophenyl)imino]methyl)-4Hchromen-4-one
Escherichia coli
-
pH 7.6
0.48
3-([(2-methyl-6-nitrophenyl)imino]methyl)-4Hchromen-4-one
Escherichia coli
-
pH 7.6
0.34
3-([(3-hydroxy-2-pyridinyl)imino]methyl)-4H-chromen-4-one
Escherichia coli
-
pH 7.6
0.02
3-([(3-methoxy-4-methylphenyl)imino]methyl)-4Hchromen-4-one
Escherichia coli
-
pH 7.6
0.067
3-([(3-methylphenyl)imino]methyl)-4H-chromen-4-one
Escherichia coli
-
pH 7.6
0.0237
3-[(2,3-dimethylanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.1305
3-[(2-chloroanilino)methyl]-5-(2-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.04638
3-[(2-chloroanilino)methyl]-5-(4-chlorophenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.1177
3-[(2-chloroanilino)methyl]-5-phenyl-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.0144
3-[(2-methoxy-6-nitroanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH and temperature not specified in the publication
0.08724
3-[(2-methoxyanilino)methyl]-5-phenyl-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.1172
3-[(2-methylanilino)methyl]-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.061
3-[(2-methylphenyl)methyl]-1H-2-benzopyran-1-one
Homo sapiens
pH and temperature not specified in the publication
0.1338
3-[(3,4-dichloroanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.08319
3-[(3,4-dimethylanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.04061
3-[(3,4-dimethylanilino)methyl]-5-phenyl-1,3,4-oxadiazole-2(3H)-thione
0.0844
3-[(3-methoxyanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.04064
3-[(3-methoxyanilino)methyl]-5-phenyl-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.02633
3-[(4-bromoanilino)methyl]-5-(2-bromophenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.1732
3-[(4-bromoanilino)methyl]-5-(4-chlorophenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.05472
3-[(4-methylanilino)methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.04029
3-[(E)-[(2,4-dichlorophenyl)imino]methyl]-4H-1-benzopyran-4-one
Homo sapiens
pH and temperature not specified in the publication
0.01977
3-[(E)-[(3-methoxy-4-methylphenyl)imino]methyl]-4H-1-benzopyran-4-one
Homo sapiens
pH and temperature not specified in the publication
0.04
3-[2,4,5-trioxo-3-(2-phenylethyl)imidazolidin-1-yl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.066
3-[3-(3-chlorobenzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionamide
Escherichia coli
-
pH 7.4, 25°C
0.088
3-[3-[(2-methylphenyl)methyl]-2,4,5-trioxoimidazolidin-1-yl]propanamide
Homo sapiens
pH and temperature not specified in the publication
0.06932
3-[[(2-phenylethyl)amino]methyl]-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.0144
3-[[(4-methoxy-3'-nitro[1,1'-biphenyl]-3-yl)amino]methyl]-5-(4-methylphenyl)-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.2734
4,5-diphenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
Escherichia coli
pH 7.4, 25°C
0.003
4-(2,5-difluorobenzyl)-N-(2-fluorophenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0025
4-(2,5-difluorobenzyl)-N-(2-methoxyphenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0012
4-(2,5-difluorobenzyl)-N-(3-fluorophenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0122
4-(2,5-difluorobenzyl)-N-(3-methoxyphenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0323
4-(2,5-difluorobenzyl)-N-(3-nitrophenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.002
4-(2,5-difluorobenzyl)-N-(4-(trifluoromethyl)phenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.6
4-(2,5-difluorobenzyl)-N-(4-fluorophenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0116
4-(2,5-difluorobenzyl)-N-(4-methoxyphenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0081
4-(2,5-difluorobenzyl)-N-(4-nitrophenyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0223
4-(2,5-difluorobenzyl)-N-(m-tolyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0143
4-(2,5-difluorobenzyl)-N-(o-tolyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0173
4-(2,5-difluorobenzyl)-N-(p-tolyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0146
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(1-(4-nitrophenyl)ethylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0011
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(2,3,4-trihydroxybenzylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0546
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(2,3,4-trimethoxybenzylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0063
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(2-nitrobenzylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0473
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(3,4,5-trimethoxybenzylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0283
4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)-N'-(4-(phenoxymethyl)benzylidene)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.022
4-[(Z)-[(3-hydroxynaphthalen-2-yl)methylidene]amino]-1,5-dimethyl-2-phenylpyrazolidin-3-one
Homo sapiens
pH and temperature not specified in the publication
0.146
5'-O-(2'',4''-dichlorobenzoyl)-thymidine-3'-O-2'',4''-dichlorobenzoate
Escherichia coli
pH not specified in the publication, 30°C
0.09
5'-O-(2''-methoxybenzoyl)-thymidine
Escherichia coli
pH not specified in the publication, 30°C
0.0333
5'-O-(3''-bromobenzoyl)-thymidine
Escherichia coli
pH not specified in the publication, 30°C
0.0075
5'-O-(4''-bromobenzoyl)-thymidine-3'-O-4''-bromobenzoate
Escherichia coli
pH not specified in the publication, 30°C
0.0188
5'-O-(4''-methoxybenzoyl)-thymidine
Escherichia coli
pH not specified in the publication, 30°C
0.0185
5'-O-(4''-methylbenzoyl)-thymidine
Escherichia coli
pH not specified in the publication, 30°C
0.044 - 0.067
5'-O-trityl-inosine
0.02183
5-(2-bromophenyl)-3-[(2-chloroanilino)methyl]-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.0176
5-(2-bromophenyl)-3-[(2-methoxyanilino)methyl]-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.0872
5-(2-chlorophenyl)-3-(((4-chlorophenyl)amino)(phenyl)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0464
5-(2-chlorophenyl)-3-((thiazol-2-ylamino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.062
5-(3-chlorophenyl)-4H-1,2,4-triazole-3-thiol
Escherichia coli
pH 7.4, 25°C
0.1123
5-(3-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
Escherichia coli
pH 7.4, 25°C
0.0384
5-(4-chlorophenyl)-3-(((2-nitrophenyl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0693
5-(4-chlorophenyl)-3-(((3,3-diphenylpropyl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0237
5-(4-chlorophenyl)-3-(((4-hydroxyphenyl)amino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0297
5-(4-chlorophenyl)-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0582
5-(4-chlorophenyl)-3-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0832
5-(4-chlorophenyl)-3-((4-cyclohexylpiperazin-1-yl)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0506
5-(4-chlorophenyl)-3-((cyclohexylamino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.0228
5-(4-chlorophenyl)-3-((dicyclohexylamino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.1171
5-(4-chlorophenyl)-3-((naphthalen-1-ylamino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.1505
5-(4-chlorophenyl)-3-((thiazol-2-ylamino)methyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH 7.4, 25°C
0.08873
5-(4-chlorophenyl)-3-[(2-methoxyanilino)methyl]-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.05821
5-(4-chlorophenyl)-3-[(2-methylanilino)methyl]-1,3,4-oxadiazole-2(3H)-thione
Escherichia coli
-
at pH 7.4 and 25°C
0.1876
5-(4-chlorophenyl)-4H-1,2,4-triazole-3-thiol
Escherichia coli
pH 7.4, 25°C
0.03824
5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH and temperature not specified in the publication
0.0823
5-(4-pyridyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
Escherichia coli
pH 7.4, 25°C
0.1112
5-(benzylsulfanyl)-2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
pH and temperature not specified in the publication
0.09505
5-(methylsulfanyl)-2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
pH and temperature not specified in the publication
0.038
5-bromo-6-(3'-methylimidazol-1-yl)uracil
Homo sapiens
IC50: 0.038 mM
0.0244 - 0.16
5-bromo-6-[(2'-nitroimidazol-1'-yl)methyl]uracil
0.017
5-bromo-6-[(3-methylimidazol-1-yl)methyl]uracil
Homo sapiens
IC50: 0.017 mM
0.0066 - 0.181
5-bromo-6-[(4'-nitroimidazol-1'-yl)methyl]uracil
0.0056
5-bromo-6-[[(1,3-dihydroxypropan-2-yl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.04 - 0.1
5-bromo-6-[[(2,3-dihydroxypropyl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
0.024
5-bromo-6-[[(2-hydroxyethyl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.035
5-chloro-6-(3'-methylimidazol-1-yl)uracil
Homo sapiens
IC50: 0.035 mM
0.0217 - 0.115
5-chloro-6-[(2'-nitroimidazol-1'-yl)methyl]uracil
0.018
5-chloro-6-[(3-methylimidazol-1-yl)methyl]uracil
Homo sapiens
IC50: 0.018 mM
0.007 - 0.2
5-chloro-6-[(4'-nitroimidazol-1'-yl)methyl]uracil
0.00036
5-chloro-6-[([4-oxo-8-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazin-2-yl]sulfanyl)methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.000035
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride
Homo sapiens
pH and temperature not specified in the publication
0.000035
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracil
Homo sapiens
-
-
0.00002 - 0.000023
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracilhydrochloride
0.001
5-chloro-6-[[(1,3-dihydroxypropan-2-yl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.039
5-chloro-6-[[(2-hydroxyethyl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.034
5-iodo-6-[[(piperidin-1-yl)amino]methyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.05
5-phenyl-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
pH and temperature not specified in the publication
0.03095
5-sulfanylidene-2-(thiophen-2-yl)-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.05813
5-sulfanylidene-5,6-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(4H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0032
5-[(E)-[2-(quinoxalin-2-yl)hydrazinylidene]methyl]benzene-1,2,4-triol
Homo sapiens
pH and temperature not specified in the publication
0.00012
6-(((1,3-dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.11
6-(3-methylimidazol-1-yl)uracil
Homo sapiens
IC50: 0.110 mM
0.017
6-amino-5-bromopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.0016 - 0.017
6-amino-5-bromouracil
0.07
6-aminothymine
Homo sapiens
pH and temperature not specified in the publication
0.0000187 - 0.000019
6-[(2'-aminoimidazol-1'-yl)methyl]-5-bromouracil
0.0000206 - 0.000049
6-[(2'-aminoimidazol-1'-yl)methyl]-5-chlorouracil
0.0001 - 0.00056
6-[(2'-aminoimidazol-1'-yl)methyl]uracil
0.0024 - 0.2577
6-[(2'-nitroimidazol-1'-yl)methyl]uracil
0.06
6-[(3-methylimidazol-1-yl)methyl]thymine
Homo sapiens
IC50: 0.06 mM
0.042
6-[(3-methylimidazol-1-yl)methyl]uracil
Homo sapiens
IC50: 0.042 mM
0.00065 - 0.041
6-[(4'-aminoimidazol-1'-yl)methyl]-5-bromouracil
0.00073 - 0.026
6-[(4'-aminoimidazol-1'-yl)methyl]-5-chlorouracil
0.1014 - 0.143
6-[(4'-aminoimidazol-1'-yl)methyl]uracil
0.0138 - 0.5
6-[(4'-nitroimidazol-1'-yl)methyl]uracil
0.0084
6-[(dimethylamino)methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.028
6-[(dipentylamino)methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.1
6-[(dipropylamino)methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
above, pH and temperature not specified in the publication
0.036
6-[[(2,3-dihydroxypropyl)(methyl)amino]methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.012
6-[[(2-hydroxyethyl)amino]methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.087
6-[[bis(2-ethoxyethyl)amino]methyl]-5-iodopyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH and temperature not specified in the publication
0.0066
7-(4-tert-butylphenyl)-2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0015 - 0.0097
7-(4-tert-butylphenyl)-2-[[(5-chloro-2-methylidene-6-oxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]sulfanyl]-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
0.1
7-(methylsulfanyl)-2-phenyl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5(4H)-one
Homo sapiens
-
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.0065 - 0.045
7-deazaxanthine
0.0462
7-phenyl-2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0263
8-phenyl-2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00004
8-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0002
cycloheximide
Escherichia coli
-
at pH 7.0 and 30°C
0.342
ethyl (3-benzyl-2,4,5-trioxoimidazolidin-1-yl)acetate
Homo sapiens
pH and temperature not specified in the publication
0.02564
ethyl 4-(4-chlorophenyl)-2-oxo-6-([(pyridin-4-yl)formohydrazido]methyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.00914
ethyl 4-(4-chlorophenyl)-2-oxo-6-([[(5-phenyl-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl)methyl]amino]methyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.03226
ethyl 4-(4-chlorophenyl)-2-oxo-6-[[(E)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]methyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.05334
ethyl 4-(4-chlorophenyl)-6-((3-methyl-5-oxo-2H-pyrazol-1(5H)-yl)methyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.08735
ethyl 4-(4-chlorophenyl)-6-([(E)-[(4-chlorophenyl)methylidene]amino]methyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.118
ethyl 4-(4-chlorophenyl)-6-([(E)-[(4-methoxyphenyl)methylidene]amino]methyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.1505
ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.00657
ethyl 4-(4-chlorophenyl)-6-[([[5-(4-chlorophenyl)-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl]methyl]amino)methyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.0118
ethyl 4-(4-chlorophenyl)-6-[([[5-(4-methoxyphenyl)-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl]methyl]amino)methyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.00109
ethyl 4-(4-chlorophenyl)-6-[([[5-(4-methylphenyl)-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl]methyl]amino)methyl]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.1291
ethyl 6-((1H-imidazol-1-yl)methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.04065
ethyl 6-((2-aminobenzoyloxy)methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetra-hydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.0385 - 0.1236
ethyl 6-((benzylamino)methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate
0.09525
ethyl 6-(benzoyloxymethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.06464
ethyl 6-([(E)-[(4-bromophenyl)methylidene]amino]methyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.279
ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.0145
ethyl 6-[([[5-(4-bromophenyl)-2-sulfanylidene-1,3,4-oxadiazol-3(2H)-yl]methyl]amino)methyl]-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Escherichia coli
pH 7.0, 30°C
0.357
ethyl [2,4,5-trioxo-3-(2-phenylethyl)imidazolidin-1-yl]acetate
Homo sapiens
pH and temperature not specified in the publication
0.303
ethyl [3-[(2-methylphenyl)methyl]-2,4,5-trioxoimidazolidin-1-yl]acetate
Homo sapiens
pH and temperature not specified in the publication
0.232 - 0.351
KIN56
0.0116
methyl-4-((2-(2-(2-methyl-1H-indol-3-yl)acetyl)hydrazono)methyl)benzoate
Escherichia coli
pH 7.4, 25°C
0.0012
N'-(2,3-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0033
N'-(2,4-dichlorobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0056
N'-(2,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0092
N'-(2,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0185
N'-(2-cyanobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0073
N'-(2-hydroxy-3-methoxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0066
N'-(2-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0361
N'-(2-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0014
N'-(3,4-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0024
N'-(3,5-dichloro-2-hydroxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0039
N'-(3,5-dihydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0011
N'-(3-aminobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0184
N'-(3-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0274
N'-(3-cyanobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0048
N'-(3-hydroxy-4-methoxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0046
N'-(3-hydroxy-4-methoxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0185
N'-(3-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0311
N'-(4-(dimethylamino)benzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0188
N'-(4-(dimethylamino)benzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0199
N'-(4-chlorobenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0164
N'-(4-chlorobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0221
N'-(4-cyanobenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0053
N'-(4-hydroxy-3,5-dimethoxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.006
N'-(4-hydroxy-3-methoxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0082
N'-(4-hydroxybenzylidene)-2-(2-methyl-1H-indol-3-yl)acetohydrazide
Escherichia coli
pH 7.4, 25°C
0.0367
N'-(5-bromo-2-methoxybenzylidene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.0394
N'-(anthracen-9-ylmethylene)-4-(5-(isoquinolin-3-yl)-1,3,4-oxadiazol-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 25°C
0.146
N'-[-(4-oxo-4H-chromen-3-yl)methylidene]propanohydrazide
Escherichia coli
-
pH 7.6
0.0256
N-((5-(4-chlorophenyl)-2-thioxo-1,3,4-oxadiazole-3(2H)-yl)methyl)3(trifluoromethyl) benzamide
Homo sapiens
pH 7.4, 25°C
0.0191
N-(2-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0011
N-(2-chlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0016
N-(3,4-dichlorophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0146
N-(3-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.0246
N-(4-bromophenyl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.00382
N-(4-oxo-2-sulfanylidene-8-[[4-(trifluoromethyl)phenyl]methyl]-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazin-7-yl)thiourea
Homo sapiens
pH and temperature not specified in the publication
0.02992
N-(8-benzyl-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrazolo[1,5-a][1,3,5]triazin-7-yl)thiourea
Homo sapiens
pH and temperature not specified in the publication
0.0422
N-(adamantan-1-yl)-4-(2,5-difluorobenzyl)piperazine-1-carbothioamide
Escherichia coli
pH 7.4, 25°C
0.077
NSC 65043
Homo sapiens
-
IC50: 0.077 mM
0.06545
symplocomoside
Homo sapiens
pH and temperature not specified in the publication
0.22567
symponoside
Homo sapiens
pH and temperature not specified in the publication
0.00003 - 0.035
TPI
0.085
[2,4,5-trioxo-3-(2-phenylethyl)imidazolidin-1-yl]acetic acid
Homo sapiens
pH and temperature not specified in the publication
0.236
[3-[(2-methylphenyl)methyl]-2,4,5-trioxoimidazolidin-1-yl]acetic acid
Homo sapiens
pH and temperature not specified in the publication
0.0017 - 0.027
[8-(2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-1-yl)octyl]phosphonic acid
0.0073 - 0.0151
[8-(2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-1-yl)octyl]phosphonic acid
0.000045
[[(2R,4S)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.00025
[[(2R,4S)-2-(hydroxymethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]methyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.000015
[[(2S,4S)-2-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonothioyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.000011
[[(2S,4S)-2-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.00022
[[(3R,4R)-3-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.000045
[[(3R,4R)-3-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]methyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.00019
[[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonothioyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.00035
[[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)pyrrolidin-1-yl]carbonyl]phosphonic acid
Rattus norvegicus
-
pH 6.7
0.0003
[[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1-(prop-2-en-1-yloxy)ethoxy]methyl]phosphonic acid
Rattus norvegicus
-
about, pH 6.7
0.00075
[[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1-phenoxyethoxy]methyl]phosphonic acid
Rattus norvegicus
-
pH 6.7