Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.4 extracted from

  • Temmink, O.H.; de Bruin, M.; Turksma, A.W.; Cricca, S.; Laan, A.C.; Peters, G.J.
    Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines (2007), Int. J. Biochem. Cell Biol., 39, 565-575.
    View publication on PubMed
Search for more literature for 2.4.2.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Colo-320TP1 and C26A cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Colo-320 cell
-
 Homo sapiens
-
colonic cancer cell
-
 Homo sapiens
-
HaCaT cell
-
 Homo sapiens
-
SW-1398 cell
-
 Homo sapiens
-
SW-948 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxy-D-ribose 1-phosphate
-
 ?
5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + D-ribose 1-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.017
-
 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride in 50 mM Tris, 1 mM EDTA, pH 7.4, at 37°C Homo sapiens