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Literature summary for 2.4.2.4 extracted from
- The cytosol activity of thymidine phosphorylase in endometrial cancer (2008), J. Exp. Clin. Cancer Res., 27, 64.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium | ? | - |
? |  |
| thymidine + phosphate | Homo sapiens | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
| endometrial carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium | Homo sapiens | ? | - |
? | |
| thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PD-ECGF | - |
Homo sapiens |
| PD-ECGF/TP | - |
Homo sapiens |
| platelet-derived endothelial cell growth factor | - |
Homo sapiens |
| platelet-derived endothelial cell growth factor/thymidine phosphorylase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | thymidine phosphorylase promotes angiogenesis. The mechanism of endometrial angiogenesis involves the enzyme and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium | Homo sapiens |
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Release 2023.1 (January 2023)
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