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Information on EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing)

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IUBMB Comments
Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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Synonyms
glutamine amidotransferase, gmp synthetase, gatase, guanosine monophosphate synthetase, xmp aminase, guanosine 5'-monophosphate synthetase, guanine monophosphate synthetase, pd0279, guanylate synthetase, di-gmp synthase a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
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ATP + XMP + NH3 = AMP + diphosphate + GMP
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(1b)
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L-glutamine + H2O = L-glutamate + NH3
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(1a)
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