Reference on EC 6.3.5.2 - GMP synthase (glutamine-hydrolysing)
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hirai, K.; Matsuda, Y.; Nakagawa, H.
Purification and characterization of GMP synthetase from Yoshida sarcoma ascites cells
J. Biochem.
102
893-902
1987
Rattus norvegicus
Maruyama, A.; Nishi, T.; Ozaki, A.; Ito, S.; Fujio, T.
Construction of a plasmid for high level expression of XMP aminase in Escherichia coli
Agric. Biol. Chem.
50
1879-1884
1986
Escherichia coli
-
Fujio, T.; Nishi, T.; Ito, S.; Maruyama, A.
High level expression of XMP aminase in Escherichia coli and its application for the industrial production of 5-guanylic acid
Biosci. Biotechnol. Biochem.
61
840-845
1997
Escherichia coli
Zalkin, H.
GMP synthetase
Methods Enzymol.
113
273-278
1985
Escherichia coli, Escherichia coli B96
Tiedeman, A.A.; Smith, J.M.; Zalkin, H.
Nucleotide sequence of the guaA gene encoding GMP synthetase of Escherichia coli K12
J. Biol. Chem.
260
8676-8679
1985
Escherichia coli
Spector, T.
GMP synthetase from Ehrlich ascites cells
Methods Enzymol.
51
219-224
1978
Mus musculus
Sakamoto, N.
GMP synthetase (Escherichia coli)
Methods Enzymol.
51
213-218
1978
Escherichia coli, Escherichia coli B96
Spector, T.; Jones, T.E.; Krenitsky, T.A.; Harvey, R.J.
Guanosine monophosphate synthetase from Ehrlich ascites cells. Multiple inhibition by pyrophosphate and nucleosides
Biochim. Biophys. Acta
452
597-607
1976
Mus musculus
Spector, T.; Beacham III, L.M.
Guanosine monophosphate synthetase from Escherichia coli B-96. Inhibition by nucleosides
J. Biol. Chem.
250
3101-3107
1975
Escherichia coli, Escherichia coli B96
Spector, T.
Studies with GMP synthetase from Ehrlich ascites cells. Purification, properties, and interactions with nucleotide analogs
J. Biol. Chem.
250
7372-7376
1975
Mus musculus
Spector, T.; Miller, R.L.; Fyfe, J.A.; Krenitsky, T.A.
GMP synthetase from Escherichia coli B-96. Interactions with substrate analogs
Biochim. Biophys. Acta
370
585-591
1974
Escherichia coli, Escherichia coli B96
Lee, B.H.; Hartman, S.C.
Preferential utilization of glutamine for amination of xanthosine 5'-phosphate to guanosine 5'-phosphate by purified enzymes from Escherichia coli
Biochem. Biophys. Res. Commun.
60
918-925
1974
Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia coli B96
Sakamoto, N.; Hatfield, G.W.; Moyed, H.S.
Denaturation and renaturation of xanthosine 5¦-phosphate aminase
J. Biol. Chem.
247
5888-5891
1972
Escherichia coli, Escherichia coli B96
Sakamoto, N.; Hatfield, G.W.; Moyed, H.S.
Physical properties and subunit structure of xanthosine 5'-phosphate aminase
J. Biol. Chem.
247
5880-5887
1972
Escherichia coli, Escherichia coli B96
Greer, W.L.; Wellman, A.M.
Isolation and characterization of guanine auxotrophs in Neurospora crassa
Can. J. Microbiol.
26
1412-1415
1980
Neurospora crassa
Matsui, H.; Sato, K.; Enei, H.; Hirose, Y.
Guanosine production and purine nucleotide biosynthetic enzymes in guanosine mutants of Bacillus subtilis
Agric. Biol. Chem.
43
1317-1323
1979
Bacillus subtilis
-
Gardner, W.J.E.; Woods, R.A.
Isolation and characterisation of guanine auxotrophs in Saccharomaces cerevisiae
Can. J. Microbiol.
25
380-389
1979
Saccharomyces cerevisiae
Hirst, M.; Haliday, E.; Nakamura, J.; Lou, L.
Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
J. Biol. Chem.
269
23830-23837
1994
Homo sapiens
Nakamura, J.; Lou, L.
Biochemical characterization of human GMP synthetase
J. Biol. Chem.
270
7347-7353
1995
Homo sapiens
Nakamura, J.; Straub, K.; Wu, J.; Lou, L.
The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine
J. Biol. Chem.
270
23450-23455
1995
Homo sapiens
Lou, L.; Nakamura, J.; Tsing, S.; Nguyen, B.; Chow, J.; Straub, K.; Chan, H.; Barnett, J.
High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase
Protein Expr. Purif.
6
487-495
1995
Homo sapiens
Tesmer, J.J.G.; Stemmler, T.L.; Penner-Hahn, J.E.; Davisson, V.J.; Smith, J.L.
Preliminary X-ray analysis of Escherichia coli GMP synthetase: determination of anomalous scattering factors for a cysteinyl mercury derivative
Proteins Struct. Funct. Genet.
18
394-403
1994
Escherichia coli
Tesmer, J.J.G.; Klem, T.J.; Deras, M.L.; Davisson, V.J.; Smith, J.L.
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families
Nat. Struct. Biol.
1
74-86
1996
Escherichia coli
-
Kameyama, T.; Takahashi, A.; Matsumoto, H.; Kurasawa, S.; Hamada, M.; Okami, Y.; Ishizuka, M.; Takeuchi, T.
Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties
J. Antibiot.
41
1561-1567
1988
Mus musculus
Worrell, V.E.; Nagle, D.P.
Genetic and physiological characterization of the purine salvage pathway in the archaebacterium Methanobacterium thermoautotrophicum Marburg
J. Bacteriol.
172
3328-3334
1990
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
Matsui, H.; Sato, K.; Enei, H.; Hirose, Y.
Production of guanosine by psicofuranine and decoyinine resistant mutants of Bacillus subtilis
Agric. Biol. Chem.
43
1739-1744
1979
Bacillus subtilis
-
Patel, N.; Moyed, H.S.; Kane, J.F.
Properties of xanthosine 5'-monophosphate-amidotransferase from Escherichia coli
Arch. Biochem. Biophys.
178
652-661
1977
Escherichia coli, Escherichia coli B96
Zalkin, H.; Truitt, C.D.
Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase
J. Biol. Chem.
252
5431-5436
1977
Escherichia coli
Patel, N.; Moyed, H.S.; Kane, J.F.
Xanthosine-5'-phosphate amidotransferase from Escherichia coli
J. Biol. Chem.
250
2609-2613
1975
Escherichia coli, Escherichia coli B96
Lagerkvist, U.
Biosynthesis of guanosine 5'-phosphate. II. Amination of xanthosine 5'-phosphate by purified enzyme from pigeon liver
J. Biol. Chem.
233
143-149
1958
Pigeon
Boritzki, T.J.; Jackson, R.C.; Morris, H.P.; Weber, G.
Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors
Biochim. Biophys. Acta
658
102-110
1981
Rattus norvegicus
Dujardin, G.; Kermorgant, M.; Slonimski, P.P.; Boucherie, H.
Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae
Gene
139
127-132
1994
Saccharomyces cerevisiae
Van Lookeren Campagne, M.M.; Franke, J.; Kessin, R.H.
Functional cloning of a Dictyostelium discoideum cDNA encoding GMP synthetase
J. Biol. Chem.
266
16448-16452
1991
Dictyostelium discoideum
Kusumi, T.; Tsuda, M.; Katsunuma, T.; Yamamura, M.
Dual inhibitory effect of bredinin
Cell Biochem. Funct.
7
201-204
1989
Mus musculus
Deras, M.L.; Chittur, S.V.; Davisson, V.J.
N2-hydroxyguanosine 5'-monophosphate is a time-dependent inhibitor of Escherichia coli guanosine monophosphate synthetase
Biochemistry
38
303-310
1999
Escherichia coli
Chittur, S.V.; Klem, T.J.; Shafer, C.M.; Davisson, V.J.
Mechanism for acivicin inactivation of triad glutamine amidotransferases
Biochemistry
40
876-887
2001
Escherichia coli (P04079), Escherichia coli
Pegram, L.D.; Megonigal, M.D.; Lange, B.J.; Nowell, P.C.; Rowley, J.D.; Rappaport, E.F.; Felix, C.A.
t(1;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5' monophosphate synthetase) gene
Blood
96
4360-4362
2000
Homo sapiens
Grimaldi, C.; Dutertre, M.; Simonet, J.M.
Genetic organization and polymorphism of the guaA gene encoding the GMP synthetase in Lactobacillus rhamnosus
Curr. Microbiol.
40
245-249
2000
Lacticaseibacillus rhamnosus (O85192), Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus X202 (O85192)
McConkey, G.A.
Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase
Exp. Parasitol.
94
23-32
2000
Plasmodium falciparum (Q9U775), Plasmodium falciparum
Munagala, N.R.; Wang, C.C.
Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis
Mol. Biochem. Parasitol.
127
143-149
2003
Trichomonas vaginalis
van der Knaap, J.A.; Kumar, B.R.; Moshkin, Y.M.; Langenberg, K.; Krijgsveld, J.; Heck, A.J.; Karch, F.; Verrijzer, C.P.
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Mol. Cell
17
695-707
2005
Drosophila sp. (in: flies)
Bhat, J.Y.; Shastri, B.G.; Balaram, H.
Kinetic and biochemical characterization of Plasmodium falciparum guanosine 5-monophosphate synthetase
Biochem. J.
409
263-273
2007
Plasmodium falciparum
Abbott, J.L.; Newell, J.M.; Lightcap, C.M.; Olanich, M.E.; Loughlin, D.T.; Weller, M.A.; Lam, G.; Pollack, S.; Patton, W.A.
The effects of removing the GAT domain from E. coli GMP synthetase
Protein J.
25
483-491
2006
Escherichia coli (P04079), Escherichia coli
Jiang, L.; Zhao, J.; Guo, R.; Li, J.; Yu, L.; Xu, D.
Functional characterization and virulence study of ADE8 and GUA1 genes involved in the de novo purine biosynthesis in Candida albicans
FEMS Yeast Res.
10
199-208
2010
Candida albicans, Candida albicans CAI-4
Jewett, M.W.; Lawrence, K.A.; Bestor, A.; Byram, R.; Gherardini, F.; Rosa, P.A.
GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
J. Bacteriol.
191
6231-6241
2009
Borreliella burgdorferi
Maruoka, S.; Horita, S.; Lee, W.C.; Nagata, K.; Tanokura, M.
Crystal structure of the ATPPase subunit and its substrate-dependent association with the GATase subunit: a novel regulatory mechanism for a two-subunit-type GMP synthetase from Pyrococcus horikoshii OT3
J. Mol. Biol.
395
417-429
2010
Pyrococcus horikoshii (O59071), Pyrococcus horikoshii (O59072), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O59071), Pyrococcus horikoshii OT-3 (O59072)
van der Knaap, J.A.; Kozhevnikova, E.; Langenberg, K.; Moshkin, Y.M.; Verrijzer, C.P.
Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes
Mol. Cell. Biol.
30
736-744
2010
Drosophila melanogaster
Bhat, J.Y.; Venkatachala, R.; Singh, K.; Gupta, K.; Sarma, S.P.; Balaram, H.
Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays
Biochemistry
50
3346-3356
2011
Plasmodium falciparum
Iglesias-Gato, D.; Martin-Marcos, P.; Santos, M.A.; Hinnebusch, A.G.; Tamame, M.
Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae
Genetics
187
105-122
2011
Saccharomyces cerevisiae
Chatterjee, S., Killiny, N., Almeida, R.P., Lindow, S.E.
Role of cyclic di-GMP in Xylella fastidiosa biofilm formation, plant virulence, and insect transmission
Mol. Plant Microbe Interact.
23
1356-63
2010
Xylella fastidiosa
Maruoka, S.; Lee, W.C.; Kamo, M.; Kudo, N.; Nagata, K.; Tanokura, M.
Crystal structure of glutamine amidotransferase from Pyrococcus horikoshii OT3
Proc. Jpn. Acad. Ser. B
81
459-462
2005
Pyrococcus horikoshii (O59071), Pyrococcus horikoshii OT-3 (O59071)
-
Franco, T.M.; Rostirolla, D.C.; Ducati, R.G.; Lorenzini, D.M.; Basso, L.A.; Santos, D.S.
Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain
Arch. Biochem. Biophys.
517
1-11
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Oliver, J.C.; Linger, R.S.; Chittur, S.V.; Davisson, V.J.
Substrate activation and conformational dynamics of guanosine 5'-monophosphate synthetase
Biochemistry
52
5225-5235
2013
Escherichia coli
Ali, R.; Kumar, S.; Balaram, H.; Sarma, S.P.
1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii
Biomol. NMR Assign.
6
193-196
2012
Methanocaldococcus jannaschii
Bhat, J.Y.; Venkatachala, R.; Balaram, H.
Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase
FEBS J.
278
3756-3768
2011
Plasmodium falciparum
Welin, M.; Lehtiö, L.; Johansson, A.; Flodin, S.; Nyman, T.; Trésaugues, L.; Hammarström, M.; Gräslund, S.; Nordlund, P.
Substrate specificity and oligomerization of human GMP synthetase
J. Mol. Biol.
425
4323-4333
2013
Homo sapiens (P49915), Homo sapiens
html completed
