EC Number   |
General Information |
Reference |
|---|
    6.3.5.2 | malfunction |
cgsA mutants exhibit a hyperadhesive phenotype in vitro and overexpress gumJ, hxfA, hxfB, xadA, and fimA, which promote attachment of cells to surfaces and biofilm formation. The mutants are greatly reduced in virulence to grape albeit still transmissible by insect vectors, although at a reduced level compared with transmission rates of the wild-type strain, despite the fact that similar numbers of cells of the cgsA mutant are acquired by the insects from infected plants. High levels of EPS are measured in cgsA mutants compared with wild-type strains. Scanning electron microscopy analysis reveal a thicker amorphous layer surrounding the mutants. Overexpression of cgsA in a cgsA-complement mutant conferred the opposite phenotypes in vitro |
716282 |
| 6.3.5.2 | malfunction |
GMPS/USP7 complex mutants display severe misregulation of ecdysone target genes |
705708 |
| 6.3.5.2 | metabolism |
GMPS catalyzes the final step of the de novo synthetic pathway of purine nucleotides |
-, 705173 |
| 6.3.5.2 | metabolism |
key enzyme in the purine salvage pathways |
704308 |
| 6.3.5.2 | physiological function |
GMP synthetase binds ubiquitin-specific protease USP7 and is required for its ability to deubiquitylate histone H2B. Strong cooperation between GMPS and USP7, which is counteracted by the histone H2B ubiquitin ligase BRE1. Loss of either GMPS or USP7 leads to increased levels of histone H2Bub in mutant animals. GMPS/USP7 binds ecdysone-regulated loci and mutants display severe misregulation of ecdysone target genes. Ecdysone receptor EcR interacts biochemically and genetically with GMPS/USP7. Analyses suggest that GMPS/USP7 acts as a transcriptional corepressor |
705708 |
| 6.3.5.2 | physiological function |
GMPS is required for its ability to deubiquitylate histone H2B. A key enzyme in the guanine nucleotide biosynthesis pathway is involved in nuclear receptor target silencing suggests that GMPS might provide a relay between metabolic state and developmental gene switching |
705708 |
| 6.3.5.2 | physiological function |
the enzymatic activities encoded by the guaAB operon are essential for Borrelia burgdorferi mouse infectivity and provide a growth advantage to spirochetes in the tick, GuaA protein is expressed during infection of mammalian hosts and is critical for the survival of Borrelia burgdorferi in the infection cycle, overview |
704308 |
